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COBRE:Eukaryotic Pathogens Innovation Center (EPIC)

COBRE：真核病原体创新中心（EPIC）

基本信息

批准号：
9261570
负责人：
LESLY A TEMESVARI
金额：
$ 213.47万
依托单位：
CLEMSON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-04-15 至 2021-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9261570
关键词：
Acetates African African Trypanosomiasis Amebic colitis Aneuploidy Area Assistantship Biogenesis Biology Bioterrorism Cardiovascular Diseases Cell Separation Centers of Research Excellence Chagas Disease Communicable Diseases Complement Complex Core Facility Cryptococcus neoformans Detection Development Diagnosis Disease Drug resistance Dysentery Entamoeba histolytica Environment Environmental Risk Factor Equilibrium Equipment Faculty Faculty Recruitment Fatty Acids Fermentation Fluconazole Fostering Funding Future Genomics Glucose Glycosome Goals Government Grant Host Defense Human Image Incidence Infection Interdisciplinary Study Knowledge Leadership Malaria Mass Spectrum Analysis Medical Meningitis Mentors Metabolism Microbial Genetics Modeling Oral health Organelles Parasitic Diseases Parasitic infection Participant Pathogenesis Peer Review Grants Phenotype Pilot Projects Probability Program Research Project Grants Recruitment Activity Research Research Infrastructure Research Personnel Resource Allocation Role Scientist South Carolina Talents Targeted Research Training Trypanosoma Trypanosoma brucei brucei United States National Institutes of Health Universities Variant Virulence base dietary supplements drug discovery genetic evolution hexokinase human disease innovation insight member multidisciplinary neglected tropical diseases oxidant stress pathogen programs public health relevance resistance mechanism senior faculty skills success tissue regeneration transmission process vaccine development vector

项目摘要

DESCRIPTION (provided by applicant): Eukaryotic pathogens are the causative agents of some of the most devastating and intractable diseases of humans, including malaria, amebic dysentery, sleeping sickness, Chagas disease, and meningitis. The global impact of these diseases is immense. It is noteworthy that many of these pathogens are the causative agents of neglected tropical diseases (NTDs) and/or are also classified as bioterrorism agents. Importantly, infections caused by eukaryotic pathogens are increasing in the US due to globalization. The primary goal of this COBRE proposal is to increase the number of NIH-funded scientists in the state of South Carolina by establishing a world-class research center, the Eukaryotic Pathogens Innovation Center (EPIC), at Clemson University (CU). The scientific focus of EPIC will be a multidisciplinary study of important global eukaryotic pathogens. Five projects from target junior investigators will be supported. Their projects are 1) The role of acetate fermentation in Entamoeba histolytica virulence; 2) Glycosome biogenesis in African trypanosomes; 3) Glucose Sensing and Hexokinases in the African Trypanosome; 4) Fatty acid synthesis in Trypanosoma brucei, and 5) Exploring the mechanisms of fluconazole-induced aneuploidy in Cryptococcus neoformans. These investigators will be matched with mentors who are established NIH-funded researchers. The projects will be supported by a well-organized Administrative Core and two state-of-the-art Scientific Cores in Genomics, Imaging and Cell Sorting, and Mass Spectroscopy. The Scientific Cores will also benefit at least two other COBRE-funded centers in the state of South Carolina and other faculty at CU. The center also has a substantial infrastructure base and significant institutional support. For example, CU will recruit three additional investigators to expand activities of this center over the course of the project period. Pledges of graduate assistantships, equipment, and space further exemplify the institutional commitment. This COBRE-funded center will significantly expand research in South Carolina and will facilitate recruitment, training, and retention of a critical mass of investigatos with cross-disciplinary skills in this important research area.