Equipment Supplement for Discovery of Pharmacogenomic Biomarkers for OATP1B1 and OATP1B3

用于发现 OATP1B1 和 OATP1B3 药物基因组生物标志物的设备补充

• 批准号: 10797707
• 负责人: JOSE CARLOS FLOREZ
• 金额: $ 2.94万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-25 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10797707
• 关键词: Award; Biological Markers; Equipment; Funding; Parents; Pharmacogenomics; Research

The abstract of the funded parent award is contained in the 2 page Research Strategy attachment required under NOT-GM-22-017. (See Research Strategy Section).

资助家长奖的摘要包含在所需的2页研究战略附件中 在NOT-GM-22-017下。(见研究战略部分)。

项目成果

Genome-Wide Association Study Identifies Pharmacogenomic Variants Associated With Metformin Glycemic Response in African American Patients With Type 2 Diabetes.

全基因组关联研究确定了与非裔美国 2 型糖尿病患者二甲双胍血糖反应相关的药物基因组变异。

• DOI: 10.2337/dc22-2494
• 发表时间: 2024
• 期刊: Diabetes care
• 影响因子: 16.2
• 作者: Wu,Baojun;Yee,SookWah;Xiao,Shujie;Xu,Fei;Sridhar,SnehaB;Yang,Mao;Hochstadt,Samantha;Cabral,Whitney;Lanfear,DavidE;Hedderson,MoniqueM;Giacomini,KathleenM;Williams,LKeoki
• 通讯作者: Williams,LKeoki

A roadmap to achieve pharmacological precision medicine in diabetes.

• DOI: 10.1007/s00125-022-05732-3
• 发表时间: 2022-11
• 期刊: DIABETOLOGIA
• 影响因子: 8.2
• 作者: Florez, Jose C.;Pearson, Ewan R.
• 通讯作者: Pearson, Ewan R.

Unveiling the Genetic Architecture of Human Disease for Precision Medicine.

揭示精准医学人类疾病的遗传结构。

• DOI: 10.1111/cts.12593
• 发表时间: 2019
• 期刊: Clinical and translational science
• 作者: Ramamoorthy,Anuradha;Yee,SookWah;Karnes,Jason
• 通讯作者: Karnes,Jason

Unraveling the functional role of the orphan solute carrier, SLC22A24 in the transport of steroid conjugates through metabolomic and genome-wide association studies.

通过代谢组学和全基因组关联研究，揭示孤儿溶质载体 SLC22A24 在类固醇缀合物转运中的功能作用。

• DOI: 10.1371/journal.pgen.1008208
• 发表时间: 2019
• 期刊: PLoS genetics
• 影响因子: 4.5
• 作者: Yee,SookWah;Stecula,Adrian;Chien,Huan-Chieh;Zou,Ling;Feofanova,ElenaV;vanBorselen,Marjolein;Cheung,KitWunKathy;Yousri,NohaA;Suhre,Karsten;Kinchen,JasonM;Boerwinkle,Eric;Irannejad,Roshanak;Yu,Bing;Giacomini,KathleenM
• 通讯作者: Giacomini,KathleenM

Drugs in COVID-19 Clinical Trials: Predicting Transporter-Mediated Drug-Drug Interactions Using In Vitro Assays and Real-World Data.

• DOI: 10.1002/cpt.2236
• 发表时间: 2021-07
• 期刊: Clinical pharmacology and therapeutics
• 影响因子: 6.7
• 作者: Yee SW;Vora B;Oskotsky T;Zou L;Jakobsen S;Enogieru OJ;Koleske ML;Kosti I;Rödin M;Sirota M;Giacomini KM
• 通讯作者: Giacomini KM