Core 1 - Acquisition

核心 1 - 获取

• 批准号: 9432738
• 负责人: Pierre-Francois VAN DE MOORTELE
• 金额: $ 19.87万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9432738
• 关键词: Animals; Biochemical; Brain; Brain Diseases; Communities; Custom; Data; Data Quality; Detection; Diffusion; Disease Progression; Doctor of Philosophy; Effectiveness; Ensure; Equipment; Fiber; Funding; Goals; Human; Link; Magnetic Resonance; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Methodology; Methods; Modality; Monitor; National Institute of Neurological Disorders and Stroke; Neuraxis; Neurosciences Research; Noise; Operating System; Performance; Physiologic pulse; Protocols documentation; Quality Control; RF coil; Reproducibility; Research; Research Infrastructure; Research Personnel; Resolution; Resources; Rest; Safety; Signal Transduction; Spectrum Analysis; Stimulus; Structure; Surrogate Markers; System; Technical Expertise; United States National Institutes of Health; base; brain research; connectome; data acquisition; improved; in vivo; instrument; instrumentation; magnetic field; monitoring device; multidisciplinary; neurochemistry; neuroimaging; novel therapeutics; spectroscopic imaging; tool; translational neuroscience; virtual

Magnetic Resonance (MR) Imaging (MRI) and Spectroscopy (MRS) are among the most powerful tools to investigate brain structure, function and neurochemistry. The richness and accuracy of these structural, functional and neurochemical information are critically linked to data quality, for which high and ultra-high systems offer major advantages, notably superior signal-to-noise ratio (SNR), spatial and spectral resolution. The goal of this Core is to accelerate, broaden and enhance a large array of ambitious neuroscience research, providing necessary support and infrastructure to allow a large community of NINDS funded investigators to benefit from advanced MRI and MRS methodologies and instrumentation to study brain structure and function. This Core will thus expand the access for neuroscientists, to the exceptional high and ultrahigh field MR resources available at CMRR, including seven human MR systems operating at 3T (x3), 4T, 7T (x2) and 10.5T, and two animals MR systems operating at 9.4T and 16.4T. We propose the following specific aims: Aim 1: To provide technical expertise and assistance in acquiring MRI and multinuclear MRS data to support brain research in humans and animals in vivo. Aim 2: To provide expertise in programming specialized MRI and MRS pulse sequences, and in optimizing sequence and acquisition protocol parameters for experimental needs of projects supported by the NINDS Institutional Center Cores for both human (3T, 4T, 7T, 10.5T) and animal (9.4T, 16.4T) systems on instruments operated with Varian or Siemens platforms. Aim 3: To build, maintain and customize high performance multi-channel RF coils for human and animal studies, compatible with stimulus presentation, monitoring device or other required experimental equipment, in order to enable large scale MR data acquisition on all systems, while performing RF coil and scanner quality control and ensuring subject safety.

磁共振（MR）成像（MRI）和波谱（MRS）是最强大的 研究大脑结构、功能和神经化学的工具。这些信息的丰富性和准确性 结构、功能和神经化学信息与数据质量密切相关， 和超高系统提供了主要的优势，特别是优越的上级信噪比（SNR），空间和 光谱分辨率该核心的目标是加速、扩大和加强一系列 雄心勃勃的神经科学研究，提供必要的支持和基础设施，使一个大的 NINDS社区资助的研究人员受益于先进的MRI和MRS方法， 研究大脑结构和功能的仪器。因此，该核心将扩大 神经科学家，到CMRR提供的特殊高场和高场强MR资源，包括 在3T（x3）、4T、7T（x2）和10.5T下运行的7台人体MR系统和2台动物MR系统 在9.4T和16.4T下运行。我们提出了以下具体目标：目标1：提供技术援助， 专业知识和协助获取MRI和多核MRS数据，以支持大脑研究， 人体和动物体内。目标2：提供专业MRI和MRS编程的专业知识 脉冲序列，并在优化序列和采集协议参数的实验 NINDS机构中心核心支持的项目的需求，包括人类（3T，4T，7T， 10.5T）和动物（9.4T，16.4T）系统。 目标3：构建、维护和定制高性能多通道射频线圈， 动物研究，与刺激呈现、监测装置或其他所需实验兼容 设备，以便在所有系统上实现大规模MR数据采集，同时执行RF线圈 扫描仪质量控制和确保受试者安全。