Computational Resource and Dissemination Core

这一雄心勃勃的计划项目的总体科学目标是开发创新的统计方法 有助于加速将有效的新疗法成功引入实践的癌症临床试验 计算资源和传播核心(核心C)将执行几项关键职能 实施和传播用于设计和分析癌症的统计方法 在五个研究项目中开展的临床试验。核心的任务将是近距离开发 与项目调查人员协作，高效、健壮的代码实施统计方法，可以 用于评估广泛的模拟研究中的方法，并将方法应用于 由核心B和其他来源汇编的数据。核心还将负责领导和促进， 在与项目调查人员的密切合作下，开发健壮、可靠、用户友好和有良好记录的 适合向参与设计的从业者公开发布的软件应用程序 以及癌症临床试验的分析。Core C将为这些任务采用最佳实践，并提供 传播这些应用程序所需的信息技术和教育基础设施。

The overall scientific goal of this ambitious Program Project is to develop innovative statistical methods for cancer clinical trials that can help to hasten successful introduction of effective new therapies into practice The Computational Resource and Dissemination Core (Core C) will carry out several critical functions related to the implementation and dissemination of the statistical methods for the design and analysis of cancer clinical trials developed in the five research projects. The Core will be tasked with developing, in close collaboration with project investigators, efficient, robust code implementing the statistical methods that can be used for evaluation of the methods in extensive simulation studies and for application of the methods to data compiled by Core B and from other sources. The Core will also be tasked with leading and facilitating, in close collaboration with project investigators, development of robust, reliable, user-friendly, and welldocumented software applications suitable for public dissemination to practitioners involved in the design and analysis of cancer clinical trials. Core C wili adopt best practices for these tasks and provide the necessary information technology and educational infrastructure to disseminate these applications.