Testing the Effects of Anthrax Immune Globulin (AIG) in a Canine Model of B. anthracis Toxin Associated Shock

我们以前开发了一个ICU支持的B犬模型。炭疽毒素休克，这提供了必要的见解的致病作用LT和ET。然后使用该模型，我们证明了在LT和ET单独或一起挑战期间，虽然标准血流动力学的益处有限，但即使在低血压发作后给药，Raxibacumab也提供了实质性益处，减少了液体和血管加压药的需求并改善了生存率。本研究的目的是确定AIG是否也增加了标准的血流动力学支持LT和ET挑战在这个犬模型。 研究已经完成，检查AIG在这种犬模型中的影响，并且已经提交了一份手稿，目前正在为重症监护医学实验进行第一次修订。 这项研究的成果在2015年美国胸科学会国际会议上发表。

We previously developed an ICU supported canine model of B. anthracis toxin shock, which has provided essential insights into the pathogenic effects of LT and ET. Using this model we then demonstrated that during LT and ET challenges alone or together, while the benefit with standard hemodynamic was limited, Raxibacumab provided substantial benefit, reducing fluid and vasopressor needs and improving survival even if administered after the onset of hypotension. The goal of the present study is to determine whether AIG also augments standards hemodynamic support during LT and ET challenge together in this canine model. Studies have been completed examining the effects of AIG in this canine model and a manuscript has been submitted an is presently under its first revision for Intensive Care Medicine Experimental. Work from this study was presented at the 2015 International Conference of the American Thoracic Society.