Clinical Centers (CC) for the NHLBI Prevention and Early Treatment of Acute Lung

NHLBI 急性肺疾病预防和早期治疗临床中心 (CC)

基本信息

  • 批准号:
    9266811
  • 负责人:
  • 金额:
    $ 45.78万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2014
  • 资助国家:
    美国
  • 起止时间:
    2014-06-17 至 2021-04-30
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): The PETAL RFA is an exciting initiative to create a multi-disciplinary network that can develop and conduct multi-center clinical trials to evaluate promising therapies and approaches for preventing and/or treating acute respiratory distress syndrome (ARDS). We propose participation in this network. The lead institution for this proposal is Beth Israel Deaconess Medical Center (BIDMC), and satellite sites are Massachusetts General Hospital (MGH) and the University of Mississippi. In aggregate, our site possesses a uniquely strong track record of pre- existing collaboration between emergency medicine, anesthesiologists and intensive care physicians, as well as between our individual study sites. This experience and expertise directly addresses the intent of the proposal. Our research team has a sustained, proven track record of successful, high-impact studies in sepsis and ARDS spanning emergency medicine, perioperative medicine and critical care. Our site is already serves as the coordinating center for the Lung Injury Prevention Trial with Aspirin (LIPS-A) which is in many ways the prototype for the type of study envisioned for the PETAL network. Thus, we are ideally positioned to create an extremely high-performing PETAL clinical center, as well as to contribute to network leadership and scientific direction. We also submit two proposals for clinical studies to be undertaken by the PETAL network. Both of these studies are based upon strong preliminary data from our institutions. The first study will examine the ability of rosuvastatin to prevent development of ARDS in patients at risk for development of the syndrome. While statin drugs have previously been tested as a treatment for ARDS there is substantial evidence to suggest that they may be more effective as a prevention strategy. This study builds on our success as the clinical coordinating center of the LIPS-A study. Our second proposed study will test the ability of using personalized physiology, the patient's own pleural pressure as measured using esophageal balloons, to set the level of positive end-expiratory pressure in patients with established ARDS. This proposal will support a phase 3 trial of this promising modality. The expertise and experience of the investigators involved in this proposal will allow the BIDMC clinical site to contribute substantially to the scientific success of the PETAL network.
描述(由申请人提供):PETAL RFA是一项令人兴奋的倡议,旨在创建一个多学科网络,可以开发和进行多中心临床试验,以评估预防和/或治疗急性呼吸窘迫综合征(ARDS)的有前途的疗法和方法。我们建议加入这一网络。该提案的牵头机构是贝斯以色列女执事医疗中心(BIDMC),卫星站点是马萨诸塞州总医院(MGH)和密西西比大学。总的来说,我们的研究中心在急诊医学、麻醉师和重症监护医生之间以及我们的各个研究中心之间的预先存在的合作方面拥有独特的良好记录。这种经验和专门知识直接涉及提案的意图。我们的研究团队在败血症和ARDS的成功,高影响力的研究方面拥有持续,可靠的记录,涵盖急诊医学,围手术期医学和重症监护。我们的网站已经成为阿司匹林肺损伤预防试验(LIPS-A)的协调中心,该试验在许多方面都是PETAL网络设想的研究类型的原型。因此,我们处于理想的位置,可以创建一个非常高性能的PETAL临床中心,并为网络领导和科学方向做出贡献。 我们还提交了两项由PETAL网络进行临床研究的建议。这两项研究都是基于我们机构的强有力的初步数据。第一项研究将 检查瑞舒伐他汀预防有发生综合征风险的患者发生ARDS的能力。虽然他汀类药物先前已被测试为治疗ARDS,但有大量证据表明,它们作为预防策略可能更有效。这项研究建立在我们作为LIPS-A研究临床协调中心的成功基础上。我们的第二项研究将测试使用个性化生理学的能力,即使用食管球囊测量患者自身的胸膜压,以设定患有ARDS的患者的呼气末正压水平。该提案将支持这一有希望的模式的第三阶段试验。 参与本提案的研究者的专业知识和经验将使BIDMC临床研究中心能够为PETAL网络的科学成功做出重大贡献。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

NATHAN I SHAPIRO其他文献

NATHAN I SHAPIRO的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('NATHAN I SHAPIRO', 18)}}的其他基金

Optimization of a rapid assay to quantify circulating glycosaminoglycans and identify vascular endotypes of sepsis
优化快速测定以量化循环糖胺聚糖并识别脓毒症的血管内型
  • 批准号:
    10725255
  • 财政年份:
    2023
  • 资助金额:
    $ 45.78万
  • 项目类别:
The Impact of Fluid Resuscitation on Glycocalyx Degradation in Septic Shock
液体复苏对感染性休克中糖萼降解的影响
  • 批准号:
    10004165
  • 财政年份:
    2019
  • 资助金额:
    $ 45.78万
  • 项目类别:
The Impact of Fluid Resuscitation on Glycocalyx Degradation in Septic Shock
液体复苏对感染性休克中糖萼降解的影响
  • 批准号:
    10249980
  • 财政年份:
    2019
  • 资助金额:
    $ 45.78万
  • 项目类别:
Clinical Centers (CC) for the NHLBI Prevention and Early Treatment of Acute Lung
NHLBI 急性肺疾病预防和早期治疗临床中心 (CC)
  • 批准号:
    9063081
  • 财政年份:
    2014
  • 资助金额:
    $ 45.78万
  • 项目类别:
Clinical Centers (CC) for the NHLBI Prevention and Early Treatment of Acute Lung
NHLBI 急性肺疾病预防和早期治疗临床中心 (CC)
  • 批准号:
    8874286
  • 财政年份:
    2014
  • 资助金额:
    $ 45.78万
  • 项目类别:
Clinical Centers (CC) for the NHLBI Prevention and Early Treatment of Acute Lung
NHLBI 急性肺疾病预防和早期治疗临床中心 (CC)
  • 批准号:
    8707060
  • 财政年份:
    2014
  • 资助金额:
    $ 45.78万
  • 项目类别:
Endothelial Cell Signaling and Microcirculatory Flow in Severe Sepsis
严重脓毒症中的内皮细胞信号传导和微循环流动
  • 批准号:
    7839461
  • 财政年份:
    2009
  • 资助金额:
    $ 45.78万
  • 项目类别:
Endothelial Cell Signaling and Microcirculatory Flow in Severe Sepsis
严重脓毒症中的内皮细胞信号传导和微循环流动
  • 批准号:
    7862321
  • 财政年份:
    2008
  • 资助金额:
    $ 45.78万
  • 项目类别:
Endothelial Cell Signaling and Microcirculatory Flow in Severe Sepsis
严重脓毒症中的内皮细胞信号传导和微循环流动
  • 批准号:
    8079099
  • 财政年份:
    2008
  • 资助金额:
    $ 45.78万
  • 项目类别:
Endothelial Cell Signaling and Microcirculatory Flow in Severe Sepsis
严重脓毒症中的内皮细胞信号传导和微循环流动
  • 批准号:
    7634466
  • 财政年份:
    2008
  • 资助金额:
    $ 45.78万
  • 项目类别:

相似海外基金

Acute senescence: a novel host defence counteracting typhoidal Salmonella
急性衰老:对抗伤寒沙门氏菌的新型宿主防御
  • 批准号:
    MR/X02329X/1
  • 财政年份:
    2024
  • 资助金额:
    $ 45.78万
  • 项目类别:
    Fellowship
Transcriptional assessment of haematopoietic differentiation to risk-stratify acute lymphoblastic leukaemia
造血分化的转录评估对急性淋巴细胞白血病的风险分层
  • 批准号:
    MR/Y009568/1
  • 财政年份:
    2024
  • 资助金额:
    $ 45.78万
  • 项目类别:
    Fellowship
Combining two unique AI platforms for the discovery of novel genetic therapeutic targets & preclinical validation of synthetic biomolecules to treat Acute myeloid leukaemia (AML).
结合两个独特的人工智能平台来发现新的基因治疗靶点
  • 批准号:
    10090332
  • 财政年份:
    2024
  • 资助金额:
    $ 45.78万
  • 项目类别:
    Collaborative R&D
Cellular Neuroinflammation in Acute Brain Injury
急性脑损伤中的细胞神经炎症
  • 批准号:
    MR/X021882/1
  • 财政年份:
    2024
  • 资助金额:
    $ 45.78万
  • 项目类别:
    Research Grant
STTR Phase I: Non-invasive focused ultrasound treatment to modulate the immune system for acute and chronic kidney rejection
STTR 第一期:非侵入性聚焦超声治疗调节免疫系统以治疗急性和慢性肾排斥
  • 批准号:
    2312694
  • 财政年份:
    2024
  • 资助金额:
    $ 45.78万
  • 项目类别:
    Standard Grant
Combining Mechanistic Modelling with Machine Learning for Diagnosis of Acute Respiratory Distress Syndrome
机械建模与机器学习相结合诊断急性呼吸窘迫综合征
  • 批准号:
    EP/Y003527/1
  • 财政年份:
    2024
  • 资助金额:
    $ 45.78万
  • 项目类别:
    Research Grant
FITEAML: Functional Interrogation of Transposable Elements in Acute Myeloid Leukaemia
FITEAML:急性髓系白血病转座元件的功能研究
  • 批准号:
    EP/Y030338/1
  • 财政年份:
    2024
  • 资助金额:
    $ 45.78万
  • 项目类别:
    Research Grant
KAT2A PROTACs targetting the differentiation of blasts and leukemic stem cells for the treatment of Acute Myeloid Leukaemia
KAT2A PROTAC 靶向原始细胞和白血病干细胞的分化,用于治疗急性髓系白血病
  • 批准号:
    MR/X029557/1
  • 财政年份:
    2024
  • 资助金额:
    $ 45.78万
  • 项目类别:
    Research Grant
ロボット支援肝切除術は真に低侵襲なのか?acute phaseに着目して
机器人辅助肝切除术真的是微创吗?
  • 批准号:
    24K19395
  • 财政年份:
    2024
  • 资助金额:
    $ 45.78万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
Collaborative Research: Changes and Impact of Right Ventricle Viscoelasticity Under Acute Stress and Chronic Pulmonary Hypertension
合作研究:急性应激和慢性肺动脉高压下右心室粘弹性的变化和影响
  • 批准号:
    2244994
  • 财政年份:
    2023
  • 资助金额:
    $ 45.78万
  • 项目类别:
    Standard Grant
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了