Dopamine as a therapeutic agent in stomach cancer

多巴胺作为胃癌的治疗剂

• 批准号: 9013455
• 负责人: Sujit Basu
• 金额: $ 31.96万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-03-01 至 2018-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9013455
• 关键词: 8-hydroxy-2' -deoxyguanosine; Address; Adult; Agonist; Animals; Cancer Etiology; Cells; Cessation of life; Clinical; Cyclic AMP-Dependent Protein Kinases; Cytoprotection; DNA Damage; Disease; Disease Progression; Dopamine; Epithelial Cells; Experimental Designs; Gastric Tissue; Goals; Growth; Health; Helicobacter felis; Human; Incidence; Knockout Mice; Knowledge; Lead; Lesion; Malignant Neoplasms; Measures; Mediating; Mus; Oxidative Stress; Pathway interactions; Patients; Play; Pre-Clinical Model; Prevention; Process; Production; Reactive Oxygen Species; Receptor Signaling; Reporting; Research; Research Design; Role; Second Primary Cancers; Signal Pathway; Specificity; Staging; Stomach; System; Therapeutic Agents; Tissues; Treatment Efficacy; Wild Type Mouse; cancer cell; cancer type; carcinogenesis; combat; disease diagnosis; dopamine D5 receptor; effective therapy; efficacy testing; in vivo; indexing; malignant stomach neoplasm; neutrophil; novel; novel therapeutics; prevent; promoter; receptor; receptor function; time interval; treatment effect; tumorigenesis

DESCRIPTION (provided by applicant): Gastric cancer is one of the leading causes of cancer-related deaths in the world. Despite major research and clinical efforts, the results for th treatment of gastric cancer in general have been poor and thus newer and effective therapies are necessary to combat this disease. With reports indicating that substantial amount of DA is produced in normal stomach tissues and DA mediates cytoprotection of gastric epithelial cells by acting through its receptors present in these cells, we therefore postulated that this non-neuronal dopaminergic system in the stomach might also play an important role in gastric tumorigenesis. Thus Aim 1 will investigate the role of non-neuronal stomach dopaminergic system in gastric tumorigenesis, Aim 2 will elucidate the signaling pathway through which dopamine D5 receptors regulate reactive oxygen species in stomach and Aim 3 will determine the therapeutic efficacies of DA D5 receptor agonists in gastric tumorigenesis. The knowledge generated from this study will help to develop newer and effective therapies for this disease, which, as of yet, has no significant treatment.

描述（由申请人提供）：胃癌是世界上癌症相关死亡的主要原因之一。尽管有重大的研究和临床努力，但胃癌的治疗结果总体上很差，因此需要更新和有效的治疗方法来对抗这种疾病。有报道表明正常胃组织中产生大量的DA，并且DA通过其存在于胃上皮细胞中的受体介导胃上皮细胞的细胞保护，因此我们推测胃中的这种非神经元多巴胺能系统也可能在胃肿瘤发生中起重要作用。因此，本研究的目的1是探讨非神经元型胃多巴胺能系统在胃癌发生中的作用，目的2是阐明多巴胺D5受体调节胃内活性氧的信号通路，目的3是确定多巴胺D5受体激动剂在胃癌发生中的治疗效果。从这项研究中产生的知识将有助于为这种疾病开发更新和有效的治疗方法，到目前为止，这种疾病还没有显著的治疗方法。