Generating Synergy Between Protein and Non-Protein Macromolecular Adjuvants

蛋白质和非蛋白质大分子佐剂之间产生协同作用

• 批准号: 9574346
• 负责人: SHUANG CAI
• 金额: $ 22.5万
• 依托单位: HAFION, LLC
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-01 至 2018-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9574346
• 关键词: Adjuvant; Bordetella pertussis; Contractor; Enterotoxins; Escherichia coli; Hyaluronan; Immunologics; Molecular Weight; Pertussis; Proteins; synergism

The Contractor will examine the additive and potentially synergistic activities of two potential adjuvants as a combined adjuvant: low molecular weight hyaluronan (Haf) and the A1 subunit of the Escherichia coli heat-labile enterotoxin (LTA). The adjuvants will be examined in the context of protection against Bordetella pertussis, the causative agent of pertussis (whooping cough).

承包商将检查两种潜在佐剂作为组合佐剂的相加和潜在协同活性：低分子量透明质酸（Haf）和大肠杆菌不耐热肠毒素（LTA）的A1亚单位。 将在针对百日咳（百日咳）的病原体百日咳博德特氏菌的保护作用的背景下检查佐剂。