Early Phase Clinical Research Support (Core 019)

CORE-019：早期临床研究支持(EPCRS) 项目摘要/摘要 机构支持临床癌症研究的一个主要领域是研究人员发起的试验。新时代的到来 OSUCCC的新调查人员，对翻译研究的更多关注以及 资助临床试验需要有一种资助研究人员发起的研究的机制 新的代理商和/或新的设计。对创新性第一阶段试验和试点研究的支持以前是 得到CCSG授权的特定议定书研究支持机制的支持。随着最近的变化 在CCSG指南中，采用了早期临床研究支持(EPCRS)机制 自2013年底以来，作为一种刺激开展早期阶段、由调查员发起的研究的手段。这个 EPCRS过程由临床研究(ADCR)副主任威廉·卡森博士监督。 调查人员通过OSUCCC的官方通信被告知这一支持机制 政府和疾病特异性研究小组(DSRG)的领导人。有一份正式的申请 每季度进行一次的过程。提案由ADCR主席William博士主持的一个小组进行审查 卡森。成功的申请者将以研究护士或数据的形式获得CCSG支持 来自CCC的管理协助支持临床试验办公室(CTO)。平均有1-3项研究 每个季度都被批准提供支持。在当前的供资周期中，共进行了13项研究 在EPCRS的支持下，去年共收治了175名患者。此外，对EPCRS来说， OSUCCC有一个正式的同行评审机制，称为校内研究计划(IRP)，以引导 从我们一年一度的自行车筹款活动佩洛托尼亚的发展基金到研究旁边的板凳。

CORE-019: EARLY PHASE CLINICAL RESEARCH SUPPORT (EPCRS) PROJECT SUMMARY / ABSTRACT A major area of institutional support for clinical cancer research is for investigator-initiated trials. The arrival of new investigators into the OSUCCC, the increased attention paid to translational research and changes in the funding landscape of clinical trials requires that there be a mechanism for funding investigator initiated studies of novel agents and/or novel design. The support of innovative Phase I trials and pilot studies was previously supported by the CCSG-mandated Protocol Specific Research Support mechanism. With the recent changes in the CCSG guidelines, the Early Phase Clinical Research Support (EPCRS) mechanism has been employed since late 2013 as a means of stimulating the conduct of early phase, investigator-initiated studies. The EPCRS process is overseen by Dr. William Carson, the Associate Director for Clinical Research (ADCR). Investigators are informed of this OSUCCC support mechanism via official communications from OSUCCC administration and the Disease Specific Research Group (DSRG) leaders. There is a formal application process which is conducted quarterly. Proposals are reviewed by a panel, chaired by the ADCR, Dr. William Carson. Successful applications are selected for CCSG support in the form of research nurse or data management assistance from the CCC supported Clinical Trials Office (CTO). On average 1-3 studies have been approved for support each quarter. In the current funding cycle, a total of 13 studies have been supported by the EPCRS and have accrued a total of 175 patients in the last year. In addition, to EPCRS, the OSUCCC has a formal, peer-reviewed mechanism, called the Intramural Research Program (IRP), to channel developmental funds from Pelotonia, our annual bicycle fundraising event, into bench to beside research.