Dopamine as a therapeutic agent in stomach cancer

描述（由申请人提供）：胃癌是世界上癌症相关死亡的主要原因之一。尽管进行了大量的研究和临床努力，但总的来说，胃癌的治疗效果很差，因此需要更新和有效的治疗方法来对抗这种疾病。有报道表明，正常胃组织中产生大量的DA，并且DA通过存在于胃上皮细胞中的受体介导胃上皮细胞的细胞保护，因此我们假设胃中的这种非神经元多巴胺能系统也可能在胃肿瘤发生中发挥重要作用。因此，Aim 1将研究非神经元胃多巴胺能系统在胃肿瘤发生中的作用，Aim 2将阐明多巴胺D5受体调节胃活性氧的信号通路，Aim 3将确定DA D5受体激动剂在胃肿瘤发生中的治疗效果。从这项研究中产生的知识将有助于开发更新和有效的治疗这种疾病的方法，到目前为止，这种疾病还没有明显的治疗方法。

DESCRIPTION (provided by applicant): Gastric cancer is one of the leading causes of cancer-related deaths in the world. Despite major research and clinical efforts, the results for th treatment of gastric cancer in general have been poor and thus newer and effective therapies are necessary to combat this disease. With reports indicating that substantial amount of DA is produced in normal stomach tissues and DA mediates cytoprotection of gastric epithelial cells by acting through its receptors present in these cells, we therefore postulated that this non-neuronal dopaminergic system in the stomach might also play an important role in gastric tumorigenesis. Thus Aim 1 will investigate the role of non-neuronal stomach dopaminergic system in gastric tumorigenesis, Aim 2 will elucidate the signaling pathway through which dopamine D5 receptors regulate reactive oxygen species in stomach and Aim 3 will determine the therapeutic efficacies of DA D5 receptor agonists in gastric tumorigenesis. The knowledge generated from this study will help to develop newer and effective therapies for this disease, which, as of yet, has no significant treatment.