Genomic analysis of Fungal Pathogenesis
真菌发病机制的基因组分析
基本信息
- 批准号:9248251
- 负责人:
- 金额:$ 50.08万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:
- 资助国家:美国
- 起止时间:至
- 项目状态:未结题
- 来源:
- 关键词:Animal ModelAntifungal AgentsAspergillosisAspergillusAspergillus fumigatusBiologicalBiological AssayCandidaCandida albicansCandidiasisCellsCollectionCommunicable DiseasesCommunitiesComplexDataDevelopmentDiseaseDisease OutcomeElementsFundingGene ExpressionGene Expression RegulationGenerationsGenesGenetic TranscriptionGenomeGenomicsGoalsGrowthHomologous GeneImmune responseImmune systemImmunocompromised HostIndividualInfectionMammalian CellMammalsMetabolic PathwayMicroRNAsMicrobeMucoralesMucormycosisMycosesNatureNorth AmericaOrganismOutcomePathogenesisPathogenicityPhylogenetic AnalysisTechnologyTestingTissuesTranscriptUntranslated RNAWorkcombatcomparativedeep sequencingfallsfollow-upfungal geneticsfungusgene functiongenetic analysisgenetic elementgenome analysisgenome sequencinghuman diseasein vivointerestmicrobiomemortalitymouse modelnew therapeutic targetnovelnovel therapeutic interventionpathogenresponsetherapeutic targettranscriptometranscriptome sequencingtranscriptomics
项目摘要
There has been a dramatic rise in the number of severe fungal infections due to a constant rise in the
number of individuals who are immunocompromised. Strong similarities in the basic eukaryotic metabolic
pathways between fungi and mammalian cells have hindered the development of antifungal agents because
many compounds that are effective at inhibiting fungal growth are also toxic to host cells. It is becoming clear
that novel antifungal agents alone are unlikely to significantly reduce the mortality rate of fungal infections
without the aid of new therapeutic approaches. One promising approach is to combine current antifungal
treatments with agents that enhance the host immune system's ability to eliminate the microbe. Such an
approach requires a detailed understanding of the complex interaction between host and pathogen.
Infections due to Candida, Aspergillus, and Mucorales are the most common fungal infections that are
associated with poor outcome. Together, these three phylogenetically and biologically distinct fungi are
responsible for approximately 90% of the invasive fungal infections that occurred in North America between
2004 and 2008. Here we will combine dual-species RNA-seq, comparative genome analysis, well established
animal models and fungal genetics to systematically and comprehensively analyze the host-pathogen
interactions of these diverse fungal pathogens. Analyzing all three different types of fungi using the
same approach will enable us to define commonalities as well as key differences among the organisms and
the responses they elicit in the host. The proposed studies will provide a wealth of information regarding
gene function and regulation in both the fungus and the host and will likely lead to the identification of novel
therapeutic targets to treat this increasingly serious cause of human disease.
严重真菌感染的数量急剧上升,由于在持续上升
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Vincent Michael Bruno其他文献
Vincent Michael Bruno的其他文献
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{{ truncateString('Vincent Michael Bruno', 18)}}的其他基金
Therapeutic targeting of growth factor receptors to treat Mucormycosis
生长因子受体的治疗靶向治疗毛霉菌病
- 批准号:
10409703 - 财政年份:2019
- 资助金额:
$ 50.08万 - 项目类别:
Therapeutic targeting of growth factor receptors to treat Mucormycosis
生长因子受体的治疗靶向治疗毛霉菌病
- 批准号:
10163795 - 财政年份:2019
- 资助金额:
$ 50.08万 - 项目类别:
Therapeutic targeting of growth factor receptors to treat Mucormycosis
生长因子受体的治疗靶向治疗毛霉菌病
- 批准号:
10630197 - 财政年份:2019
- 资助金额:
$ 50.08万 - 项目类别:
Therapeutic targeting of growth factor receptors to treat Mucormycosis
生长因子受体的治疗靶向治疗毛霉菌病
- 批准号:
9814832 - 财政年份:2019
- 资助金额:
$ 50.08万 - 项目类别:
Genomic and Transcriptomic Analysis of Invasive Fungal Pathogens
侵袭性真菌病原体的基因组和转录组分析
- 批准号:
10132960 - 财政年份:2014
- 资助金额:
$ 50.08万 - 项目类别:
Genomic and Transcriptomic Analysis of Invasive Fungal Pathogens
侵袭性真菌病原体的基因组和转录组分析
- 批准号:
10375510 - 财政年份:2014
- 资助金额:
$ 50.08万 - 项目类别:
Genomic and Transcriptomic Analysis of Invasive Fungal Pathogens
侵袭性真菌病原体的基因组和转录组分析
- 批准号:
10597151 - 财政年份:2014
- 资助金额:
$ 50.08万 - 项目类别:
Genomic and Transcriptomic Analysis of Invasive Fungal Pathogens
侵袭性真菌病原体的基因组和转录组分析
- 批准号:
9901444 - 财政年份:
- 资助金额:
$ 50.08万 - 项目类别:
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