Administrative Core

核心A-核心摘要： 本申请构成继续设立热带医学研究中心的请求 该奖项于2007年和2012年被授予印度瓦拉纳西的巴纳拉斯印度大学。 参与研究的科学家组成了一个多国合作的科学家网络 印度比哈尔邦致命疾病内脏利什曼病的关键方面。这一地区有 印度内脏利什曼病的流行率最高，也是印度最高的 全球内脏利什曼病。更新后的计划将建立在坚实的基础上 在第一个TMRC计划中设立，包括从比哈尔邦进入111,999名受试者 一项重大的流行病学调查。在理解这一问题上取得的重大进展 内脏利什曼病的流行病学、遗传和免疫风险形成了假设 这一更新的应用程序就建立在它的基础上。该计划将包括一个科学核心，一个 健康人口监测系统。提出了三个项目：(1)人 消除性病倡议背景下的流行病学，(2)媒介生物学研究，(3) 人VL的免疫调节作用。该项目将在巴纳拉斯印度大学进行协调， 通过行政核心和数据管理和生物统计核心的努力。 该计划的具体目标是： 1.提供一个科学核心、三个研究项目的行政协调 以及TMRC计划的数据管理和生物统计核心。这将包括 与印度国内外机构的合作调查人员进行沟通， 与NIH人员进行沟通，并保证符合NIH的要求。 2.在Muzaffarpur的KAMRC的Bhu提供财务会计和财务监督， 比利时热带医学研究所，QIMR Berghofer医学研究所， 澳大利亚赫斯顿大学和美国爱荷华大学。这将包括分配资金， 支付工资和全面核算费用。 3.负责项目的日常管理工作。这将涉及购买和 分发设备和研究用品，管理人员，协调 出版物，并就具体项目安排调查人员之间的交流。 4.协调会议和培训活动。主要活动是(A)年度TMRC 在印度瓦拉纳西举行的会议，参加会议的TMRC科学家和 来自Bhu和Muzaffarpur的管理员，以及来自其他国家的合作调查人员 印度、美国、澳大利亚和比利时的大学；(B)印度人的旅行和住房 调查人员参加科学会议、短期课程或短期培训 在合作大学的实验室中的经验。

Core A - Core Summary: This application constitutes a request for continuation of a Tropical Medicine Research Center that was awarded to Banaras Hindu University in Varanasi, India in 2007 and 2012. Participating investigators form a multi-national network of collaborating scientists studying critical aspects of the fatal disease, visceral leishmaniasis, in Bihar State, India. This region has the highest endemic rate of visceral leishmaniasis in India, and one of the highest rates of visceral leishmaniasis worldwide. The renewed program will build on the substantial foundation set up in the first TMRC program, including entry of 111,999 subjects from the state of Bihar into a substantial epidemiological survey. The considerable progress made in understanding the epidemiologic, genetic and immune risks for visceral leishmaniasis have formed the hypotheses upon which this renewed application is built. The program will include one scientific core, a Health Demographic Surveillance System. Three projects are proposed: (1) Human epidemiology in the context of the VL elimination initiative, (2) Vector Biological Studies, (3) Immune regulation in human VL. The program will be coordinated at Banaras Hindu University, through the efforts of the Administrative Core and the Data Management and Biostatistics Core. Specific aims of the program are: 1. To provide administrative coordination of the one scientific core, the three research projects and the Data Management & Biostatistics core of the TMRC program. This will include communication with collaborating investigators at institutions within and outside of India, communication with NIH personnel, and assurance of compliance with NIH requirements. 2. To provide financial accounting and oversight of finances at BHU, KAMRC in Muzaffarpur, Institute of Tropical Medicine, Belgium, QIMR Berghofer Medical Research Institute, Herston, Australia and the University of Iowa, USA. This will include distribution of funds, payment of salaries and overall accounting of expenses. 3. To perform the day to day management of the projects. This will involve purchase and distribution of equipment and research supplies, management of personnel, coordination of publications, and arranging communication between investigators on specific projects. 4. To coordinate meetings and training activities. Key activities are (A) the annual TMRC meeting in Varanasi, India, which is attended by participating TMRC scientists and administrators from BHU and Muzaffarpur, and by collaborating investigators from other universities in India, the USA, Australia and Belgium; (B) travel and housing for Indian investigators to participate in scientific meetings, short courses, or short term training experiences in labs at collaborating universities.