District of Columbia Center for AIDS Research (DC CFAR)

 描述(由申请人提供)：此申请表描述了我们关于建立哥伦比亚特区艾滋病研究中心(DC CFAR)的建议，该中心建立在过去十年间我们最初建立的DC艾滋病毒/艾滋病研究所(DC HIV/AIDS Institute)和随后的2010-2014年发展CFAR的强大科学和行政基础上。DC CFAR代表了一种独特的“全市”模式，它联合了华盛顿特区六大学术艾滋病毒/艾滋病研究机构--乔治华盛顿大学、乔治敦大学、霍华德大学、美国大学、国家儿童医学中心和退伍军人事务医学中心--的互补科学努力，并与政府和社区合作伙伴密切合作。华盛顿特区的艾滋病毒流行是美国最严重的疫情之一，有16,000多人感染艾滋病毒/艾滋病，所有成年人的艾滋病毒流行率为2.5%，黑人男子的艾滋病毒流行率为5.7%。DC D-CFAR旨在帮助解决针对当地疫情的次优应对措施，它对华盛顿特区的艾滋病毒科学格局产生了革命性的影响--帮助为应对当地疫情的公共卫生反应提供信息，成功地竞争了许多NIH奖项和行政补充，并招募和支持了一大批高级和早期艾滋病毒调查人员。然而，尽管最近在减少新报告的艾滋病毒病例数量方面取得了进展，哥伦比亚特区每天仍有近两例新的艾滋病毒病例被诊断出来。华盛顿特区CFAR的使命是扩大我们的多机构努力，与政府和社区合作，支持有助于结束华盛顿特区及其他地区艾滋病毒流行的研究。DC CFAR的具体目标是：1)提供科学领导和机构基础设施，以推动华盛顿特区的艾滋病毒研究；2)鼓励和支持创新的、跨学科的和转化性的艾滋病毒研究；3)促进早期、新的和少数族裔艾滋病毒调查人员的开发和招聘；4)通过加强艾滋病毒调查人员之间的沟通和合作，促进华盛顿特区的艾滋病毒研究。DC CFAR将支持三个主要科学领域的研究：艾滋病毒预防；免疫学、病毒学和发病机制；以及艾滋病毒护理和治疗的优化。这些领域将得到五个成熟核心的支持：行政核心A将提供全面的科学领导和协调；发展核心B将侧重于向早期、少数群体和新的艾滋病毒研究人员提供支持和指导；三个科学核心--基础科学核心C、临床和人口科学核心D以及社会科学和行为科学核心E--将提供服务，支持创新、跨学科和转化研究。最后，DC CFAR将支持两个科学工作组(SWGs)，以促进在两个优先领域的研究：高度受影响人群SWG和治疗SWG。

 DESCRIPTION (provided by applicant): This application describes our proposal to establish the District of Columbia Center for AIDS Research (DC CFAR), building upon the strong scientific and administrative base that we have established over the past decade initially as the DC HIV/AIDS Institute from 2005-2009 and subsequently as a Developmental CFAR from 2010-2014. The DC CFAR represents a unique "city-wide" model which unites the complementary scientific efforts of the six major academic HIV/AIDS research institutions in Washington, DC - George Washington University, Georgetown University, Howard University, American University, the Children's National Medical Center and the Veterans Affairs Medical Center - and works in close collaboration with government and community partners. The HIV epidemic in Washington, DC is one of the most severe in the United States, with more than 16,000 persons living with HIV/AIDS, and an HIV prevalence rate of 2.5% among all adults and 5.7% among black men. Created to help address what had been a suboptimal response to the local epidemic, the DC D-CFAR has had a transformative impact on the HIV scientific landscape in DC -- helping to inform the public health response to the local epidemic, competing successfully for numerous NIH awards and administrative supplements, and recruiting and supporting a large cadre of both senior and early stage HIV investigators. However, despite recent progress in decreasing the number of newly reported HIV cases, nearly two new HIV cases are still diagnosed in DC each day. The Mission of the DC CFAR is to expand our multi-institutional effort to support research that contributes to ending the HIV epidemic in Washington, DC and beyond in partnership with government and community. The Specific Aims of the DC CFAR are: 1) to provide scientific leadership and institutional infrastructure to advance HIV research in Washington, DC; 2) to stimulate and support innovative, interdisciplinary and translational HIV research; 3) to promote the development and recruitment of early stage, new, and women and minority HIV investigators; and 4) to advance HIV research in DC by increasing communication and collaboration among HIV investigators. The DC CFAR will support research in three primary scientific domains: HIV Prevention; Immunology, Virology and Pathogenesis; and Optimization of HIV Care and Treatment. These domains will be supported by five well-established Cores: Administrative Core A will provide overall scientific leadership and coordination; Developmental Core B will focus on providing support and mentorship to early stage, minority and new HIV investigators; and three Scientific Cores, Basic Sciences Core C, Clinical and Population Sciences Core D, and Social and Behavioral Sciences Core E, will provide services to support innovative, interdisciplinary and translational research. Lastly, the DC CFAR will support two Scientific Working Groups (SWGs) to promote research in two priority areas: the Highly Impacted Populations SWG and the Cure SWG.