Negative Pressure Wound Therapy to Soft Tissues Surrounding Percutaneous Devices
经皮装置周围软组织的负压伤口治疗
基本信息
- 批准号:9248815
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2015
- 资助国家:美国
- 起止时间:2015-05-01 至 2019-04-30
- 项目状态:已结题
- 来源:
- 关键词:AmputeesAnimal ModelAnimalsBiochemicalBiologicalCaviaClinicalComplexCuesDeteriorationDevelopmentDevicesDockingEpithelialEtiologyEuropeEuropeanEvaluationExhibitsFDA approvedFosteringGoalsGrowthHealthcare SystemsHeterotopic OssificationHistologicHuman VolunteersImplantInfectionLeadMaintenanceMilitary PersonnelModelingOperative Surgical ProceduresPatientsPopulationPostoperative PeriodProcessProsthesisPseudomonas aeruginosaQuality of lifeRecovery of FunctionResidual stateSiteStaphylococcus aureusSuspensionsSystemSystemic infectionTechniquesTechnologyTestingTimeTissuesTitaniumUnited StatesVacuumWeight-Bearing stateWorkWound Healingbonechronic woundclinical applicationclinically relevantcookingdesignexperiencehealingimplantationimprovedlimb amputationlimb injurymicrobialpressurepreventpublic health relevanceresidual limbresponsesealsoft tissuestandard of caresubcutaneousworking groupwound
项目摘要
DESCRIPTION (provided by applicant):
Following limb amputation, suspension-type attachment of an exoprosthesis to the residual limb is currently the standard of care, but is not suitable for every patient. For example, suspension technology fails with patients with short residual limbs, whom experience persistent deterioration of soft tissues, and/or hampered by exuberant heterotopic ossification. It is for these patients that Percutaneous Osseointegrated Docking Systems (PODS) are being developed worldwide so they can attach their exoprosthesis directly to the bone of their residual limb. In Europe, thre primary groups are working with human volunteer amputees to investigate PODS technology. However, these European PODS are not currently FDA approved for use in the United States, in part, because they lack evidence of an infection-free biological seal between the periprosthetic tissues and the PODS device. Here in the United States, our team has worked since 2006 on the design, the development, and the evaluation of a new type of PODS device. We have shown that endoprosthetic PODS devices, incorporating porous-coated titanium subdermal barriers, have the ability to inhibit infection by maintaining a biologically attached epithelial seal in load-bearing animals for at least 12- months. However, within the first 12-weeks post-implantation, the periprosthetic tissues surrounding the PODS device << exhibit a chronic wound healing response and >> migrate along the percutaneous interface, possibly in an attempt to make the device extra-cutaneous, a process known as down growth. This is of concern because << down growth breaks the biologically attached epithelial seal, creating a gap >> between the periprosthetic tissues and the PODS device, a direct conduit for microbial invasion - one that can lead to local, or even systemic infection. << To maximize the functional recovery of patients with amputated limbs, we >> need to establish, to maintain, and if necessary, to re-establish a non-migratory biological seal between the periprosthetic tissues and the PODS device. Clinically, chronic wounds are often closed using a technique known as Vacuum Assisted Closure (VAC) therapy, << also known as Negative Pressure Wound Therapy (NPWT) >>. We will first determine if << NPWT can inhibit the down growth >> and subsequent infection of the periprosthetic tissues surrounding PODS devices. Second, we will establish whether << NPWT >> is required to maintain the biological seal over time. Third, in the << presence of a gap between the periprosthetic tissues and the PODS device >>, we will determine whether NPWT can re-establish the biological seal between the periprosthetic tissues and the PODS device. The results from this study will facilitate the safe clinical introduction of percutaneous osseointegrated prostheses, improving the quality of life for patients in the VA, military, and broader civilian populations with severe limb injuries.
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Kent N. Bachus其他文献
Biomechanical Comparison of Acromioclavicular Joint Reconstructions Using Coracoclavicular Tendon Grafts With and Without Coracoacromial Ligament Transfer
- DOI:
10.1016/j.arthro.2010.05.023 - 发表时间:
2011-01-01 - 期刊:
- 影响因子:
- 作者:
Todd Clevenger;Richard E. Vance;Kent N. Bachus;Robert T. Burks;Robert Z. Tashjian - 通讯作者:
Robert Z. Tashjian
Comparison of <em>in vitro</em> techniques to controllably decrease bone mineral density of cancellous bone for biomechanical compressive testing
- DOI:
10.1016/j.medengphy.2014.02.003 - 发表时间:
2014-06-01 - 期刊:
- 影响因子:
- 作者:
Francesca R. Nichols;Kent N. Bachus - 通讯作者:
Kent N. Bachus
Kent N. Bachus的其他文献
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{{ truncateString('Kent N. Bachus', 18)}}的其他基金
Functional Expectations of Transhumeral Percutaneous Osseointegration Patients.
经肱骨经皮骨整合患者的功能预期。
- 批准号:
9929447 - 财政年份:2018
- 资助金额:
-- - 项目类别:
Functional Expectations of Transhumeral Percutaneous Osseointegration Patients.
经肱骨经皮骨整合患者的功能预期。
- 批准号:
10475095 - 财政年份:2018
- 资助金额:
-- - 项目类别:
Functional Expectations of Transhumeral Percutaneous Osseointegration Patients.
经肱骨经皮骨整合患者的功能预期。
- 批准号:
10833462 - 财政年份:2018
- 资助金额:
-- - 项目类别:
Functional Expectations of Transhumeral Percutaneous Osseointegration Patients.
经肱骨经皮骨整合患者的功能预期。
- 批准号:
10261447 - 财政年份:2018
- 资助金额:
-- - 项目类别:
Negative Pressure Wound Therapy to Soft Tissues Surrounding Percutaneous Devices
经皮装置周围软组织的负压伤口治疗
- 批准号:
8866571 - 财政年份:2015
- 资助金额:
-- - 项目类别:
Negative Pressure Wound Therapy to Soft Tissues Surrounding Percutaneous Devices
经皮装置周围软组织的负压伤口治疗
- 批准号:
9046399 - 财政年份:2015
- 资助金额:
-- - 项目类别:
Percutaneous Osseointegrated Docking System for Above Elbow Amputees
用于肘部以上截肢者的经皮骨整合对接系统
- 批准号:
8782802 - 财政年份:2014
- 资助金额:
-- - 项目类别:
Percutaneous Osseointegrated Docking System for Above Elbow Amputees
用于肘部以上截肢者的经皮骨整合对接系统
- 批准号:
9188778 - 财政年份:2014
- 资助金额:
-- - 项目类别:
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