Life Course Investigation of People Who Inject Drugs

 描述（由申请人提供） 在过去 19 年中，我们在丹佛对未接受治疗的注射吸毒者 (PWID) 进行了大型随机对照试验。这项研究的重点是促进物质使用治疗的进入和保留，作为减少艾滋病毒危险行为和药物使用的一种手段。虽然这项工作在短期内大大增加了我们对风险行为和风险降低策略的了解，但有关这些行为的生命周期的主要问题仍未得到解答。在本提案中，我们将评估注射吸毒者中艾滋病毒危险行为和药物使用的长期变化，目的是描述和评估注射吸毒者的自然史，并确定注射吸毒者生命历程行为的重要预测因素。据推测，艾滋病毒危险行为、阿片类药物使用和死亡率将受到重大生活事件的影响，例如吸毒过量、监禁和政策变化。此外，艾滋病毒危险行为和吸毒模式可能受到性别、种族和年龄等其他因素的影响。这项研究将为有关预防艾滋病毒危险行为以及降低这一高度脆弱的吸毒者生命周期中的发病率和死亡率的文献做出贡献。

 DESCRIPTION (provided by applicant) For the past 19 years, we have conducted large randomized controlled trials with out-of- treatment people who inject drugs (PWID) in Denver. This research has been focused on facilitating substance use treatment entry and retention as a means of reducing HIV risk behaviors and drug use. While this work has added substantially to our knowledge of risk behaviors and risk reduction strategies in the short term, major questions remain unanswered regarding the life course of these behaviors. In this proposal, we will assess long term changes in HIV risk behaviors and drug use among PWID with a goal of describing and evaluating the natural history of PWID and identifying important predictors of life course behaviors of PWID. It is hypothesized that HIV risk behaviors, opiate use and mortality will be affected by major life events, such as overdose, incarceration, and policy changes. Also, patterns of HIV risk behavior and drug use maybe affected by other factors such as gender, ethnicity and age. This study will contribute to the literature on prevention of HIV risk behavior and reduction in morbidity and mortality over the life course in this highly vulnerable population of PWID.