Dynamics of episodic memory and event segmentation

 描述（由申请人提供）：情景记忆被定义为外显记忆的类型，其中事件的各个方面被整合在一起并与它们发生的上下文相关联。情节记忆的缺陷可能对日常功能造成破坏，并且是许多神经系统疾病中普遍存在的症状。有趣的是，情景记忆功能困难的患者也可能表现出难以将连续信息分割成有意义的事件。最近在健康成年人中已经表明，情景记忆表现和事件分割能力不是独立的测量。一个正在进行的表示上下文是至关重要的适当识别的新奇和事件分割已被证明会影响记忆组织。此外，事件分割可以诱导自上而下的过程来调节新奇的反应和期望。这个提议的目的是了解事件分割及其与情景记忆的关系。这将有助于了解健康成年人这些过程之间的依赖关系，也可能对那些表现出这些功能缺陷的神经系统疾病患者产生影响。我们将研究这些过程中，使用皮层电图，功能性磁共振成像和行为的措施，由预测的情景记忆的计算神经网络模型的动机。我们将描述事件结构和分割如何影响大脑活动，而信息被呈现和随后的记忆检索，以及它们如何影响哪些信息被记住，以及如何在记忆中组织信息。

 DESCRIPTION (provided by applicant): Episodic memory is defined as the type of explicit memory in which aspects of an event are integrated together and associated with the context in which they occur. Deficiency in episodic memory can be devastating to everyday functions, and is a symptom ubiquitous across many neurological disorders. Interestingly, patients with difficulty in episodic memory function may also exhibit difficulty segmenting continuous information into meaningful events. Recently it has been shown in healthy adults that episodic memory performance and event segmentation ability are not independent measures. An ongoing representation of context is critical for appropriate recognition of novelty and event segmentation has been shown to influence memory organization. In addition, event segmentation can induce top-down processes to modulate novelty responses and expectations. The purpose of this proposal is to understand event segmentation and its relationship to episodic memory. This will help to inform the dependencies between these processes in healthy adults and may also have implications for patients with neurological disorders who exhibit deficiencies in these functions. We will examine these processes using electrocorticography, functional magnetic resonance imaging and behavioral measures, motivated by predictions of a computational neural network model of episodic memory. We will characterize how event structure and segmentation impact brain activity while information is being presented and during subsequent memory retrieval, as well as how they impact which information is remembered and how that information is organized in memory.