Combination HIV Prevention, Linking Prevention and Care, for Hispanic Men
针对西班牙裔男性的艾滋病毒综合预防,将预防与护理联系起来
基本信息
- 批准号:9228394
- 负责人:
- 金额:$ 55.7万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-02-17 至 2020-12-31
- 项目状态:已结题
- 来源:
- 关键词:AIDS preventionAddressAffectAmericasAnusAreaCaringChlamydiaCollaborationsCommunicationCommunitiesCommunity HealthCommunity Health SystemsCommunity HealthcareContinuity of Patient CareCounselingDataDiagnosisDiffuseDisclosureDiscriminationDiseaseDropsEarly DiagnosisElementsEpidemicFaceFrequenciesGaysGeographic LocationsGonorrheaGovernmentHIVHIV InfectionsHIV diagnosisHealthHealth ServicesHealth care facilityHealth systemHealthcareHealthcare SystemsHispanicsHomophobiaHospitalsHuman RightsHuman immunodeficiency virus testIncidenceIndividualInfectionInterventionLatin AmericaLearningLesbian Gay Bisexual TransgenderLinkLongitudinal cohortMethodsModelingPatientsPeruPeruvianPopulationPreventionPrevention programProviderPublic HealthRecruitment ActivityRestRiskRisk ReductionSelf ManagementSexual TransmissionSexually Transmitted DiseasesSiteSocial ChangeSocial supportStressSyndromeTestingUnsafe SexViralbasecare seekingcondomsefficacy testingempoweredempowermenthealth care servicehealth datainnovationliteracymenmen who have sex with menprevention servicepublic health relevancescale upsex riskskillssocialsocial engagementsocial exclusionsocial normsocial stigmasynergismtheoriestransgendertransgender womentransphobiawillingness
项目摘要
DESCRIPTION (provided by applicant): Despite the existence of a government-led HIV prevention program focused on men who have sex with men and transgender women (MSM/TW) for nearly two decades in Peru, HIV incidence among them remains high at 5%, and most (70-75%) HIV+ MSM/TW are unaware of their HIV status. This is similar to the rest of Latin America, where sexual transmission among MSM/TW drives the HIV epidemic. HIV prevention efforts for MSM/TW in Peru are ineffective, in part, because this population remains exposed to high levels of societal discrimination, homophobia and transphobia, because of social norms favoring silence about HIV and sexual risk, and because of lack of cultural competent health services. Moreover, HIV+ MSM/TW face substantial HIV stigma, which affects disclosure of HIV status, willingness to obtain HIV testing and care, and social support. A multilevel intervention approach is needed that addresses factors at the individual, social/community, and health system levels, to facilitate earlier detection of HIV infection; linking, retaining, and re-engagin HIV+ people in care and treatment to achieve viral suppression; sexual risk reduction among both HIV- and HIV+ people; and community mobilization around these issues to provide support for and change social norms and engagement in HIV prevention and treatment. A multilevel approach stressing prevention-care links in the Continuum of Prevention and Care (CPC), is likely to reduce barriers to HIV prevention and care through integrated activities involving both community and health facilities, while creating synergy across the intervention elements. We have developed and piloted Proyecto Orgullo (PO), a multilevel, theory-based intervention that diffuses support for and creates positive social norms around HIV prevention by building a mobilized, empowered MSM/TW community to reduce unsafe sex and promote biannual HIV testing. PO has shown to be acceptable, feasible and potentially effective. In collaboration with the Peruvian Ministry of Health (MoH) and local healthcare facilities, we now propose to develop, implement and test the efficacy of PO+, an extension of PO that will facilitate full engagement in the CPC, and strengthen the linkage between the community and the health system. If shown effective, PO+ can be scaled up throughout Peru with the support of the MoH, and used as a model elsewhere in the Americas, including the US. The project aims are: (1) to create Proyecto Orgullo+ (PO+), a comprehensive, integrated, multilevel intervention that will focus on the CPC; (2) to implement PO+ for 3 years in Lima South, in collaboration with the Peruvian MoH, hospitals that provide HIV care, and HIV testing sites; (3) to evaluate the efficacy of PO+ in affecting the CPC by using: (a) data on the CPC, including sexual risk behavior, HIV testing frequency; incidence of anal Chlamydia and gonorrhea, and engagement in care among HIV+ people, collected through longitudinal cohorts of MSM/TW in Lima South and Lima East (the control area), recruited independently of the intervention, oversampling HIV+ MSM/TW; and (b) CD4 and VL data for HIV patients, collected and provided by the MoH.
描述(由申请人提供):尽管秘鲁近20年来一直存在以男男性行为者和变性人女性(MSM/TW)为重点的政府主导的艾滋病毒预防计划,但他们中的艾滋病毒发病率仍然高达5%,大多数(70%-75%)HIV+MSM/TW不知道他们的艾滋病毒状况。这与拉丁美洲其他地区类似,在那里,MSM/TW之间的性传播推动了艾滋病毒的流行。在秘鲁,男男性接触者/男男性接触者预防艾滋病毒的努力无效,部分原因是,由于社会规范倾向于对艾滋病毒和性风险保持沉默,以及缺乏有文化能力的卫生服务,这部分人口仍然面临高度的社会歧视、同性恋恐惧症和变性者恐惧症。此外,HIV+MSM/TW面临着严重的艾滋病毒污名,这影响了艾滋病毒状况的披露、获得艾滋病毒检测和护理的意愿以及社会支持。需要采取多层次的干预办法,处理个人、社会/社区和卫生系统层面的因素,以促进艾滋病毒感染的早期发现;将艾滋病毒携带者与艾滋病毒携带者联系、保留和重新参与护理和治疗,以实现病毒抑制;减少艾滋病毒携带者和艾滋病毒携带者的性风险;围绕这些问题动员社区,支持和改变社会规范以及参与艾滋病毒预防和治疗。在预防和护理连续体系中强调预防-护理联系的多层次方法,可能会通过社区和卫生设施参与的综合活动减少艾滋病毒预防和护理的障碍,同时在干预要素之间产生协同作用。我们开发并试行了Proyecto Orgulo(PO),这是一种基于理论的多层次干预措施,通过建立一个动员起来的、赋权的MSM/TW社区来传播对艾滋病毒预防的支持并围绕其创造积极的社会规范,以减少不安全的性行为并促进一年两次的艾滋病毒检测。事实证明,《条例》是可以接受的、可行的,而且可能是有效的。我们现在建议与秘鲁卫生部和当地医疗机构合作,开发、实施和测试PO+的效果,PO+是PO的延伸,将有助于充分参与方案规划,并加强社区和医疗系统之间的联系。如果证明有效,PO+可以在卫生部的支持下在秘鲁各地扩大规模,并在包括美国在内的美洲其他地区用作样板。该项目的目标是:(1)创建Proyecto Orgulo+(PO+),这是一个全面、综合、多层次的干预措施,将侧重于CPC;(2)与秘鲁卫生部、提供艾滋病毒护理的医院和艾滋病毒检测地点合作,在利马南部实施PO+3年;(3)通过使用:(A)关于CPC的数据,包括性危险行为、艾滋病毒检测频率,评估PO+影响CPC的效果;通过独立于干预措施招募的利马南部和利马东部(对照地区)男男性接触者/男男性接触者的纵向队列收集的肛门衣原体和淋病的发病率以及艾滋病毒感染者中的护理参与度;以及(B)由卫生部收集和提供的艾滋病毒感染者的CD4和VL数据。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Carlos F. Caceres其他文献
Evaluation of a minimal array of emTreponema pallidum/em antigens as biomarkers for syphilis diagnosis, infection staging, and response to treatment
评估一个最小的梅毒螺旋体抗原阵列作为梅毒诊断、感染分期和治疗反应的生物标志物
- DOI:
10.1128/spectrum.03466-23 - 发表时间:
2023-12-05 - 期刊:
- 影响因子:3.800
- 作者:
Austin M. Haynes;Kelika A. Konda;Emily Romeis;Janet Siebert;Silver K. Vargas;Michael Reyes Diaz;Amber Phan;Carlos F. Caceres;Lorenzo Giacani;Jeffrey D. Klausner;Cecilia M. Thompson - 通讯作者:
Cecilia M. Thompson
Correction to: Brief intervention to prevent HIV, STI and unintended pregnancies: preliminary results of a feasibility study from the perspective of healthcare providers in Peru
- DOI:
10.1186/s12913-021-07417-w - 发表时间:
2021-12-01 - 期刊:
- 影响因子:3.000
- 作者:
Jean Pierre Jiron;Clara Sandoval;Juan Carlos Enciso;Ana Sofía De Vasconcelos;Karel Blondeel;Nataliia Bakunina;Galina Lesco;Igor Toskin;Rob Stephenson;Carlos F. Caceres - 通讯作者:
Carlos F. Caceres
Correction to: HIV Risk Perception and Pre-Exposure Prophylaxis (PrEP) Awareness Among Transgender Women from Mexico
- DOI:
10.1007/s10461-022-03887-z - 发表时间:
2022-11-08 - 期刊:
- 影响因子:2.400
- 作者:
Centli Guillen-Diaz-Barriga;Dulce Diaz-Sosa;Thiago S. Torres;Kelika A. Konda;Rebeca Robles-Garcia;Brenda Hoagland;Marcos Benedetti;Cristina Pimenta;Beatriz Grinsztejn;Carlos F. Caceres;Valdilea G. Veloso;Hamid Vega-Ramirez - 通讯作者:
Hamid Vega-Ramirez
Baseline variables associated with subsequent HIV seroconversion among gay, bisexual and other men who have sex with men and transgender women: a prospective, multicenter PrEP demonstration study (ImPrEP)
男同性恋、双性恋及其他男男性行为者和跨性别女性中与后续艾滋病病毒血清转化相关的基线变量:一项前瞻性、多中心暴露前预防示范研究(ImPrEP)
- DOI:
10.1016/j.lana.2025.101098 - 发表时间:
2025-06-01 - 期刊:
- 影响因子:7.600
- 作者:
Carlos F. Caceres;Heather Pines;Kelika A. Konda;Annick Borquez;Ronaldo Moreira;Iuri Leite;Pedro Amparo;Marcelo Cunha;Thiago S. Torres;Juan V. Guanira;Jean-Pierre Jirón;Brenda Hoagland;Heleen Vermandere;Marcos Benedetti;Hamid Vega;Carlos M. Benites;Cristina Pimenta;Beatriz Grinztejn;Valdiléa Veloso;J. David Urbaez-Brito;Karen Campos - 通讯作者:
Karen Campos
Laboratory evaluation of oral fluid for syphilis screening among clinic users from Lima, Peru
秘鲁利马门诊患者口腔液用于梅毒筛查的实验室评估
- DOI:
10.1128/spectrum.01298-24 - 发表时间:
2024-12-06 - 期刊:
- 影响因子:3.800
- 作者:
Jazmin Qquellon;Silver K. Vargas;Francesca Vasquez;E. Michael Reyes-Diaz;Kelika A. Konda;Carlos F. Caceres;Jeffrey D. Klausner - 通讯作者:
Jeffrey D. Klausner
Carlos F. Caceres的其他文献
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{{ truncateString('Carlos F. Caceres', 18)}}的其他基金
Syphilis Immunology and Biology to Improve Clinical Management and Vaccine Design
梅毒免疫学和生物学改善临床管理和疫苗设计
- 批准号:
10392824 - 财政年份:2018
- 资助金额:
$ 55.7万 - 项目类别:
Syphilis Immunology and Biology to Improve Clinical Management and Vaccine Design
梅毒免疫学和生物学改善临床管理和疫苗设计
- 批准号:
10239030 - 财政年份:2018
- 资助金额:
$ 55.7万 - 项目类别:
Combination HIV Prevention, Linking Prevention and Care, for Hispanic Men
针对西班牙裔男性的艾滋病毒综合预防,将预防与护理联系起来
- 批准号:
9883848 - 财政年份:2016
- 资助金额:
$ 55.7万 - 项目类别:
DEVELOPING A STATE-OF-THE-ART COMBINATION HIV PREVENTION PROGRAM FOR MSM/TRANSWOM
为 MSM/TRANSWOM 制定最先进的 HIV 联合预防计划
- 批准号:
8603393 - 财政年份:2013
- 资助金额:
$ 55.7万 - 项目类别:
Planning a Strategic HIV Population Science Training Grant in Peru
规划秘鲁艾滋病毒人口科学战略培训补助金
- 批准号:
8516318 - 财政年份:2013
- 资助金额:
$ 55.7万 - 项目类别:
DEVELOPING A STATE-OF-THE-ART COMBINATION HIV PREVENTION PROGRAM FOR MSM/TRANSWOM
为 MSM/TRANSWOM 制定最先进的 HIV 联合预防计划
- 批准号:
8733757 - 财政年份:2013
- 资助金额:
$ 55.7万 - 项目类别:
Planning a Strategic HIV Population Science Training Grant in Peru
规划秘鲁艾滋病毒人口科学战略培训补助金
- 批准号:
8709014 - 财政年份:2013
- 资助金额:
$ 55.7万 - 项目类别:
Syphilis: Translating technology to understand a neglected epidemic
梅毒:利用技术来了解一种被忽视的流行病
- 批准号:
9124707 - 财政年份:2012
- 资助金额:
$ 55.7万 - 项目类别:
Syphilis: Translating technology to understand a neglected epidemic
梅毒:利用技术来了解一种被忽视的流行病
- 批准号:
8515276 - 财政年份:2012
- 资助金额:
$ 55.7万 - 项目类别:
Syphilis: Translating technology to understand a neglected epidemic
梅毒:利用技术来了解一种被忽视的流行病
- 批准号:
8906723 - 财政年份:2012
- 资助金额:
$ 55.7万 - 项目类别:
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