Dopamine as a therapeutic agent in stomach cancer

多巴胺作为胃癌的治疗剂

• 批准号: 9231439
• 负责人: Sujit Basu
• 金额: $ 31.96万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-03-01 至 2020-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9231439
• 关键词: 8-hydroxy-2' -deoxyguanosine; Address; Adult; Agonist; Animals; Cancer Etiology; Cells; Cessation of life; Clinical; Cyclic AMP-Dependent Protein Kinases; Cytoprotection; DNA Damage; DNA Markers; Diagnosis; Disease; Disease Progression; Dopamine; Epithelial Cells; Experimental Designs; Gastric Tissue; Goals; Growth; Helicobacter felis; Human; Incidence; Knockout Mice; Knowledge; Lesion; Measures; Mediating; Mus; Oxidative Stress; Pathway interactions; Patients; Play; Pre-Clinical Model; Prevention; Process; Production; Reactive Oxygen Species; Receptor Signaling; Reporting; Research; Research Design; Role; Signal Pathway; Specificity; Stomach; System; Therapeutic Agents; Tissues; Treatment Efficacy; Wild Type Mouse; cancer cell; cancer therapy; cancer type; carcinogenesis; combat; dopamine D5 receptor; effective therapy; efficacy testing; in vivo; indexing; malignant stomach neoplasm; neutrophil; novel; novel therapeutics; prevent; promoter; public health relevance; receptor; receptor function; time interval; treatment effect; tumorigenesis

DESCRIPTION (provided by applicant): Gastric cancer is one of the leading causes of cancer-related deaths in the world. Despite major research and clinical efforts, the results for th treatment of gastric cancer in general have been poor and thus newer and effective therapies are necessary to combat this disease. With reports indicating that substantial amount of DA is produced in normal stomach tissues and DA mediates cytoprotection of gastric epithelial cells by acting through its receptors present in these cells, we therefore postulated that this non-neuronal dopaminergic system in the stomach might also play an important role in gastric tumorigenesis. Thus Aim 1 will investigate the role of non-neuronal stomach dopaminergic system in gastric tumorigenesis, Aim 2 will elucidate the signaling pathway through which dopamine D5 receptors regulate reactive oxygen species in stomach and Aim 3 will determine the therapeutic efficacies of DA D5 receptor agonists in gastric tumorigenesis. The knowledge generated from this study will help to develop newer and effective therapies for this disease, which, as of yet, has no significant treatment.

描述(申请人提供)：胃癌是世界上与癌症相关的死亡的主要原因之一。尽管进行了大量的研究和临床工作，但总的来说，胃癌的治疗效果很差，因此需要更新有效的治疗方法来对抗这种疾病。有报道表明，正常胃组织中存在大量的DA，DA通过其受体介导胃上皮细胞的细胞保护作用，因此我们推测胃中的这种非神经性多巴胺能系统在胃肿瘤的发生中也可能起重要作用。因此，目标1将研究非神经性胃多巴胺能系统在胃肿瘤发生中的作用，目标2将阐明多巴胺D5受体调节胃内活性氧的信号通路，目标3将确定多巴胺D5受体激动剂在胃肿瘤发生中的治疗效果。这项研究产生的知识将有助于开发针对这种疾病的更新和有效的治疗方法，到目前为止，这种疾病还没有明显的治疗方法。