Mentoring Investigators on the Clinical Translation of Genetic Discoveries in Type 2 Diabetes

指导研究人员将基因发现应用于 2 型糖尿病的临床转化

• 批准号: 9334188
• 负责人: JOSE CARLOS FLOREZ
• 金额: $ 16.24万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2021-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9334188
• 关键词: Animal Model; Attention; Big Data; Biological; Clinical; Collaborations; Complex; Data; Data Set; Development; Diabetes Mellitus; Disease; Environment; Explosion; General Hospitals; Genetic Research; Genetic Translation; Genomics; Goals; Health; Human; Human Genetics; Individual; Institutes; International; Investigation; Knowledge; Lead; Life; Massachusetts; Medical; Medicine; Mentors; Metabolic; Mining; Non-Insulin-Dependent Diabetes Mellitus; Participant; Physiological; Positioning Attribute; Preventive; Process; Public Health; Research; Research Infrastructure; Research Personnel; Resources; Scientist; System; Technology; Testing; Therapeutic; Time; Training; Translating; analytical tool; clinical investigation; clinical translation; clinically actionable; clinically relevant; empowered; experience; genomic data; improved; improved outcome; investigator training; medical schools; member; metabolic phenotype; metabolomics; mid-career faculty; outcome prediction; patient oriented; patient oriented research; public health intervention; repository; skills; training opportunity; trait

ABSTRACT We are entering a new era in which the explosion of genomic and biological information across multiple developmental and metabolic states is poised to transform the practice of medicine. The clinician's ability to absorb, assimilate and translate this information will determine the extent of its impact on public health. There is an urgent need to train clinical and non-clinical scientists who are competent on big biological data, and who can curate, disseminate and implement the clinically actionable findings that emerge from ongoing efforts. The PI on this application has dedicated himself to advance genomic and metabolomic discoveries in type 2 diabetes, and now seeks to mentor a cadre of highly trained investigators who will be enabled and empowered to lead the application of genomic and systems-wide approaches to the clinical setting. To achieve this goal, he will 1) establish an infrastructure of pertinent genomic and physiologic datasets available for mining, 2) develop a rigorous yet nurturing training pipeline of carefully selected mentees, and 3) guide the investigation of clinically relevant hypotheses that can be tested in the appropriate environment. Dr. Florez is embedded in a successful and productive milieu that embraces a culture of collaboration. As the Chief of the Diabetes Unit and member of the Center for Human Genetic Research at the Massachusetts General Hospital, an Associate Professor at Harvard Medical School, and an Institute Member at the Broad Institute, he is placed in a unique position that will enable him and his trainees to benefit from direct access to an unparalleled suite of training resources and datasets germane to the proposed patient-oriented research in type 2 diabetes and its complications.

抽象的 我们正在进入一个基因组和生物信息爆炸的新时代 跨越多种发育和代谢状态有望改变实践 药品。临床医生吸收、消化和翻译这些信息的能力将 确定其对公共健康的影响程度。迫切需要临床和培训 能够胜任大生物数据并且能够策划的非临床科学家， 传播并实施持续努力中产生的临床可行的结果。 该应用程序的 PI 致力于推进基因组学和代谢组学的发展 2 型糖尿病的发现，现在寻求指导一批训练有素的研究人员 谁将被授权领导基因组学和全系统的应用 临床环境的方法。为了实现这一目标，他将1）建立一个基础设施 可用于挖掘的相关基因组和生理数据集，2）开发严格的但 培养精心挑选的受训者的培训渠道，以及3）指导调查 可以在适当的环境中进行测试的临床相关假设。弗洛雷斯博士是 植根于一个成功且富有成效的环境，拥抱协作文化。作为 糖尿病科主任兼人类基因研究中心成员 马萨诸塞州总医院、哈佛医学院副教授、 作为布罗德研究所的研究所成员，他被置于一个独特的位置，这将使他能够 他的学员可以直接获得一套无与伦比的培训资源并从中受益 与拟议的 2 型糖尿病及其以患者为导向的研究密切相关的数据集 并发症。