南非加强性传播感染/艾滋病毒合作伙伴通知-猫眼课题宝

南非加强性传播感染/艾滋病毒合作伙伴通知

批准号：

9223573

负责人：

SETH C KALICHMAN

金额：

$56.31万

依托单位：

UNIVERSITY OF CONNECTICUT STORRS

依托单位国家：

美国

项目类别：

财政年份：

2013

资助国家：

美国

项目状态：

已结题

起止时间：

2013-04-01 至 2019-01-31

来源：

https://reporter.nih.gov/project-details/9223573

关键词：

AIDS prevention AIDS/HIV problem Acquired Immunodeficiency Syndrome Affect Africa South of the Sahara Age Area Attention Behavioral Blood Circulation CD4 Positive T Lymphocytes Cells Central City Cessation of life Clinic Clinic Visits Communication Contracts Counseling Diagnosis Diagnostic Education Epidemic Event Exercise Exposure to HIV HIV Infections HIV Seropositivity HIV risk Health Health behavior change Helper-Inducer T-Lymphocyte Home environment Immune Infection Infection prevention Intervention Intervention Trial Investigation Laboratories Measures Mediating Mediation Modeling Motivation Notification Outcome Participant Partner Communications Partner Notification Patients Population Prevalence Preventive Intervention Provider Randomized Randomized Clinical Trials Recruitment Activity Research Research Design Resources Risk Risk Reduction Services Sexual Partners Sexually Transmitted Diseases South Africa South African Southern Africa Testing Time Ulcer Woman arm base co-infection communication behavior condoms evidence base follow-up high risk high risk population improved indexing innovation intervention effect macrophage men post intervention prevent primary outcome protective behavior public health relevance randomized trial secondary outcome sex risk sexual HIV transmission skills skills training social cognitive theory theories

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DESCRIPTION (provided by applicant): This 5-year study will conduct a randomized clinical trial of a culturally tailored theory-based behavioral risk reduction and enhanced partner notification intervention for men and women who are receiving sexually transmitted infection (STI) diagnostic and treatment services in South Africa. Among the world's most severe HIV epidemics, as many as one in five South Africans living in the most affected areas are HIV positive. The experimental intervention in this study is grounded in social-cognitive theories of health behavior change and has been pre-tested in preliminary research. The intervention consists of a single 60-minute risk reduction counseling session with behavioral skills building components to enhance partner communication skills for improved partner notification. The study design includes two comparison conditions: behavioral risk reduction counseling without partner communication and notification skills enhancement, and a standard didactic health information condition. We will recruit 525 men and 525 women from a large STI clinic in Cape Town. Participants will be STI clinic patients age 18 or older who are receiving STI services. Participants will be baseline assessed and randomized to receive either (a) the 60-minute theory-based and culturally tailored risk reduction and partner communication/notification intervention; (b) a 60-minute risk reduction counseling intervention without partner communication/notification components; or (c) a time and contact matched 60-minute standard didactic health information session. Participants will be followed for 12 months post intervention. The study will test intervention effects on two primary endpoints: contracting new STI and objectively measured partner notification events. The randomized trial will determine the efficacy of the risk reduction intervention for South African men and women receiving STI clinic services. We will also test the mediating effects of partner notification on STI outcomes. Results of this research will therefore test a clinic-based HIV prevention intervention model that is urgently needed in South Africa.

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