Educating Physician-Neuroscientists: The R25 at UCSF

 描述(由申请人提供)：培养医生-神经科学家：加州大学旧金山分校神经病学系在过去5年中一直是加州大学旧金山分校R25项目的机构赞助商，也是此次申请续签的国内部门。神经学和神经病理学都通过这个项目支持了优秀的研究培训候选人。我们很高兴神经外科致力于成为该计划的积极参与者，并在这次续签申请中得到了很好的代表。神经内科在吸引注定要攻读神经病学的优秀医学生方面有着极好的记录。2014年，共有250名美国医学毕业生申请了10个成人神经科职位，我们很幸运地将所有10个职位与排名前11位的申请者进行了匹配。该部门致力于培养下一代国家神经学领导者，我们的神经学住院医师毕业生大量过渡到长期的学术职业生涯，如实验室研究员、临床科学(以患者为基础的)研究员和大学临床教师。位于观澜湾校区的神经学研究大楼(见下面的设施)的启用极大地扩大了研究实习生的机会，并为公共空间的实验室研究项目和附近的研究项目(如Gladstone研究所)之间的合作带来了极大的扩展。对学员来说，智力环境令人兴奋。每月举行的多学科会议(例如，大脑俱乐部)主办演讲者，他们讨论吸引临床医生和实验室科学家的翻译科学问题。在这些会议之后，有机会与具有不同临床和科学兴趣的同事非正式地交往。R25一直是我们才华横溢的年轻内科医生-加州大学旧金山分校神经学和神经病理学科学家-发展研究技能的关键。在自动减支的时代，这对职业生涯中期和高级神经科学家的稳定性构成了挑战，R25已经成为NIH一个更重要的稳定项目，以确保我们最有才华的早期职业神经科学家得到很好的支持。我们在完成该计划的参与者中的早期记录令人鼓舞。在加州大学旧金山分校完成该项目的四名学员中，所有人都继续从事实验室研究。一个已经获得了K奖资助，一个已经申请了K奖资助并获得了非常好的成绩，另外两个计划在明年申请K奖资助。其中两个已从NIH以外的来源获得资金(CIRM、Giannini基金会和阿尔茨海默病研究中心试点赠款)。其中一人是与R25研究项目相关的同行评议论文的作者，另一人的手稿正在审查中。两名实习生(一名神经病理学和一名神经病学)改变了主意，转行从事制药行业的工作。虽然该计划仍处于早期发展阶段，但很明显，UCS可以提供培训时间和研究环境，以促进医生-科学家的早期研究职业发展。

 DESCRIPTION (provided by applicant): Educating Physician-Neuroscientists: The Department of Neurology at UCSF has been the institutional sponsor for the R25 program at UCSF over the past 5 years and is the home department for this application renewal. Both neurology and neuropathology have supported outstanding research training candidates through this program. We are pleased that the Department of Neurosurgery has committed to becoming an active participant in the program and is well-represented in this renewal application. The Department of Neurology has an excellent record for attracting outstanding medical students destined for neurology. Out of 250 applications from US medical graduates for 10 adult neurology positions in 2014, we were fortunate to match all 10 positions to the top eleven applicants on our rank list. The department aspires to train the next generation of national neurology leaders and our neurology residency graduates transition in high numbers to long term academic careers as laboratory investigators, clinical science (patient- based) investigators, and university-based clinician teachers. The opening of the Neurology Research building at the Mission Bay campus (see facilities below) has resulted in greatly expanded opportunities for research trainees and collaboration between laboratory research programs in a common space and with nearby research programs (e.g.-Gladstone Institute). The intellectual environment is exciting for trainees. Monthly multidisciplinary conferences (e.g.-Brain Club) host speakers who discuss translational science issues that attract both clinicians and bench scientists. These conferences are followed by an opportunity to informally mix with colleagues who have diverse clinical and scientific interests. The R25 has been a crucial linchpin for the development of research skills by our talented young physician-scientists in neurology and neuropathology at UCSF. In the era of sequestration, which has challenged the stability of mid-career and senior neuroscientists, the R25 has become an even more important stable NIH program for ensuring that our most talented early career neuroscientists are well-supported. Our early track record among participants who have completed the program is encouraging. Of four trainees who have completed the program at UCSF, all continue to be engaged in laboratory research. One has received K-award funding, one has applied for K-award funding and received a very favorable score, and the other two plans to apply for K-award funding in the next year. Two have received funding from sources other than NIH (CIRM, Giannini Foundation, and Alzheimer's Disease Research Center Pilot Grant). One is an author on a peer-reviewed papers related to the R25 research program and another has a manuscript under review. Two trainees (one neuropathology and one neurology) had a change of heart and moved to careers in the pharmaceutical industry. While the program is still early in evolution, it is clear that UCS can provide the training time and research environment to foster early research career development for physician-scientists.