Integrated Biostatistical Training for CVD Research

项目名称：心血管疾病研究的综合生物统计学培训 项目摘要/摘要 这项申请建议更新一个新的、综合的生物统计学博士前培训计划 专注于培训学员在心血管疾病研究方面的职业生涯。不断攀升的需求 熟练的生物统计学家有能力在这个令人兴奋的时代应对正在进行的和正在出现的挑战 心血管疾病研究需要培训，正式整合深入和持续的经验 在多学科环境中协作，掌握所需的统计学理论基础 有效地应用先进的生物统计技术和研究开发新的 方法，并非常重视沟通和领导能力。该计划将是一项共同努力 北卡罗来纳州立大学(NCSU)统计系、杜克大学 生物统计和生物信息学(B&B)和杜克临床研究所(DCRI)。它利用了 两个部门和一家最大的医学研究机构之间的长期伙伴关系 世界学术研究组织，拥有国际知名的研究人员 心血管疾病及相关研究。这项为期五年的计划将支持五(5)个见习职位 NCSU部门和杜克大学B&B分校第一年和第二年一(1)个职位和第三至第五年两(2)个职位。 NCSU、Duke和DCRI每年将分别提供两个、一个和两个匹配的职位。实习生 每个机构都将严格学习统计理论，包括概率、推论、线性和 其他统计模型、高级概率和高级统计推断；以及统计方法， 包括临床试验设计/分析、纵向数据分析、生存分析和前沿话题， 如与生物医学大数据相关的记录链接、机器学习、并行计算等。他们还将 接受生物学和心血管医学基础方面的培训以及研究 责任和道德；以及广泛的正式和有经验的沟通和领导技能培训。 学员将逐步接触DCRI心血管疾病研究，并向完全合作的方向发展 学徒制，他们被整合为DCRI项目团队的职能成员。通过这件事 学徒制和正规课程和研讨会，学员将发展相当多的工作知识 心血管医学，这将使他们能够立即对心血管疾病做出贡献 在项目完成后进行研究。每个学员将被分配一个跨机构的指导团队 由NCSU和B&B各一名生物统计学家导师和一名主要从属关系的临床医生导师组成 在DCRI，它将合作指导他们完成所有方面。论文研究将涉及 受学员挑战的启发，开发和评估新的统计方法 合作。学员将受益于接触两个机构的不同文化，拓宽 他们的观点以及获得课程、研讨会和其他资源的机会。 好了！

Project Title: Integrated Biostatistical Training for CVD Research PROJECT SUMMARY/ABSTRACT This application proposes renewal of a novel, integrated program for predoctoral training in biostatistics focused on preparing trainees for careers in cardiovascular disease research. The escalating demand for skilled biostatisticians equipped to address ongoing and emerging challenges in this exciting era of cardiovascular disease research calls for training that formally integrates deep and sustained experience in collaboration in a multidisciplinary environment, mastery of the theoretical underpinnings of statistics required for valid application of sophisticated biostatistical techniques and for research on development of new methodology, and strong emphasis on communication and leadership skills. The program will be a joint effort of the Department of Statistics at North Carolina State University (NCSU), the Duke University Department of Biostatistics and Bioinformatics (B&B), and the Duke Clinical Research Institute (DCRI). It capitalizes on the long-standing partnership between the two departments and a medical research institution that is the largest Academic Research Organization in the world, with internationally known researchers at the forefront of cardiovascular disease and related research. The five-year program will support five (5) trainee positions in the NCSU Department and one (1) position in Years 1 and 2 and two (2) in Years 3-5 in Duke B&B. In addition, NCSU, Duke, and DCRI will provide two, one, and two matching positions in each year, respectively. Trainees at each institution will pursue rigorous study of statistical theory, including probability, inference, linear and other statistical models, advanced probability, and advanced statistical inference; and of statistical methods, including clinical trials design/analysis, longitudinal data analysis, survival analysis, and cutting-edge topics, such as record linkage, machine learning, parallel computing relevant to biomedical Big Data. They will also receive training in fundamental aspects of biology and cardiovascular medicine as well as research responsibility and ethics; and extensive formal and experiential training in communication and leadership skills. Trainees will be introduced to DCRI cardiovascular disease research gradually and evolve to full collaborative apprenticeships in which they are integrated as functioning members of DCRI project teams. Through this apprenticeship and formal courses and seminars, trainees will develop considerable working knowledge of cardiovascular medicine that will position them to make immediate contributions to cardiovascular disease research upon completion of the program. Each trainee will be assigned an inter-institutional mentorship team comprising a biostatistician mentor at each of NCSU and B&B and a clinician mentor whose primary affiliation is at DCRI, which will collaborate in guiding them through all aspects. Dissertation research will involve development and evaluation of novel statistical methodology inspired by challenges encountered in trainees' collaborations. Trainees will benefit from exposure to different cultures across both institutions, broadening their perspectives and access to courses, seminars, and other resources. !