Training program in the neurology of language and neurodegenerative aphasias

语言神经病学和神经退行性失语症培训计划

• 批准号: 9307799
• 负责人: MARIA LUISA GORNO TEMPINI
• 金额: $ 18.65万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2021-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9307799
• 关键词: Aging; Alzheimer' s Disease; Amyloid beta-Protein; Amyloid deposition; Anatomy; Anterior; Aphasia; Atrophic; Award; Behavioral; Brain; Cessation of life; Characteristics; Classification Scheme; Clinical; Clinical Sciences; Cognitive; Collection; Data; Dementia; Deposition; Development; Development Plans; Diagnostic; Diffuse; Dyslexia; Educational process of instructing; Educational workshop; Frontotemporal Lobar Degenerations; Genetic; Goals; Grant; Heterogeneity; Human; Image; Individual; Inferior; Institutes; Journals; Knowledge; Language; Language Development; Language Disorders; Learning Disabilities; Left; Life; Location; Magnetic Resonance Imaging; Medial; Memory; Mentors; Methodology; Modeling; Modernization; Molecular; Monitor; Motor; Names; Nerve Degeneration; Neurobiology; Neurodegenerative Disorders; Neurologic; Neurologist; Neurology; Neurosciences; Parietal; Pathogenesis; Pathologic; Pathology; Patients; Pattern; Performance; Phenotype; Population; Positron-Emission Tomography; Predisposition; Prevalence; Prevalence Study; Primary Progressive Aphasia; Proteins; Recording of previous events; Research; Research Personnel; Research Project Grants; Resources; Scientist; Semantics; Speech; Speech Pathology; Structure; Symptoms; Syndrome; System; Techniques; Testing; Time; Tracer; Training; Training Programs; Translational Research; Variant; Work; amyloid imaging; base; cognitive neuroscience; cohort; diagnostic accuracy; experience; imaging study; improved; in vivo; interest; lectures; molecular imaging; multidisciplinary; neuroimaging; next generation; novel; patient oriented research; phonology; programs; prospective; relating to nervous system; success; symptomatology; tau Proteins; tau aggregation

ABSTRACT This grant is being requested to support the mentoring activities of Dr. Maria Luisa Gorno Tempini, a behavioral neurologist and cognitive neuroscientist. Dr. Gorno Tempini is a leader researcher and clinician in the fields of neurology and neuroscience of language, with specific expertise in atypical neurodegenerative diseases that present as language disorders. Her research has concentrated on primary progressive aphasia (PPA), and used cognitive neuroscience and advanced neuroimaging techniques to study its clinical variants and the neural basis of language symptoms. Dr. Gorno-Tempini has a proven commitment and a track record of success in mentoring both clinicians and scientists in patient-oriented research (POR) related to language disorders. The goals of this proposal are: 1) to support time for Dr. Gorno Tempini to mentor a growing number of clinicians and researchers interested in language and neurodegenerative disorders; 2) to support time to build a structured teaching and mentoring program, and to become a leading mentor at UCSF; and 3) to pursue novel lines of research in PPA that her mentees may participate in. To accomplish these goals, she will build a formal mentoring program using the excellent resources available at the UCSF Memory and Aging, Dyslexia, and Sandler Neuroscience Centers, and at the UCSF Clinical and Translational Science Institute. Dr. Gorno- Tempini's mentees will train through planned didactics, such as lectures, workshops, journal clubs and one-on- one sessions, and their progress will be monitored using Individual Development Plans. Dr. Gorno-Tempini's experience in basic cognitive neuroscience and neurological methodologies gives her unique multidisciplinary expertise that can benefit trainees with backgrounds in neurology, neuroscience, and speech pathology. The research project proposed here will investigate prospectively the prevalence of neurodevelopmental differences in PPA, and will determine the effect of language-based learning disabilities on the PPA phenotype. Furthermore, she will apply novel molecular neuroimaging techniques to study the distribution of tau in the living brain of patients with PPA. The study will improve our knowledge of PPA presentation and provide data on the selective vulnerability of language networks to neurodegenerative diseases. This grant will be instrumental in supporting the pursuit of Dr. Gorno-Tempini's goals to mentor the next generation of clinician scientists in the neurology of language and neurodegenerative aphasias.

摘要 这笔赠款是为了支持玛丽亚·路易莎·戈尔诺·坦皮尼博士的辅导活动，她是一名 行为神经学家和认知神经学家。戈尔诺·坦皮尼博士是一位领先的研究员和临床医生 神经学和语言神经科学领域，具有非典型神经退行性变方面的专门知识 表现为语言障碍的疾病。她的研究集中在原发性进行性失语症上。 (PPA)，并使用认知神经科学和先进的神经成像技术来研究其临床变体 以及语言症状的神经基础。戈尔诺-坦皮尼博士的承诺得到了证实，并有良好的记录 在与语言相关的以患者为中心的研究(POR)中成功地指导临床医生和科学家 精神错乱。 这项提议的目标是：1)支持Gorno Tempini博士有时间指导越来越多的 对语言和神经退行性疾病感兴趣的临床医生和研究人员；2)支持时间建立 有组织的教学和指导计划，并成为加州大学旧金山分校的主要导师；以及3)追求 她的指导者可能参与的PPA的新研究路线。为了实现这些目标，她将建立一个 使用加州大学旧金山分校记忆和衰老、阅读障碍、 和桑德勒神经科学中心，以及加州大学旧金山分校临床和翻译科学研究所。戈尔诺博士- Tempini的学员将通过计划中的教学进行培训，如讲座、研讨会、日记俱乐部和一对一 一次会议，将使用个别发展计划监测其进展情况。戈尔诺-坦皮尼医生的 在基础认知神经科学和神经学方法论方面的经验使她拥有独特的多学科 具有神经学、神经科学和语言病理学背景的受训者可以受益的专业知识。 这里提出的研究项目将前瞻性地调查神经发育的流行率。 PPA的差异，并将决定基于语言的学习障碍对PPA表型的影响。 此外，她将应用新的分子神经成像技术来研究tau在脑内的分布。 PPA患者的活脑。这项研究将提高我们对PPA陈述的了解，并提供数据 关于语言网络对神经退行性疾病的选择性脆弱性。 这笔赠款将有助于支持戈尔诺-坦皮尼博士实现指导下一届 一代神经病学临床科学家研究语言和神经退行性失语症。