Core 1 - Acquisition

磁共振(MR)成像(MRI)和光谱(MRS)是最强大的 研究大脑结构、功能和神经化学的工具。它们的丰富性和准确性 结构、功能和神经化学信息与数据质量密切相关，因此数据质量很高 和超高系统提供了主要的优势，特别是优越的信噪比(SNR)，空间和 光谱分辨率。此核心的目标是加速、扩展和增强大量 雄心勃勃的神经科学研究，提供必要的支持和基础设施，使大型 NINDS社区资助的调查人员受益于先进的MRI和MRS方法和 研究大脑结构和功能的仪器。因此，该核心将扩展访问 神经科学家对CMRR提供的超高场和超高场磁共振资源的支持，包括 7个运行在3T(X3)、4T、7T(X2)和10.5T的人类MR系统，以及两个动物MR系统 在9.4T和16.4T下运行。我们提出以下具体目标：目标1：提供技术支持 在获取MRI和多核MRS数据以支持脑研究方面的专业知识和协助 活体中的人和动物。目标2：提供专门的MRI和MRS编程方面的专业知识 脉冲序列，并在优化序列和采集协议参数方面进行实验 NINDS机构中心核心支持的项目对人类(3T、4T、7T、 10.5T)和动物(9.4T、16.4T)系统安装在使用瓦里安或西门子平台的仪器上。 目标3：制造、维护和定制高性能多通道射频线圈，供人类和 动物研究，与刺激呈现、监测设备或其他必要的实验相兼容 设备，以便能够在所有系统上进行大规模磁共振数据采集，同时执行射频线圈 并对扫描仪质量进行控制，确保受检者安全。

Magnetic Resonance (MR) Imaging (MRI) and Spectroscopy (MRS) are among the most powerful tools to investigate brain structure, function and neurochemistry. The richness and accuracy of these structural, functional and neurochemical information are critically linked to data quality, for which high and ultra-high systems offer major advantages, notably superior signal-to-noise ratio (SNR), spatial and spectral resolution. The goal of this Core is to accelerate, broaden and enhance a large array of ambitious neuroscience research, providing necessary support and infrastructure to allow a large community of NINDS funded investigators to benefit from advanced MRI and MRS methodologies and instrumentation to study brain structure and function. This Core will thus expand the access for neuroscientists, to the exceptional high and ultrahigh field MR resources available at CMRR, including seven human MR systems operating at 3T (x3), 4T, 7T (x2) and 10.5T, and two animals MR systems operating at 9.4T and 16.4T. We propose the following specific aims: Aim 1: To provide technical expertise and assistance in acquiring MRI and multinuclear MRS data to support brain research in humans and animals in vivo. Aim 2: To provide expertise in programming specialized MRI and MRS pulse sequences, and in optimizing sequence and acquisition protocol parameters for experimental needs of projects supported by the NINDS Institutional Center Cores for both human (3T, 4T, 7T, 10.5T) and animal (9.4T, 16.4T) systems on instruments operated with Varian or Siemens platforms. Aim 3: To build, maintain and customize high performance multi-channel RF coils for human and animal studies, compatible with stimulus presentation, monitoring device or other required experimental equipment, in order to enable large scale MR data acquisition on all systems, while performing RF coil and scanner quality control and ensuring subject safety.