Educating Physician-Neuroscientists: The R25 at UCSF

 描述（由申请人提供）：教育医生神经科学家：在UCSF神经病学系一直在UCSF的R25计划在过去5年的机构赞助商，是这个应用程序更新的家庭部门。神经病学和神经病理学都通过该计划支持优秀的研究培训候选人。我们很高兴神经外科部门致力于成为该计划的积极参与者，并在此更新申请中得到充分代表。 神经病学系有吸引优秀的医学生注定为神经病学的良好记录。在2014年美国医学毕业生申请10个成人神经学职位的250份申请中，我们很幸运地将所有10个职位与我们排名榜上的前11名申请人相匹配。该部门渴望培养下一代国家神经病学领导人，我们的神经病学住院医师毕业生大量过渡到长期的学术生涯，如实验室研究人员，临床科学（以患者为基础）研究人员和大学临床医生教师。 在使命湾校区的神经学研究大楼的开放（见下面的设施）大大扩大了研究学员的机会，并在一个共同的空间和附近的研究项目（例如- Gladstone Institute）。智力环境对受训者来说是令人兴奋的。每月举行多学科会议（例如：大脑俱乐部）主办的演讲者谁讨论翻译科学问题，吸引临床医生和板凳科学家。这些会议之后，有机会与具有不同临床和科学兴趣的同事进行非正式交流。 R25一直是我们在UCSF神经病学和神经病理学方面有才华的年轻医生科学家发展研究技能的关键。在隔离时代，这对职业中期和高级神经科学家的稳定性提出了挑战，R25已经成为一个更加重要的稳定的NIH计划，以确保我们最有才华的早期职业神经科学家得到良好的支持。 我们在已完成该计划的参与者中的早期记录令人鼓舞。四名学员谁已经完成了在加州大学旧金山分校的计划，都继续从事实验室研究。一个已经获得了K奖资助，一个已经申请了K奖资助并获得了非常有利的分数，另外两个计划在明年申请K奖资助。其中两个获得了NIH以外的资金来源（CIRM，Giannini基金会和阿尔茨海默病研究中心试点赠款）。一个是与R25研究计划相关的同行评审论文的作者，另一个有一篇正在审查的手稿。两名受训人员（一名神经病理学和一名神经病学）改变了主意，转而从事制药行业的职业。虽然该计划仍处于发展初期，但很明显，UCS可以提供培训时间和研究环境，以促进医生科学家的早期研究职业发展。

 DESCRIPTION (provided by applicant): Educating Physician-Neuroscientists: The Department of Neurology at UCSF has been the institutional sponsor for the R25 program at UCSF over the past 5 years and is the home department for this application renewal. Both neurology and neuropathology have supported outstanding research training candidates through this program. We are pleased that the Department of Neurosurgery has committed to becoming an active participant in the program and is well-represented in this renewal application. The Department of Neurology has an excellent record for attracting outstanding medical students destined for neurology. Out of 250 applications from US medical graduates for 10 adult neurology positions in 2014, we were fortunate to match all 10 positions to the top eleven applicants on our rank list. The department aspires to train the next generation of national neurology leaders and our neurology residency graduates transition in high numbers to long term academic careers as laboratory investigators, clinical science (patient- based) investigators, and university-based clinician teachers. The opening of the Neurology Research building at the Mission Bay campus (see facilities below) has resulted in greatly expanded opportunities for research trainees and collaboration between laboratory research programs in a common space and with nearby research programs (e.g.-Gladstone Institute). The intellectual environment is exciting for trainees. Monthly multidisciplinary conferences (e.g.-Brain Club) host speakers who discuss translational science issues that attract both clinicians and bench scientists. These conferences are followed by an opportunity to informally mix with colleagues who have diverse clinical and scientific interests. The R25 has been a crucial linchpin for the development of research skills by our talented young physician-scientists in neurology and neuropathology at UCSF. In the era of sequestration, which has challenged the stability of mid-career and senior neuroscientists, the R25 has become an even more important stable NIH program for ensuring that our most talented early career neuroscientists are well-supported. Our early track record among participants who have completed the program is encouraging. Of four trainees who have completed the program at UCSF, all continue to be engaged in laboratory research. One has received K-award funding, one has applied for K-award funding and received a very favorable score, and the other two plans to apply for K-award funding in the next year. Two have received funding from sources other than NIH (CIRM, Giannini Foundation, and Alzheimer's Disease Research Center Pilot Grant). One is an author on a peer-reviewed papers related to the R25 research program and another has a manuscript under review. Two trainees (one neuropathology and one neurology) had a change of heart and moved to careers in the pharmaceutical industry. While the program is still early in evolution, it is clear that UCS can provide the training time and research environment to foster early research career development for physician-scientists.