Testing the Effects of Anthrax Immune Globulin (AIG) in a Canine Model of B. anthracis Toxin Associated Shock

测试炭疽免疫球蛋白 (AIG) 在炭疽杆菌毒素相关休克犬模型中的作用

• 批准号: 9549446
• 负责人: Peter Eichacker
• 金额: --
• 依托单位: CLINICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9549446
• 关键词: American; Anthrax disease; Anthrax immune globulin; Antibodies; Antigens; Bacillus anthracis; Canis familiaris; Chest; Clinical; Data; Disease Outbreaks; Edema; Effectiveness; Europe; Evaluation; Goals; Hypotension; Infection; Injecting drug user; Intensive Care; International; Liquid substance; Manuscripts; Medicine; Modeling; Pathogenesis; Pathogenicity; Patients; Preparation; Resistance; Risk; Shock; Societies; Soft Tissue Infections; Testing; Toxin; Vasoconstrictor Agents; hemodynamics; improved; insight; outcome forecast; symposium; tool; weapons; work-study

We previously developed an ICU supported canine model of B. anthracis toxin shock, which has provided essential insights into the pathogenic effects of LT and ET. Using this model we then demonstrated that during LT and ET challenges alone or together, while the benefit with standard hemodynamic was limited, Raxibacumab provided substantial benefit, reducing fluid and vasopressor needs and improving survival even if administered after the onset of hypotension. The goal of the present study is to determine whether AIG also augments standards hemodynamic support during LT and ET challenge together in this canine model. Studies have been completed examining the effects of AIG in this canine model and a manuscript has been submitted an is presently under its first revision for Intensive Care Medicine Experimental. Work from this study was presented at the 2015 International Conference of the American Thoracic Society.

我们之前开发了一种 ICU 支持的犬炭疽杆菌毒素休克模型，该模型为了解 LT 和 ET 的致病作用提供了重要的见解。然后，我们使用该模型证明，在单独或同时进行 LT 和 ET 挑战期间，虽然标准血流动力学的益处有限，但 Raxibacumab 提供了显着的益处，减少了液体和升压药的需求，并提高了生存率，即使在低血压发作后给药也是如此。本研究的目的是确定 AIG 是否也在此犬模型中同时增强 LT 和 ET 挑战期间的标准血流动力学支持。 检验 AIG 在此犬模型中的影响的研究已经完成，手稿已提交，目前正在接受重症监护医学实验的第一次修订。 这项研究的成果已在 2015 年美国胸科学会国际会议上发表。