Large Scale T Cell Epitope Discovery: Genome-wide characterization of T cell epitopes from Bordetella pertussis in vaccination and natural infection
Large Scale T Cell Epitope Discovery: Genome-wide characterization of T cell epitopes from Bordetella pertussis in vaccination and natural infection
批准号:
10616655
负责人:
Alessandro Sette
金额:
$87.95万
依托单位国家:
美国
项目类别:
财政年份:
2019
资助国家:
美国
项目状态:
已结题
起止时间:
2019-09-30 至 2023-09-29
关键词:
AllelesAntigensBindingBordetella pertussisCellsCommunitiesComputer softwareDatabasesDiagnosticEpitopesHumanImmuneImmunityIn VitroIncidenceInfectionLinkMediatingPathogenesisPertussisPhenotypePlayResearchResourcesRoleSafetySpecificitySupport ContractsT-LymphocyteT-Lymphocyte EpitopesTestingVaccinationVaccinesValidationdata toolsgenome-wideimmunogenicityimprovedmultidisciplinarynovelvaccine efficacyvalidation studies
中文摘要
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英文摘要
This contract supports highly interactive, multi-disciplinary teams, whose research efforts are focused on large-scale discovery of T cell immune epitopes, validation of these epitopes, and defining their role in immune protection or immune-mediated pathogenesis in humans. Milestones include: 1) epitope identification; 2) in vitro epitope validation studies with primary human T cells to demonstrate the immunogenicity/antigenicity or diagnostic potential of all newly defined T cell epitopes shown to bind to classical or non-classical MHC molecules; and 3) submission of all epitope information and computer software to the Immune Epitope Database and Analysis Resource to facilitate access and use of the data and tools by the broader research community.
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专著(0)
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会议论文
Human immune signatures of Dengue virus and Mycobacterium Tuberculosis exposure in infection, disease and vaccination
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批准号:10265651
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项目类别:
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资助金额:$29.28万
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财政年份:2020
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负责人:Alessandro Sette
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依托单位:
Human immune signatures of Dengue virus and Mycobacterium Tuberculosis exposure in infection, disease and vaccination
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项目类别:
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资助金额:$29.28万
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财政年份:2020
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负责人:Alessandro Sette
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依托单位:
Human immune signatures of Dengue virus and Mycobacterium Tuberculosis exposure in infection, disease and vaccination
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批准号:10056696
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项目类别:
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资助金额:$272.15万
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财政年份:2020
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负责人:Alessandro Sette
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依托单位:
Large Scale T Cell Epitope Discovery: Global identification of epitopes derived from Zika (ZIKV) and Chikungunya (CHIKV) viruses following natural infection and vaccination
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批准号:10020640
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项目类别:
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资助金额:$88.83万
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财政年份:2019
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负责人:Alessandro Sette
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依托单位:
Large Scale T Cell Epitope Discovery: Genome-wide characterization of T cell epitopes from Bordetella pertussis in vaccination and natural infection
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批准号:10439413
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项目类别:
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资助金额:$87.58万
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财政年份:2019
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负责人:Alessandro Sette
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依托单位:
Clinical Studies and LN FNA Core
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批准号:10371991
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项目类别:
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资助金额:$45.24万
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财政年份:2019
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负责人:Alessandro Sette
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依托单位:
Mechanisms of differential responses to whole cell and acellular pertussis vaccination
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批准号:10580758
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项目类别:
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资助金额:$73.15万
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负责人:Alessandro Sette
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依托单位:
Clinical Studies and LN FNA Core
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批准号:10580754
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项目类别:
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资助金额:$16.38万
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负责人:Alessandro Sette
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依托单位:
Mechanisms of differential responses to whole cell and acellular pertussis vaccination
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批准号:10366648
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项目类别:
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资助金额:$15.47万
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负责人:Alessandro Sette
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依托单位:
Mechanisms of differential responses to whole cell and acellular pertussis vaccination
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批准号:10585309
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项目类别:
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资助金额:$80.82万
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财政年份:2019
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负责人:Alessandro Sette
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依托单位:
Large Scale T Cell Epitope Discovery: Genome-wide characterization of T cell epitopes from Bordetella pertussis in vaccination and natural infection
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批准号:10892738
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项目类别:
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资助金额:$88.41万
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依托单位:
Large Scale T Cell Epitope Discovery: Genome-wide characterization of T cell epitopes from Bordetella pertussis in vaccination and natural infection
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项目类别:
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资助金额:$91.88万
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财政年份:2019
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负责人:Alessandro Sette
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依托单位:
Mechanisms of differential responses to whole cell and acellular pertussis vaccination
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批准号:10374945
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项目类别:
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资助金额:$45.24万
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财政年份:2019
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负责人:Alessandro Sette
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依托单位:
Administrative Core
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批准号:10321620
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项目类别:
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资助金额:$0.65万
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财政年份:2018
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负责人:Alessandro Sette
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依托单位:
Autoimmune features of neurodegenerative disorders
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批准号:9975948
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项目类别:
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资助金额:$83.95万
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财政年份:2018
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依托单位:
Autoimmune features of neurodegenerative disorders
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批准号:10214704
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项目类别:
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资助金额:$80.46万
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财政年份:2018
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依托单位:
Cockroach and mouse allergy T cell phenotypes and their correlation with clinical status
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批准号:10321623
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项目类别:
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资助金额:$35.28万
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财政年份:2018
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依托单位:
Autoimmune features of neurodegenerative disorders
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批准号:10452771
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项目类别:
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资助金额:$77.62万
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财政年份:2018
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负责人:Alessandro Sette
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依托单位:
LJI Epitope Validation Center: Characterization of epitope-specific T cells responding to food, fungal and inner city allergens
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批准号:10321619
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项目类别:
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资助金额:$115.36万
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财政年份:2018
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负责人:Alessandro Sette
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依托单位:
Autoimmune features of neurodegenerative disorders
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批准号:9789382
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项目类别:
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资助金额:$84.4万
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财政年份:2018
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负责人:Alessandro Sette
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依托单位:
国内基金
海外基金
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依托单位: