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Large Scale T Cell Epitope Discovery: Genome-wide characterization of T cell epitopes from Bordetella pertussis in vaccination and natural infection

Large Scale T Cell Epitope Discovery: Genome-wide characterization of T cell epitopes from Bordetella pertussis in vaccination and natural infection
大规模 T 细胞表位发现:疫苗接种和自然感染中百日咳博德特氏菌 T 细胞表位的全基因组特征
批准号:
10616655
负责人:
Alessandro Sette
金额:
$87.95万
依托单位国家:
美国
项目类别:
财政年份:
2019
资助国家:
美国
项目状态:
已结题
起止时间:
2019-09-30 至 2023-09-29

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中文摘要
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英文摘要
This contract supports highly interactive, multi-disciplinary teams, whose research efforts are focused on large-scale discovery of T cell immune epitopes, validation of these epitopes, and defining their role in immune protection or immune-mediated pathogenesis in humans. Milestones include: 1) epitope identification; 2) in vitro epitope validation studies with primary human T cells to demonstrate the immunogenicity/antigenicity or diagnostic potential of all newly defined T cell epitopes shown to bind to classical or non-classical MHC molecules; and 3) submission of all epitope information and computer software to the Immune Epitope Database and Analysis Resource to facilitate access and use of the data and tools by the broader research community.
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Human immune signatures of Dengue virus and Mycobacterium Tuberculosis exposure in infection, disease and vaccination
  • 批准号:
    10265651
  • 项目类别:
  • 资助金额:
    $29.28万
  • 财政年份:
    2020
  • 负责人:
    Alessandro Sette
  • 依托单位:
Human immune signatures of Dengue virus and Mycobacterium Tuberculosis exposure in infection, disease and vaccination
  • 批准号:
    10228367
  • 项目类别:
  • 资助金额:
    $29.28万
  • 财政年份:
    2020
  • 负责人:
    Alessandro Sette
  • 依托单位:
Human immune signatures of Dengue virus and Mycobacterium Tuberculosis exposure in infection, disease and vaccination
  • 批准号:
    10056696
  • 项目类别:
  • 资助金额:
    $272.15万
  • 财政年份:
    2020
  • 负责人:
    Alessandro Sette
  • 依托单位:
国内基金
海外基金
Neo-antigens暴露对肾移植术后体液性排斥反应的影响及其机制研究
  • 批准号:
    2022J011295
  • 项目类别:
    省市级项目
  • 资助金额:
    10.0万元
  • 批准年份:
    2022
  • 负责人:
    王亚伟
  • 依托单位:
结核分枝杆菌持续感染期抗原(latency antigens)的重组BCG疫苗研究