District of Columbia Center for AIDS Research

哥伦比亚特区艾滋病研究中心

• 批准号: 10417086
• 负责人: Alan Edward Greenberg
• 金额: $ 305.11万
• 依托单位: GEORGE WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-06-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10417086
• 关键词: AIDS prevention; Achievement; Acquired Immunodeficiency Syndrome; Address; Adult; American; Area; Automobile Driving; Award; Basic Science; Behavioral Sciences; Capital; Child; Cities; Clinical; Clinical Sciences; Collaborations; Communication; Communities; Consequentialism; Consultations; Development; District of Columbia; Epidemic; Evaluation; Fostering; Foundations; Funding; Future; Government; Grant; Growth; HIV; HIV diagnosis; Health; Health system; Infrastructure; Institution; Investments; Lead; Leadership; Manuscripts; Medical center; Mentors; Mission; Modeling; Newly Diagnosed; Population Sciences; Positioning Attribute; Prevention; Public Health; Publishing; Reporting; Research; Research Activity; Research Personnel; Research Support; Science; Services; Site Visit; Social Sciences; Underrepresented Minority; United States Department of Veterans Affairs; United States National Institutes of Health; Universities; Update; Vision; Walkers; Washington; Woman; base; black men; community engagement; comorbidity; design; health data; health inequalities; high risk; implementation science; innovation; interdisciplinary approach; meetings; multidisciplinary; pre-exposure prophylaxis; programs; recruit; response; scale up; webinar; working group

OVERALL RESEARCH PLAN PROJECT SUMMARY This renewal application for the District of Columbia Center for AIDS Research (DC CFAR) presents the scientific and public health achievements of the DC CFAR to date, describes our unique citywide, multi- institutional model, underscores the strong leadership and administrative infrastructure upon which the CFAR is built and articulates a vision for our future scientific directions. The DC CFAR includes 227 HIV investigators from eight DC collaborating institutions – George Washington, Georgetown, Howard and American Universities, the Veterans Affairs Medical Center, Children's National Health System, DC Department of Health and Whitman-Walker Health. Our mission is to intensify our multi- institutional effort to promote and support research that contributes to ending the HIV epidemic in Washington, DC and beyond in partnership with government and community. Notable achievements from the previous funding period provide a strong foundation for our future, including a 46% increase in our Funded Research Base (FRB) from $11.6M in 2015 to $17.0M in 2018; over $2.8M in pilot awards granted since 2010; a 761% return on investment on completed pilot awards funded from 2010-2016; and >1,100 Core services provided and 667 HIV-related articles published by DC CFAR investigators from 2015-2019. With substantial institutional support of $2.8M over five years, and numerous scientific and programmatic innovations underway, the DC CFAR is well-positioned to respond to the critical challenges of our local epidemic. The Specific Aims of the DC CFAR are to: Aim 1: Provide scientific leadership and institutional infrastructure to advance HIV research among the eight collaborating DC CFAR institutions; Aim 2: Stimulate and support innovative and consequential HIV research in the basic, clinical, prevention and social and behavioral sciences while promoting an interdisciplinary approach to addressing the NIH high priority scientific HIV focus areas; Aim 3: Drive the development and recruitment of early stage, new, and women and underrepresented minority HIV investigators; and Aim 4: Enhance communication and foster meaningful new collaborations between DC CFAR investigators and academic, government, community and clinical partners. To achieve these aims, the DC CFAR supports five Cores: Administrative to provide scientific leadership and fiscal oversight; Developmental to oversee the pilot awards and mentoring programs; and Basic Sciences, Clinical and Population Sciences, and Social and Behavioral Sciences to provide services to support innovative and multi-disciplinary HIV research. Lastly, the DC CFAR supports two Scientific Working Groups – HIV Cure and the Ending the HIV Epidemic – to galvanize research in these high priority areas.

总体研究 项目摘要 哥伦比亚特区艾滋病研究中心（DC CFAR）的这份更新申请提出了 迄今为止，DC CFAR的科学和公共卫生成就，描述了我们独特的全市范围内，多 体制模式，强调了强有力的领导和行政基础设施， 它为我们未来的科学方向描绘了一个远景。 DC CFAR包括来自八个DC合作机构的227名艾滋病毒调查人员--乔治华盛顿， 乔治城大学、霍华德大学和美国大学、退伍军人事务医疗中心、儿童国家 卫生系统，DC卫生部和惠特曼-沃克健康。我们的使命是加强我们的多- 促进和支持有助于结束华盛顿艾滋病毒流行的研究的机构努力， DC和超越与政府和社区的伙伴关系。前几年取得的显著成就 资助期为我们的未来奠定了坚实的基础，包括我们资助的研究增加了46% 基础（FRB）从2015年的1160万美元增加到2018年的1700万美元;自2010年以来授予的试点奖励超过280万美元; 761% 2010-2016年资助的已完成试点项目的投资回报率;提供的核心服务超过1，100项 DC CFAR调查人员在2015-2019年发表的667篇艾滋病毒相关文章。 在五年内获得了280万美元的大量机构支持， 正在进行的创新，DC CFAR能够很好地应对我们当地的关键挑战， 疫情DC CFAR的具体目标是： 目标1：提供科学领导和体制基础设施，以推动艾滋病毒研究， 八个合作的DC CFAR机构; 目标2：促进和支持基础、临床、 预防和社会及行为科学，同时促进跨学科方法， 解决NIH高度优先的科学艾滋病毒重点领域; 目标3：推动发展和征聘早期、新、妇女和任职人数不足的人员 少数民族艾滋病毒调查员;以及 目标4：加强沟通，促进DC CFAR之间有意义的新合作 研究人员和学术界、政府、社区和临床合作伙伴。 为了实现这些目标，DC CFAR支持五个核心：行政提供科学领导， 财政监督;发展监督试点奖励和指导计划;和基础科学， 临床和人口科学以及社会和行为科学提供服务， 创新和多学科的艾滋病毒研究。最后，DC CFAR支持两个科学工作组- 艾滋病毒治疗和结束艾滋病毒流行-激励在这些高度优先领域的研究。