COBRE:Eukaryotic Pathogens Innovation Center (EPIC)

COBRE：真核病原体创新中心（EPIC）

基本信息

批准号：
9261570
负责人：
LESLY A TEMESVARI
金额：
$ 213.47万
依托单位：
CLEMSON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-04-15 至 2021-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9261570
关键词：
Acetates African African Trypanosomiasis Amebic colitis Aneuploidy Area Assistantship Biogenesis Biology Bioterrorism Cardiovascular Diseases Cell Separation Centers of Research Excellence Chagas Disease Communicable Diseases Complement Complex Core Facility Cryptococcus neoformans Detection Development Diagnosis Disease Drug resistance Dysentery Entamoeba histolytica Environment Environmental Risk Factor Equilibrium Equipment Faculty Faculty Recruitment Fatty Acids Fermentation Fluconazole Fostering Funding Future Genomics Glucose Glycosome Goals Government Grant Host Defense Human Image Incidence Infection Interdisciplinary Study Knowledge Leadership Malaria Mass Spectrum Analysis Medical Meningitis Mentors Metabolism Microbial Genetics Modeling Oral health Organelles Parasitic Diseases Parasitic infection Participant Pathogenesis Peer Review Grants Phenotype Pilot Projects Probability Program Research Project Grants Recruitment Activity Research Research Infrastructure Research Personnel Resource Allocation Role Scientist South Carolina Talents Targeted Research Training Trypanosoma Trypanosoma brucei brucei United States National Institutes of Health Universities Variant Virulence base dietary supplements drug discovery genetic evolution hexokinase human disease innovation insight member multidisciplinary neglected tropical diseases oxidant stress pathogen programs public health relevance resistance mechanism senior faculty skills success tissue regeneration transmission process vaccine development vector

项目摘要

DESCRIPTION (provided by applicant): Eukaryotic pathogens are the causative agents of some of the most devastating and intractable diseases of humans, including malaria, amebic dysentery, sleeping sickness, Chagas disease, and meningitis. The global impact of these diseases is immense. It is noteworthy that many of these pathogens are the causative agents of neglected tropical diseases (NTDs) and/or are also classified as bioterrorism agents. Importantly, infections caused by eukaryotic pathogens are increasing in the US due to globalization. The primary goal of this COBRE proposal is to increase the number of NIH-funded scientists in the state of South Carolina by establishing a world-class research center, the Eukaryotic Pathogens Innovation Center (EPIC), at Clemson University (CU). The scientific focus of EPIC will be a multidisciplinary study of important global eukaryotic pathogens. Five projects from target junior investigators will be supported. Their projects are 1) The role of acetate fermentation in Entamoeba histolytica virulence; 2) Glycosome biogenesis in African trypanosomes; 3) Glucose Sensing and Hexokinases in the African Trypanosome; 4) Fatty acid synthesis in Trypanosoma brucei, and 5) Exploring the mechanisms of fluconazole-induced aneuploidy in Cryptococcus neoformans. These investigators will be matched with mentors who are established NIH-funded researchers. The projects will be supported by a well-organized Administrative Core and two state-of-the-art Scientific Cores in Genomics, Imaging and Cell Sorting, and Mass Spectroscopy. The Scientific Cores will also benefit at least two other COBRE-funded centers in the state of South Carolina and other faculty at CU. The center also has a substantial infrastructure base and significant institutional support. For example, CU will recruit three additional investigators to expand activities of this center over the course of the project period. Pledges of graduate assistantships, equipment, and space further exemplify the institutional commitment. This COBRE-funded center will significantly expand research in South Carolina and will facilitate recruitment, training, and retention of a critical mass of investigatos with cross-disciplinary skills in this important research area.

描述（由适用提供）：真核病原体是一些人类最具毁灭性和棘手的疾病的灾难性药物，包括疟疾，阿米巴克疾病，睡眠疾病，chagas病和脑膜炎。这些疾病的全球影响是巨大的。值得注意的是，这些病原体中的许多是被忽视的热带疾病（NTD）和/或也被归类为生物恐怖剂的灾难性药物。重要的是，由于全球化，由真核病原体引起的感染正在增加。这项杂种提案的主要目标是通过在克莱姆森大学（CU）建立世界一流的研究中心，真核病原体创新中心（EPIC）来增加南卡罗来纳州NIH资助的科学家的数量。 EPIC的科学重点将是对重要全球真核病原体的多学科研究。将支持来自目标初级调查人员的五个项目。他们的项目是1）乙酸盐发酵在溶血性病毒中的作用； 2）非洲锥虫中的糖体生物发生； 3）非洲锥虫中的葡萄糖传感和己糖酶； 4）Brucei锥虫瘤中的脂肪酸合成，以及5）探索氟康唑诱导的新甲虫中的非整倍性的机理。这些调查人员将与成立NIH资助的研究人员的导师相匹配。这些项目将由组织良好的行政核心和两个最先进的科学核心支持基因组学，成像和细胞分类以及质谱。科学核心还将受益于南卡罗来纳州和CU的其他教职员工至少两个由毛茸茸资助的中心受益。机构支持。例如，CU将在整个项目期间招募另外三名调查人员来扩大该中心的活动。研究生助理，设备和空间的承诺进一步示例机构承诺。这个由山羊资助的中心将大大扩大南卡罗来纳州的研究，并有助于在这个重要的研究领域招募，培训和保留具有跨学科技能的重要研究人员。