In-vivo characterization of pancreatic field carcinogenesis using spatially resolved reflectance measurements via a fiber optic probe

通过光纤探针进行空间分辨反射测量来表征胰腺癌发生的体内特征

• 批准号: 9124066
• 负责人: Adam Eshein
• 金额: $ 3.75万
• 依托单位: NORTHWESTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2018-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9124066
• 关键词: Affect; Algorithms; Asses; Blinded; Collection; Detection; Diagnosis; Duodenum; Endoscopy; Engineering; Fiber Optics; Geometry; Goals; Human; Length; Light; Malignant Neoplasms; Malignant neoplasm of pancreas; Measurement; Measures; Modeling; Monte Carlo Method; Mucous Membrane; Neoplasm Metastasis; Optics; Organ; Pancreas; Pancreatic duct; Patients; Persons; Phase; Population; Procedures; Property; Risk; Sampling; Site; Source; Staging; Structure; Survival Rate; Symptoms; Techniques; Technology; Testing; Time; Tissues; Vascular blood supply; Work; cancer risk; cancer type; carcinogenesis; design; detector; high risk; human subject; improved; in vivo; light scattering; microbiome; minimal risk; nano; nanoscale; novel; pancreatic juice; pancreatic neoplasm; physical property; public health relevance; research clinical testing; screening; simulation; tumor progression

 DESCRIPTION (provided by applicant): Pancreatic cancer (PC) is the most deadly cancer with an overall 5-year survival rate of ~7% over the last decade. This is primarily because PC tends to develop surreptitiously over the course of multiple decades (i.e., over 20 years from initiation to metastasis) with no appreciable symptoms presenting until the very final stages of cancer progression. There are no techniques available which are suitable for population- wide screening of PC. The goal of this project is to develop and test a novel optical technology for the detection of PC. This technology will target the ultrastructural alterations presenting in Field Effect of Carcinogenesis (FC). FC is the phenomenon by which a number of physical alterations in tissue structure occur throughout an entire affected organ at an early time- point, long before metastasis. These physical alterations happen at subdiffractional (nano) length-scales. Light scattering techniques have shown the ability to detect and characterize these ultrastructural alterations in both in-vivo and ex-vivo studies for multiple cancer types. The purpose of this project is to extend on previous work and develop a noninvasive fiber optic probe for use during an upper endoscopy procedure to probe the periampullary region of the duodenum for ultrastructural alterations. The periampullary region of the duodenum serves as a surrogate site from which cancer risk status can be assessed, since it is exposed to the same milieu as the pancreatic duct (pancreatic juices and microbiome) and the pancreatic duct is not practical for probing. The approach of this project will be divided into roughly two phases: 1) an engineering phase and 2) a clinical testing phase. First I will develop simulations to accurately model the probe design. I will build, test, and validate the probe design with phantoms. The probe will then be tested with human subjects to develop a prediction rule for detecting pancreatic cancer, and finally the prediction rule will be validate with an independent set of patients.

 描述（由申请人提供）：胰腺癌（PC）是最致命的癌症，在过去十年中总体5年生存率约为7%。这主要是因为PC往往在几十年的时间里秘密发展（即，从开始到转移超过20年），直到癌症进展的最后阶段才出现明显的症状。目前还没有适用于在人群中筛查前列腺癌的技术。该项目的目标是开发和测试一种新的光学技术， 检测PC。 该技术将针对致癌场效应（FC）中存在的超微结构改变。FC是一种现象，通过这种现象，在转移之前很久的早期时间点，在整个受影响的器官中发生组织结构的许多物理改变。这些物理变化发生在亚衍射（纳米）长度尺度上。光散射技术已经显示出在多种癌症类型的体内和体外研究中检测和表征这些超微结构改变的能力。 本项目的目的是扩展以前的工作，并开发一种非侵入性的光纤探头，用于在上消化道内窥镜检查过程中探测十二指肠壶腹周围区域的超微结构改变。十二指肠的壶腹周围区域用作可以评估癌症风险状态的替代部位，因为它暴露于与胰管相同的环境（胰液和微生物组），并且胰管对于探测是不实际的。 该项目的方法将大致分为两个阶段：1）工程阶段和2）临床测试阶段。首先，我将开发模拟，以准确地模拟探头设计。我将构建，测试和验证的探针设计与幻影。然后将用人类受试者测试探针，以开发用于检测胰腺癌的预测规则，最后将用一组独立的患者验证预测规则。