Effects of White and Gray Matter Integrity on Cognition in A Multi-Ethnic Cohort

白质和灰质完整性对多种族群体认知的影响

• 批准号: 9396467
• 负责人: Michelle Rae Caunca
• 金额: $ 4.9万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-01 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9396467
• 关键词: Address; Adult; Affect; African American; Age-associated memory impairment; Aging; Anatomy; Area; Axon; BRAIN initiative; Basic Science; Blood Vessels; Brain; Brain Injuries; Brain region; Caucasians; Cerebrovascular Disorders; Cerebrum; Clinical; Clinical Markers; Clinical Research; Cognition; Cognition Disorders; Communities; Data; Diffusion; Elderly; Equation; Goals; Hispanics; Impaired cognition; Intervention; Investments; Latino; Lead; Lesion; Linear Regressions; Magnetic Resonance Imaging; Measurement; Mediating; Minority; Modeling; Modification; National Institute of Neurological Disorders and Stroke; Nerve Degeneration; Not Hispanic or Latino; Pathology; Pathway interactions; Pattern; Population; Populations at Risk; Prevention; Process; Public Health; Research; Risk; Risk Factors; Strategic Planning; Stroke; Testing; Thick; Translational Research; United States National Institutes of Health; White Matter Disease; White Matter Hyperintensity; aged; base; cerebrovascular; cognitive performance; cohort; ethnic minority population; frontal lobe; gray matter; high risk; myelin degeneration; nervous system disorder; racial minority; vascular risk factor; water diffusion; white matter; white matter damage

Project Summary Age-related cognitive impairment in racial and ethnic minorities is one of the most important public health issues in the US. The number of adults aged sixty-five and older is expected to double in the next four decades, and the proportion of Hispanic/Latino or non-Hispanic black older adults is also expected to increase rapidly. Hispanics/Latinos and non-Hispanic blacks have a greater risk of cognitive impairment compared to non-Hispanic whites, which could be due to a greater burden of vascular risk factors in these groups. Vascular risk factors may influence macro- and microstructural WM integrity, which may in turn damage gray matter (GM) integrity and lead to cognitive impairment. Though global metrics of WM integrity, such as white matter hyperintensity volume (WMHV), have been associated with cognition extensively, growing evidence suggests that WMHV does not reflect the full extent of WM disease. Recent studies propose that a penumbra of WM damage exists outside of WMH and is better reflected by metrics of microstructural WM integrity. Despite these findings, the relationships between macro- and microstructural WM integrity, GM integrity, and cognition are not well understood in Hispanic/Latino and non-Hispanic black populations with a greater vascular risk factor burden and increased risk for cerebrovascular and cognitive disease as compared to Caucasians. In this proposed study, I will investigate the associations between macro- and microstructural WM integrity, GM integrity, and cognition in the mostly Hispanic/Latino, clinically stroke-free Northern Manhattan Study (NOMAS). The central hypotheses are that MRI-derived, region-specific metrics of macro- and microstructural WM integrity predict cognitive performance, and region-specific metrics of GM integrity partially mediate this association. I also hypothesize that metrics of microstructural WM integrity will associate with cognition independently from and more robustly than metrics of macrostructural WM integrity. Results from this proposed study will provide evidence for potential targets for intervention in these at-risk populations. These study aims support key goals of the National Institute of Neurological Disorders and Stroke (NINDS) Strategic Plan, including: a) investment across the full spectrum of basic, translational, and clinical research; b) promotion of clinical research; and c) establishment of a data-driven process to identify unmet scientific opportunities and public health need within and across neurological disease. The proposed research also addresses the NIH BRAIN Initiative by exploring brain networks through MRI metrics of WM integrity.

项目摘要 与年龄相关的认知障碍在种族和少数民族中是最重要的公共健康之一 美国的问题。在接下来的四年里，65岁以上的成年人的数量预计将翻一番 几十年，西班牙裔/拉丁裔或非西班牙裔黑人老年人的比例预计也将增加 迅速地。拉美裔/拉丁裔和非拉美裔黑人患认知障碍的风险比 非西班牙裔白人，这可能是由于这些群体中血管风险因素的更大负担。血管 风险因素可能影响宏观和微观白质结构的完整性，进而可能损害灰质。 (GM)正直和导致认知障碍。尽管WM完整性的全球指标，如白质 越来越多的证据表明，高强度体积(WMHV)与认知广泛相关 WMHV不能反映WM疾病的全部范围。最近的研究表明，西医的半暗带 损伤存在于WMH之外，微结构WM完整性度量能更好地反映损伤。尽管如此 研究发现，宏观和微观结构的WM完整性、GM完整性和认知之间的关系是 在血管风险因素较大的西班牙裔/拉丁裔和非西班牙裔黑人人群中未得到很好的理解 与高加索人相比，高加索人患脑血管疾病和认知疾病的负担和风险增加。在这 拟议的研究，我将调查宏观和微观结构的WM完整性之间的联系，GM 以西班牙裔/拉丁裔为主、临床上没有中风的曼哈顿北部研究中的完整性和认知 (NOMAS)。中心假设是MRI衍生的、区域特定的宏观和微观结构指标 WM完整性预测认知表现，而GM完整性的区域特定指标部分地中介了这一点 协会。我还假设，微结构工作记忆完整性的指标将与认知联系在一起 独立于并比宏观结构WM完整性的指标更强健。这项建议的结果 这项研究将为这些高危人群的潜在干预目标提供证据。 这些研究旨在支持国家神经疾病和中风研究所(NINDS)的主要目标 战略计划，包括：a)对基础研究、翻译研究和临床研究的全方位投资；b) 促进临床研究；以及c)建立一个数据驱动的程序，以确定未满足的科学研究 神经疾病内部和跨领域的机会和公共卫生需求。拟议的研究还包括 通过WM完整性的MRI指标探索大脑网络，解决NIH大脑倡议。