COBRE:Eukaryotic Pathogens Innovation Center (EPIC)

COBRE：真核病原体创新中心（EPIC）

• 批准号: 9261570
• 负责人: LESLY A TEMESVARI
• 金额: $ 213.47万
• 依托单位: CLEMSON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-04-15 至 2021-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9261570
• 关键词: Acetates; African; African Trypanosomiasis; Amebic colitis; Aneuploidy; Area; Assistantship; Biogenesis; Biology; Bioterrorism; Cardiovascular Diseases; Cell Separation; Centers of Research Excellence; Chagas Disease; Communicable Diseases; Complement; Complex; Core Facility; Cryptococcus neoformans; Detection; Development; Diagnosis; Disease; Drug resistance; Dysentery; Entamoeba histolytica; Environment; Environmental Risk Factor; Equilibrium; Equipment; Faculty; Faculty Recruitment; Fatty Acids; Fermentation; Fluconazole; Fostering; Funding; Future; Genomics; Glucose; Glycosome; Goals; Government; Grant; Host Defense; Human; Image; Incidence; Infection; Interdisciplinary Study; Knowledge; Leadership; Malaria; Mass Spectrum Analysis; Medical; Meningitis; Mentors; Metabolism; Microbial Genetics; Modeling; Oral health; Organelles; Parasitic Diseases; Parasitic infection; Participant; Pathogenesis; Peer Review Grants; Phenotype; Pilot Projects; Probability; Program Research Project Grants; Recruitment Activity; Research; Research Infrastructure; Research Personnel; Resource Allocation; Role; Scientist; South Carolina; Talents; Targeted Research; Training; Trypanosoma; Trypanosoma brucei brucei; United States National Institutes of Health; Universities; Variant; Virulence; base; dietary supplements; drug discovery; genetic evolution; hexokinase; human disease; innovation; insight; member; multidisciplinary; neglected tropical diseases; oxidant stress; pathogen; programs; public health relevance; resistance mechanism; senior faculty; skills; success; tissue regeneration; transmission process; vaccine development; vector

 DESCRIPTION (provided by applicant): Eukaryotic pathogens are the causative agents of some of the most devastating and intractable diseases of humans, including malaria, amebic dysentery, sleeping sickness, Chagas disease, and meningitis. The global impact of these diseases is immense. It is noteworthy that many of these pathogens are the causative agents of neglected tropical diseases (NTDs) and/or are also classified as bioterrorism agents. Importantly, infections caused by eukaryotic pathogens are increasing in the US due to globalization. The primary goal of this COBRE proposal is to increase the number of NIH-funded scientists in the state of South Carolina by establishing a world-class research center, the Eukaryotic Pathogens Innovation Center (EPIC), at Clemson University (CU). The scientific focus of EPIC will be a multidisciplinary study of important global eukaryotic pathogens. Five projects from target junior investigators will be supported. Their projects are 1) The role of acetate fermentation in Entamoeba histolytica virulence; 2) Glycosome biogenesis in African trypanosomes; 3) Glucose Sensing and Hexokinases in the African Trypanosome; 4) Fatty acid synthesis in Trypanosoma brucei, and 5) Exploring the mechanisms of fluconazole-induced aneuploidy in Cryptococcus neoformans. These investigators will be matched with mentors who are established NIH-funded researchers. The projects will be supported by a well-organized Administrative Core and two state-of-the-art Scientific Cores in Genomics, Imaging and Cell Sorting, and Mass Spectroscopy. The Scientific Cores will also benefit at least two other COBRE-funded centers in the state of South Carolina and other faculty at CU. The center also has a substantial infrastructure base and significant institutional support. For example, CU will recruit three additional investigators to expand activities of this center over the course of the project period. Pledges of graduate assistantships, equipment, and space further exemplify the institutional commitment. This COBRE-funded center will significantly expand research in South Carolina and will facilitate recruitment, training, and retention of a critical mass of investigatos with cross-disciplinary skills in this important research area.

 描述（由申请人提供）：真核病原体是人类一些最具破坏性和棘手疾病的病原体，包括疟疾、阿米巴痢疾、昏睡病、查加斯病和脑膜炎。这些疾病的全球影响是巨大的。值得注意的是，许多这些病原体是被忽视的热带病（NTD）的病原体和/或也被归类为生物恐怖分子。重要的是，由于全球化，真核病原体引起的感染在美国正在增加。 COBRE 提案的主要目标是通过在克莱姆森大学 (CU) 建立世界一流的研究中心，即真核病原体创新中心 (EPIC)，增加南卡罗来纳州 NIH 资助的科学家数量。 EPIC 的科学重点将是对全球重要的真核病原体进行多学科研究。来自目标初级研究人员的五个项目将得到支持。他们的项目是 1) 醋酸发酵在溶组织内阿米巴毒力中的作用； 2）非洲锥虫中的糖体生物发生； 3）非洲锥虫中的葡萄糖传感和己糖激酶； 4) 布氏锥虫中的脂肪酸合成，以及 5) 探索氟康唑诱导的新型隐球菌非整倍体的机制。这些研究人员将与由 NIH 资助的研究人员导师相匹配。这些项目将得到组织良好的行政核心和两个最先进的基因组学、成像和细胞分选以及质谱科学核心的支持。科学核心还将惠及南卡罗来纳州至少另外两个由 COBRE 资助的中心以及 CU 的其他教员。该中心还拥有雄厚的基础设施基础和重要的机构支持。例如，CU 将招募三名额外的研究人员，以在项目期间扩大该中心的活动。研究生助学金、设备和空间的承诺进一步体现了机构的承诺。该 COBRE 资助的中心将显着扩大南卡罗来纳州的研究范围，并将促进在这一重要研究领域招募、培训和留住大量具有跨学科技能的研究人员。