Life Course Investigation of People Who Inject Drugs

注射吸毒者生命历程调查

• 批准号: 9031757
• 负责人: ROBERT Edwin BOOTH
• 金额: $ 55.9万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-04-01 至 2020-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9031757
• 关键词: AIDS prevention; AIDS/HIV problem; Abstinence; Accounting; Acquired Immunodeficiency Syndrome; Address; Affect; African American; Age; Alcohol or Other Drugs use; Behavior; Birth; Centers for Disease Control and Prevention (U.S.); Child; Childbirth; Cities; Colorado; Communities; Data; Drug usage; Drug user; Environment and Public Health; Epidemic; Epidemiologic Studies; Ethnic Origin; Event; Female; Frequencies; Gender; Goals; HIV; HIV Infections; HIV risk; HIV/HCV; Health; Hepatitis C virus; Hispanics; Imprisonment; Injecting drug user; Injection of therapeutic agent; Intervention; Investigation; Life; Life Cycle Stages; Light; Literature; Mediating; Monitor; Morbidity - disease rate; National Institute of Drug Abuse; Natural History; Needle Sharing; Not Hispanic or Latino; Opiates; Outcome; Overdose; Participant; Pattern; Personality Disorders; Pharmaceutical Preparations; Play; Policies; Population; Prevention; Randomized Controlled Trials; Recruitment Activity; Relapse; Reporting; Research; Research Project Grants; Risk; Risk Behaviors; Risk Reduction; Role; Site; Time; U-Series Cooperative Agreements; United States; United States National Institutes of Health; Vulnerable Populations; Woman; Work; anti social; base; cohort; design; grandchild; high risk; injection drug use; male; marijuana legalization; marijuana use; men; methadone maintenance; mortality; outreach; pandemic disease; prescription opiate; public health relevance; sex risk; trend

 DESCRIPTION (provided by applicant) For the past 19 years, we have conducted large randomized controlled trials with out-of- treatment people who inject drugs (PWID) in Denver. This research has been focused on facilitating substance use treatment entry and retention as a means of reducing HIV risk behaviors and drug use. While this work has added substantially to our knowledge of risk behaviors and risk reduction strategies in the short term, major questions remain unanswered regarding the life course of these behaviors. In this proposal, we will assess long term changes in HIV risk behaviors and drug use among PWID with a goal of describing and evaluating the natural history of PWID and identifying important predictors of life course behaviors of PWID. It is hypothesized that HIV risk behaviors, opiate use and mortality will be affected by major life events, such as overdose, incarceration, and policy changes. Also, patterns of HIV risk behavior and drug use maybe affected by other factors such as gender, ethnicity and age. This study will contribute to the literature on prevention of HIV risk behavior and reduction in morbidity and mortality over the life course in this highly vulnerable population of PWID.

 描述（由申请人提供）在过去的19年里，我们在丹佛对注射毒品（PWID）的治疗外人群进行了大型随机对照试验。这项研究的重点是促进物质使用治疗的进入和保留，作为减少艾滋病毒风险行为和药物使用的一种手段。虽然这项工作在短期内大大增加了我们对风险行为和风险降低策略的了解，但关于这些行为的生命过程的主要问题仍然没有答案。在这项提案中，我们将评估艾滋病毒的危险行为和药物使用的长期变化之间的PWID与描述和评估PWID的自然历史和确定重要的预测PWID的生命过程中的行为的目标。据推测，艾滋病毒的危险行为，阿片类药物的使用和死亡率将受到重大生活事件，如过量，监禁和政策变化的影响。此外，艾滋病毒危险行为和药物使用的模式可能受到其他因素的影响，如性别，种族和年龄。这项研究将有助于预防艾滋病毒的危险行为和减少发病率和死亡率在这个高度脆弱的人群PWID的生命过程中的文献。