Hybrid organometallic_carbon nanotube films for enhanced chemiresistive sensors

用于增强化学电阻传感器的混合有机金属碳纳米管薄膜

• 批准号: 9207768
• 负责人: Sibo Lin
• 金额: $ 5.71万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-02-04 至 2018-02-03
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9207768
• 关键词: Acetone; Acetonitriles; Address; Advanced Development; Air; Asthma; Biochemistry; Biological Markers; Calibration; Canis familiaris; Carbon Dioxide; Carbon Monoxide; Carbon Nanotubes; Cells; Chemicals; Complex Mixtures; Consumption; Deposition; Detection; Development; Devices; Diagnosis; Diagnostic; Disease; Electrodes; Electronic Mail; Ethanol; Ethylenes; Evolution; Exhalation; Exhibits; Exposure to; Face; Film; Fingerprint; Formaldehyde; Gas Chromatography; Gases; Goals; Gold; Health; Healthcare; Heart failure; Human body; Hybrids; Hydrogen; Individual; Indoor pollutant; Lead; Ligands; Location; Malignant neoplasm of lung; Mass Fragmentography; Measurement; Measures; Medical; Metals; Methane; Methanol; Monitor; Nanotubes; Nitrogen; Nose; Oxidation-Reduction; Oxygen; Patients; Persons; Research; Rest; Sampling; Smell Perception; Stream; Synthesis Chemistry; Techniques; Technology; Testing; Thinness; Time; Toxic effect; Training; Water; Work; absorption; accurate diagnosis; base; chemical fingerprinting; cost; cost effective; design; disease diagnosis; infrared spectroscopy; instrumentation; nanoparticle; next generation; portability; prevent; public health relevance; response; screening; sensor; single walled carbon nanotube; vapor; volatile organic compound

 DESCRIPTION (provided by applicant): This proposal describes the development of portable, cost-effective, and energy-efficient chemical sensors for detection of carbon monoxide, formaldehyde, methanol, ethanol, acetone, and hydrogen. Sensing these volatile compounds could both prevent and diagnose health problems. Some diseases are attributed to exposure to low levels of a volatile compound. For instance, formaldehyde, a common indoor pollutant, has been correlated with asthma rates. On the other hand, the human body exhales a set of molecules containing diagnostic information on the health of the individual. For example, trained dogs can detect lung cancer by the smell of a person's breath. Cost-effective and low-powered gas sensors could be deployed in an always-on networked array to prevent exposure to harmful chemicals; portability could extend application of gas sensors to monitoring personal health, which could revolutionize breath vapor analysis in health care. Current sensor technologies are limited. While gas chromatography is the gold standard for accurately identifying trace compounds, the instrumentation is costly and requires specialized training to operate. Other platforms to detect volatiles (fuel cells, infrared spectroscopy, etc.) may be simpler to operate, but face problems with sensitivity, selectivity, cost, and power consumption. To tackle these issues, an "electronic nose" strategy has been explored in which an array of sensors is utilized in concert to determine the chemical fingerprint of a vapor sample. In particular, Swager and coworkers have investigated resistive sensors based on functionalized carbon nanotube networks, potentially leading to inexpensive, low-powered, robust, and portable chemical sensors. Further improvements in sensitivity and selectivity of these sensors could lead to commercially viable devices. The goal of this research is to make a network of single-walled carbon nanotubes connected by organometallic linkages. These linkages are designed to increase electronic communication between adjacent nanotubes and, thus, the overall resting conductivity. Select volatile compounds are expected to disrupt these organometallic centers via oxidation, reduction, or ligand substitution. The overall sensor should be more sensitive and selective than purely organic-functionalized or metal-functionalized nanotube networks. The ultimate goal of this work is to develop sensitive, portable, and always-on sensors to detect environmental VOC exposure at levels well below toxicity thresholds and to monitor breath vapor VOCs of patients to aid in diagnosis of diseases such as lung cancer.

 描述(由申请人提供)：本提案描述了用于检测一氧化碳、甲醛、甲醇、乙醇、丙酮和氢气的便携式、低成本、高能效的化学传感器的开发。感知这些挥发性化合物可以预防和诊断健康问题。一些疾病被归因于接触低水平的挥发性化合物。例如，甲醛是一种常见的室内污染物，它与哮喘发病率有关。另一方面，人体呼出一组分子，其中包含有关个体健康的诊断信息。例如，经过训练的狗可以通过人的呼吸的气味来检测肺癌。高性价比和低功耗的气体传感器可以部署在始终在线的网络阵列中，以防止暴露在有害化学物质中；便携性可以将气体传感器的应用扩展到监测个人健康，这可能会彻底改变医疗保健中的呼气分析。目前的传感器技术是有限的。虽然气相色谱是准确识别痕量化合物的黄金标准，但仪器设备成本高昂，需要专门的培训才能操作。其他检测挥发物的平台(燃料电池、红外光谱等)操作可能更简单，但面临灵敏度、选择性、成本和功耗方面的问题。为了解决这些问题，人们探索了一种“电子鼻”战略，在这种战略中，一系列传感器被联合使用来确定蒸气样本的化学指纹。特别是，Swager和他的同事研究了基于功能化碳纳米管网络的电阻传感器，可能会导致廉价、低功率、坚固和便携式的化学传感器。这些传感器在灵敏度和选择性方面的进一步改进可能会导致商业上可行的设备。 这项研究的目标是通过有机金属键连接的单壁碳纳米管网络。这些连接旨在增加相邻纳米管之间的电子通信，从而提高整体静止导电性。某些挥发性化合物有望通过氧化、还原或配体取代来破坏这些有机金属中心。整个传感器应该比纯有机功能化或金属功能化的纳米管网络更灵敏和选择性更高。这项工作的最终目标是开发灵敏、便携和始终开启的传感器，以检测远低于毒性阈值的环境VOC暴露水平，并监测患者的呼气VOCs，以帮助诊断肺癌等疾病。