Neural and Pharmacological Mechanisms of Abused Drugs

滥用药物的神经和药理学机制

• 批准号: 9404132
• 负责人: Kathryn A. Cunningham
• 金额: --
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-12-01 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9404132
• 关键词: Pharmacology; drug of abuse; relating to nervous system

DESCRIPTION (provided by applicant): Substance abuse and addictive disorders constitute a major, high-impact health problem. This competitive renewal of the training grant Neural and Pharmacological Mechanisms of Abused Drugs (T32DA07287) at the University of Texas Medical Branch (UTMB) proposes to address the large gap between the problem of addiction and efficacious solutions by mentoring the next generation of scientists prepared and committed to the search for answers. The overarching goal of the Training Program is to provide nascent scientists with the knowledge base, technical expertise and professional skills needed to advance knowledge in the addictions and to move these advances toward new therapeutics. The 22 faculty mentors/co-mentors have a wealth of training and career development successes, extensive collaborative networks and expertise in translational addiction research conducted with modern technologies. Our objectives are to provide exemplary training in translational research in the neural bases for drug abuse and addiction, drug discovery and medications development, and the medical consequences of drug abuse and addiction. Strategies to achieve these objectives include providing well-funded, state-of-the-art research opportunities and facilities, effective mentoring and monitoring plans, challenging curricula and supportive interactive programs (e.g., short-term clinical rotations, journal clubs, workgroups, seminars), and first-rate program activities that develop the professional skills needed for advancement towards an independent career. The culmination of our efforts is the success of our trainees as complete, contemporary scientists equipped with the tools to advance the mechanistic understanding of addiction and move these advances toward new therapeutic approaches to its treatment.

描述(由申请人提供)：药物滥用和成瘾障碍构成了一个严重的、高影响的健康问题。德克萨斯大学医学部(UTMB)对滥用药物的神经和药理机制(T32DA07287)进行了竞争性更新，建议通过指导准备并致力于寻找答案的下一代科学家来解决成瘾问题和有效解决方案之间的巨大差距。该培训计划的总体目标是为初出茅庐的科学家提供所需的知识库、技术专长和专业技能，以促进成瘾方面的知识，并将这些进展推向新的疗法。22名教师导师/联合导师拥有丰富的培训和职业发展成功经验，广泛的合作网络，以及利用现代技术进行翻译成瘾研究的专业知识。我们的目标是在药物滥用和成瘾的神经基础、药物发现和药物开发以及药物滥用和成瘾的医学后果方面提供模范的翻译研究培训。实现这些目标的战略包括提供资金充足的、最先进的研究机会和设施、有效的指导和监督计划、具有挑战性的课程和支持性互动计划(例如，短期临床轮换、期刊俱乐部、工作组、研讨会)，以及发展向独立职业发展所需的专业技能的一流计划活动。我们努力的顶峰是我们的受训者的成功，因为他们是完整的、当代的科学家，他们配备了工具来推进对成瘾的机械性理解，并将这些进展推向治疗成瘾的新的治疗方法。