Training program in the neurology of language and neurodegenerative aphasias

语言神经病学和神经退行性失语症培训计划

• 批准号: 9307799
• 负责人: MARIA LUISA GORNO TEMPINI
• 金额: $ 18.65万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2021-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9307799
• 关键词: Aging; Alzheimer' s Disease; Amyloid beta-Protein; Amyloid deposition; Anatomy; Anterior; Aphasia; Atrophic; Award; Behavioral; Brain; Cessation of life; Characteristics; Classification Scheme; Clinical; Clinical Sciences; Cognitive; Collection; Data; Dementia; Deposition; Development; Development Plans; Diagnostic; Diffuse; Dyslexia; Educational process of instructing; Educational workshop; Frontotemporal Lobar Degenerations; Genetic; Goals; Grant; Heterogeneity; Human; Image; Individual; Inferior; Institutes; Journals; Knowledge; Language; Language Development; Language Disorders; Learning Disabilities; Left; Life; Location; Magnetic Resonance Imaging; Medial; Memory; Mentors; Methodology; Modeling; Modernization; Molecular; Monitor; Motor; Names; Nerve Degeneration; Neurobiology; Neurodegenerative Disorders; Neurologic; Neurologist; Neurology; Neurosciences; Parietal; Pathogenesis; Pathologic; Pathology; Patients; Pattern; Performance; Phenotype; Population; Positron-Emission Tomography; Predisposition; Prevalence; Prevalence Study; Primary Progressive Aphasia; Proteins; Recording of previous events; Research; Research Personnel; Research Project Grants; Resources; Scientist; Semantics; Speech; Speech Pathology; Structure; Symptoms; Syndrome; System; Techniques; Testing; Time; Tracer; Training; Training Programs; Translational Research; Variant; Work; amyloid imaging; base; cognitive neuroscience; cohort; diagnostic accuracy; experience; imaging study; improved; in vivo; interest; lectures; molecular imaging; multidisciplinary; neuroimaging; next generation; novel; patient oriented research; phonology; programs; prospective; relating to nervous system; success; symptomatology; tau Proteins; tau aggregation

ABSTRACT This grant is being requested to support the mentoring activities of Dr. Maria Luisa Gorno Tempini, a behavioral neurologist and cognitive neuroscientist. Dr. Gorno Tempini is a leader researcher and clinician in the fields of neurology and neuroscience of language, with specific expertise in atypical neurodegenerative diseases that present as language disorders. Her research has concentrated on primary progressive aphasia (PPA), and used cognitive neuroscience and advanced neuroimaging techniques to study its clinical variants and the neural basis of language symptoms. Dr. Gorno-Tempini has a proven commitment and a track record of success in mentoring both clinicians and scientists in patient-oriented research (POR) related to language disorders. The goals of this proposal are: 1) to support time for Dr. Gorno Tempini to mentor a growing number of clinicians and researchers interested in language and neurodegenerative disorders; 2) to support time to build a structured teaching and mentoring program, and to become a leading mentor at UCSF; and 3) to pursue novel lines of research in PPA that her mentees may participate in. To accomplish these goals, she will build a formal mentoring program using the excellent resources available at the UCSF Memory and Aging, Dyslexia, and Sandler Neuroscience Centers, and at the UCSF Clinical and Translational Science Institute. Dr. Gorno- Tempini's mentees will train through planned didactics, such as lectures, workshops, journal clubs and one-on- one sessions, and their progress will be monitored using Individual Development Plans. Dr. Gorno-Tempini's experience in basic cognitive neuroscience and neurological methodologies gives her unique multidisciplinary expertise that can benefit trainees with backgrounds in neurology, neuroscience, and speech pathology. The research project proposed here will investigate prospectively the prevalence of neurodevelopmental differences in PPA, and will determine the effect of language-based learning disabilities on the PPA phenotype. Furthermore, she will apply novel molecular neuroimaging techniques to study the distribution of tau in the living brain of patients with PPA. The study will improve our knowledge of PPA presentation and provide data on the selective vulnerability of language networks to neurodegenerative diseases. This grant will be instrumental in supporting the pursuit of Dr. Gorno-Tempini's goals to mentor the next generation of clinician scientists in the neurology of language and neurodegenerative aphasias.

抽象的 该赠款被要求支持玛丽亚·路易莎·戈尔诺·坦皮尼（Maria Luisa Gorno Tempini）的指导活动 行为神经科医生和认知神经科学家。 Gorno Tempini博士是领导者研究员和临床医生 语言的神经学和神经科学领域，具有非典型神经退行性的特定专业知识 作为语言疾病的疾病。她的研究集中于主要的进行性失语症 （PPA），并使用认知神经科学和高级神经影像学技术来研究其临床变体 以及语言症状的神经基础。 Gorno-Tempini博士具有可靠的承诺和记录 在指导临床医生和科学家方面取得成功的与语言有关的研究（POR） 疾病。 该提案的目标是：1）支持Gorno Tempini博士指导越来越多的时间 对语言和神经退行性疾病感兴趣的临床医生和研究人员； 2）支持构建时间 一个结构化的教学和指导计划，并成为UCSF的主要导师； 3）追求 她的受训者可能会参与PPA的新型研究。为了实现这些目标，她将建立一个 使用UCSF内存和衰老，阅读障碍的优质资源的正式指导计划， 以及桑德勒神经科学中心，以及UCSF临床和转化科学研究所。戈尔诺博士 Tempini的受训者将通过计划的教学训练，例如讲座，讲习班，期刊俱乐部和一对一 一次会议，并将使用个人发展计划来监视他们的进度。 Gorno-Tempini博士 具有基本认知神经科学和神经学方法论的经验使她独特的多学科 具有神经病学，神经科学和言语病理学背景的受训者的专业知识。 这里提出的研究项目将前瞻性地研究神经发育的患病率 PPA的差异将决定基于语言的学习障碍对PPA表型的影响。 此外，她将应用新颖的分子神经影像学技术来研究tau在 PPA患者的生活大脑。该研究将提高我们对PPA演示的了解并提供数据 关于语言网络对神经退行性疾病的选择性脆弱性。 这笔赠款将有助于支持Gorno-Tempini博士的目标，以指导下一项 语言和神经退行性失语症神经学的临床医生产生。