课题基金 / 基金详情

COBRE:Eukaryotic Pathogens Innovation Center (EPIC)

COBRE:Eukaryotic Pathogens Innovation Center (EPIC)
COBRE:真核病原体创新中心(EPIC)
批准号:
9900800
负责人:
LESLY A TEMESVARI
金额:
$200.61万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2016
资助国家:
美国
项目状态:
已结题
起止时间:
2016-04-15 至 2022-07-14

项目摘要

项目成果

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中文摘要
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英文摘要
 DESCRIPTION (provided by applicant): Eukaryotic pathogens are the causative agents of some of the most devastating and intractable diseases of humans, including malaria, amebic dysentery, sleeping sickness, Chagas disease, and meningitis. The global impact of these diseases is immense. It is noteworthy that many of these pathogens are the causative agents of neglected tropical diseases (NTDs) and/or are also classified as bioterrorism agents. Importantly, infections caused by eukaryotic pathogens are increasing in the US due to globalization. The primary goal of this COBRE proposal is to increase the number of NIH-funded scientists in the state of South Carolina by establishing a world-class research center, the Eukaryotic Pathogens Innovation Center (EPIC), at Clemson University (CU). The scientific focus of EPIC will be a multidisciplinary study of important global eukaryotic pathogens. Five projects from target junior investigators will be supported. Their projects are 1) The role of acetate fermentation in Entamoeba histolytica virulence; 2) Glycosome biogenesis in African trypanosomes; 3) Glucose Sensing and Hexokinases in the African Trypanosome; 4) Fatty acid synthesis in Trypanosoma brucei, and 5) Exploring the mechanisms of fluconazole-induced aneuploidy in Cryptococcus neoformans. These investigators will be matched with mentors who are established NIH-funded researchers. The projects will be supported by a well-organized Administrative Core and two state-of-the-art Scientific Cores in Genomics, Imaging and Cell Sorting, and Mass Spectroscopy. The Scientific Cores will also benefit at least two other COBRE-funded centers in the state of South Carolina and other faculty at CU. The center also has a substantial infrastructure base and significant institutional support. For example, CU will recruit three additional investigators to expand activities of this center over the course of the project period. Pledges of graduate assistantships, equipment, and space further exemplify the institutional commitment. This COBRE-funded center will significantly expand research in South Carolina and will facilitate recruitment, training, and retention of a critical mass of investigatos with cross-disciplinary skills in this important research area.
期刊论文(68)
专著(0)
科研奖励(0)
会议论文
A targeted delivery strategy for the development of potent trypanocides.
开发强效锥虫杀剂的靶向递送策略。
DOI: 10.1039/c7cc03378h
发表时间: 2017
期刊: Chemical communications (Cambridge, England)
影响因子: --
作者: [Gordhan,HeerenM, Milanes,JillianE, Qiu,Yijian, Golden,JenniferE, Christensen,KennethA, Morris,JamesC, Whitehead,DanielC]
通讯作者: Whitehead,DanielC
The Tiger Rattlesnake genome reveals a complex genotype underlying a simple venom phenotype
虎响尾蛇基因组揭示了简单毒液表型背后的复杂基因型
DOI: 10.1073/pnas.2014634118
发表时间: 2021
期刊: Proceedings of the National Academy of Sciences
影响因子: --
作者: [Margres, Mark J., Rautsaw, Rhett M., Strickland, Jason L., Mason, Andrew J., Schramer, Tristan D., Hofmann, Erich P., Stiers, Erin, Ellsworth, Schyler A., Nystrom, Gunnar S., Hogan, Michael P.]
通讯作者: Hogan, Michael P.
DOI: 10.1111/nph.18655
发表时间: 2023-03
期刊: NEW PHYTOLOGIST
影响因子: 9.4
作者: [Cai, Lichun, Comont, David, MacGregor, Dana, Lowe, Claudia, Beffa, Roland, Neve, Paul, Saski, Christopher]
通讯作者: Saski, Christopher
DOI: 10.1002/elps.201700428
发表时间: 2018-09
期刊: Electrophoresis
影响因子: 2.9
作者: [Li D, Zielinski J, Kozubowski L, Xuan X]
通讯作者: Xuan X
46
    COBRE:Eukaryotic Pathogens Innovation Center (EPIC)
    • 批准号:
      9261570
    • 项目类别:
    • 资助金额:
      $213.47万
    • 财政年份:
      2016
    • 负责人:
      LESLY A TEMESVARI
    • 依托单位:
    Stress Induced Control of Protein Translation in Entamoeba Histolytica
    • 批准号:
      8664552
    • 项目类别:
    • 资助金额:
      $7.36万
    • 财政年份:
      2014
    • 负责人:
      LESLY A TEMESVARI
    • 依托单位:
    A forward genetics screen for genes regulating phagocytosis and signaling in Enta
    • 批准号:
      7876802
    • 项目类别:
    • 资助金额:
      $18.56万
    • 财政年份:
      2009
    • 负责人:
      LESLY A TEMESVARI
    • 依托单位:
    A forward genetics screen for genes regulating phagocytosis and signaling in Enta
    • 批准号:
      7573223
    • 项目类别:
    • 资助金额:
      $21.25万
    • 财政年份:
      2009
    • 负责人:
      LESLY A TEMESVARI
    • 依托单位:
    海外基金