Training program in the neurology of language and neurodegenerative aphasias

语言神经病学和神经退行性失语症培训计划

• 批准号: 9307799
• 负责人: MARIA LUISA GORNO TEMPINI
• 金额: $ 18.65万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2021-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9307799
• 关键词: Aging; Alzheimer' s Disease; Amyloid beta-Protein; Amyloid deposition; Anatomy; Anterior; Aphasia; Atrophic; Award; Behavioral; Brain; Cessation of life; Characteristics; Classification Scheme; Clinical; Clinical Sciences; Cognitive; Collection; Data; Dementia; Deposition; Development; Development Plans; Diagnostic; Diffuse; Dyslexia; Educational process of instructing; Educational workshop; Frontotemporal Lobar Degenerations; Genetic; Goals; Grant; Heterogeneity; Human; Image; Individual; Inferior; Institutes; Journals; Knowledge; Language; Language Development; Language Disorders; Learning Disabilities; Left; Life; Location; Magnetic Resonance Imaging; Medial; Memory; Mentors; Methodology; Modeling; Modernization; Molecular; Monitor; Motor; Names; Nerve Degeneration; Neurobiology; Neurodegenerative Disorders; Neurologic; Neurologist; Neurology; Neurosciences; Parietal; Pathogenesis; Pathologic; Pathology; Patients; Pattern; Performance; Phenotype; Population; Positron-Emission Tomography; Predisposition; Prevalence; Prevalence Study; Primary Progressive Aphasia; Proteins; Recording of previous events; Research; Research Personnel; Research Project Grants; Resources; Scientist; Semantics; Speech; Speech Pathology; Structure; Symptoms; Syndrome; System; Techniques; Testing; Time; Tracer; Training; Training Programs; Translational Research; Variant; Work; amyloid imaging; base; cognitive neuroscience; cohort; diagnostic accuracy; experience; imaging study; improved; in vivo; interest; lectures; molecular imaging; multidisciplinary; neuroimaging; next generation; novel; patient oriented research; phonology; programs; prospective; relating to nervous system; success; symptomatology; tau Proteins; tau aggregation

ABSTRACT This grant is being requested to support the mentoring activities of Dr. Maria Luisa Gorno Tempini, a behavioral neurologist and cognitive neuroscientist. Dr. Gorno Tempini is a leader researcher and clinician in the fields of neurology and neuroscience of language, with specific expertise in atypical neurodegenerative diseases that present as language disorders. Her research has concentrated on primary progressive aphasia (PPA), and used cognitive neuroscience and advanced neuroimaging techniques to study its clinical variants and the neural basis of language symptoms. Dr. Gorno-Tempini has a proven commitment and a track record of success in mentoring both clinicians and scientists in patient-oriented research (POR) related to language disorders. The goals of this proposal are: 1) to support time for Dr. Gorno Tempini to mentor a growing number of clinicians and researchers interested in language and neurodegenerative disorders; 2) to support time to build a structured teaching and mentoring program, and to become a leading mentor at UCSF; and 3) to pursue novel lines of research in PPA that her mentees may participate in. To accomplish these goals, she will build a formal mentoring program using the excellent resources available at the UCSF Memory and Aging, Dyslexia, and Sandler Neuroscience Centers, and at the UCSF Clinical and Translational Science Institute. Dr. Gorno- Tempini's mentees will train through planned didactics, such as lectures, workshops, journal clubs and one-on- one sessions, and their progress will be monitored using Individual Development Plans. Dr. Gorno-Tempini's experience in basic cognitive neuroscience and neurological methodologies gives her unique multidisciplinary expertise that can benefit trainees with backgrounds in neurology, neuroscience, and speech pathology. The research project proposed here will investigate prospectively the prevalence of neurodevelopmental differences in PPA, and will determine the effect of language-based learning disabilities on the PPA phenotype. Furthermore, she will apply novel molecular neuroimaging techniques to study the distribution of tau in the living brain of patients with PPA. The study will improve our knowledge of PPA presentation and provide data on the selective vulnerability of language networks to neurodegenerative diseases. This grant will be instrumental in supporting the pursuit of Dr. Gorno-Tempini's goals to mentor the next generation of clinician scientists in the neurology of language and neurodegenerative aphasias.

摘要 申请这笔赠款是为了支持一位名叫玛丽亚·路易莎·戈尔诺·滕皮尼的妇女的辅导活动。 行为神经学家和认知神经学家。Gorno Tempini博士是一位领导研究者和临床医生， 语言的神经学和神经科学领域，具有非典型神经退行性疾病的特定专业知识 表现为语言障碍的疾病她的研究集中在原发性进行性失语症 (PPA)，并利用认知神经科学和先进的神经影像技术研究其临床变异 以及语言症状的神经基础Gorno-Tempini博士有一个被证明的承诺和记录 成功指导临床医生和科学家进行与语言相关的以患者为导向的研究（POR） 紊乱 该提案的目标是：1）为Gorno Tempini博士提供时间，以指导越来越多的 对语言和神经退行性疾病感兴趣的临床医生和研究人员; 2）支持时间建立 一个结构化的教学和指导计划，并成为一个领先的导师在加州大学旧金山分校;和3）追求 她的学员可能参与的PPA新研究路线。为了实现这些目标，她将建立一个 正式的指导计划，使用优秀的资源，在加州大学旧金山分校的记忆和衰老，诵读困难， 和桑德勒神经科学中心，并在加州大学旧金山分校临床和转化科学研究所。哥诺医生- Tempini的学员将通过计划的教学法进行培训，如讲座，研讨会，期刊俱乐部和一对一的 他们的进展将通过个人发展计划进行监测。Gorno-Tempini医生 在基础认知神经科学和神经学方法方面的经验使她具有独特的多学科 这些专业知识可以使具有神经病学、神经科学和语言病理学背景的学员受益。 本文提出的研究项目将前瞻性地调查神经发育障碍的患病率。 PPA的差异，并将确定基于语言的学习障碍对PPA表型的影响。 此外，她将应用新的分子神经成像技术来研究tau蛋白在脑组织中的分布。 PPA患者的活体大脑。该研究将提高我们对PPA表现的认识，并提供数据 语言网络对神经退行性疾病的选择性脆弱性。 这笔赠款将有助于支持Gorno-Tempini博士追求指导下一个 在语言和神经退行性失语症的神经学临床科学家的一代。