Educating Physician-Neuroscientists: The R25 at UCSF

 描述（由申请人提供）： 教育医师-神经科学家： UCSF 神经病学系在过去 5 年里一直是 UCSF R25 项目的机构赞助商，并且是本次申请更新的主部门。神经病学和神经病理学都通过该计划为杰出的研究培训候选人提供了支持。我们很高兴神经外科致力于成为该计划的积极参与者，并在此次更新申请中得到充分体现。 神经内科在吸引优秀医学生进入神经内科方面有着出色的记录。 2014 年，在美国医学毕业生 250 名申请 10 个成人神经病学职位的申请中，我们很幸运地将所有 10 个职位与排名列表中的前 11 名申请者匹配。该部门渴望培养下一代国家神经病学领导者，我们的神经病学住院医师实习毕业生大量过渡到长期学术职业，担任实验室调查员、临床科学（以患者为基础）调查员和大学临床医生教师。 使命湾校区神经病学研究大楼的启用（见下面的设施）极大地增加了研究实习生的机会以及公共空间中的实验室研究项目与附近研究项目（例如格拉德斯通研究所）之间的合作。知识环境对于学员来说是令人兴奋的。每月举行的多学科会议（例如大脑俱乐部）都会邀请演讲者讨论吸引临床医生和基础科学家的转化科学问题。这些会议之后有机会与具有不同临床和科学兴趣的同事进行非正式交流。 R25 一直是加州大学旧金山分校神经病学和神经病理学领域才华横溢的年轻医师科学家研究技能发展的关键关键。在隔离时代，对职业中期和高级神经科学家的稳定性提出了挑战，R25 已成为一个更加重要的稳定的 NIH 项目，以确保我们最有才华的早期职业神经科学家得到良好的支持。 我们在完成该计划的参与者中的早期记录令人鼓舞。在加州大学旧金山分校完成该项目的四名学员中，所有人都继续从事实验室研究。一个已经获得了K-award资助，一个已经申请了K-award资助并获得了非常有利的分数，另外两个计划在明年申请K-award资助。其中两人获得了 NIH 以外来源的资助（CIRM、Giannini 基金会和阿尔茨海默病研究中心试点资助）。其中一位是与 R25 研究计划相关的同行评审论文的作者，另一位的手稿正在接受审查。两名实习生（一名神经病理学家和一名神经病学家）改变了主意，转而从事制药行业。虽然该计划仍处于早期发展阶段，但很明显，UCS 可以提供培训时间和研究环境，以促进医师科学家的早期研究职业发展。

 DESCRIPTION (provided by applicant): Educating Physician-Neuroscientists: The Department of Neurology at UCSF has been the institutional sponsor for the R25 program at UCSF over the past 5 years and is the home department for this application renewal. Both neurology and neuropathology have supported outstanding research training candidates through this program. We are pleased that the Department of Neurosurgery has committed to becoming an active participant in the program and is well-represented in this renewal application. The Department of Neurology has an excellent record for attracting outstanding medical students destined for neurology. Out of 250 applications from US medical graduates for 10 adult neurology positions in 2014, we were fortunate to match all 10 positions to the top eleven applicants on our rank list. The department aspires to train the next generation of national neurology leaders and our neurology residency graduates transition in high numbers to long term academic careers as laboratory investigators, clinical science (patient- based) investigators, and university-based clinician teachers. The opening of the Neurology Research building at the Mission Bay campus (see facilities below) has resulted in greatly expanded opportunities for research trainees and collaboration between laboratory research programs in a common space and with nearby research programs (e.g.-Gladstone Institute). The intellectual environment is exciting for trainees. Monthly multidisciplinary conferences (e.g.-Brain Club) host speakers who discuss translational science issues that attract both clinicians and bench scientists. These conferences are followed by an opportunity to informally mix with colleagues who have diverse clinical and scientific interests. The R25 has been a crucial linchpin for the development of research skills by our talented young physician-scientists in neurology and neuropathology at UCSF. In the era of sequestration, which has challenged the stability of mid-career and senior neuroscientists, the R25 has become an even more important stable NIH program for ensuring that our most talented early career neuroscientists are well-supported. Our early track record among participants who have completed the program is encouraging. Of four trainees who have completed the program at UCSF, all continue to be engaged in laboratory research. One has received K-award funding, one has applied for K-award funding and received a very favorable score, and the other two plans to apply for K-award funding in the next year. Two have received funding from sources other than NIH (CIRM, Giannini Foundation, and Alzheimer's Disease Research Center Pilot Grant). One is an author on a peer-reviewed papers related to the R25 research program and another has a manuscript under review. Two trainees (one neuropathology and one neurology) had a change of heart and moved to careers in the pharmaceutical industry. While the program is still early in evolution, it is clear that UCS can provide the training time and research environment to foster early research career development for physician-scientists.