Role of myosin 1e in podocyte biology and renal filtration
肌球蛋白 1e 在足细胞生物学和肾滤过中的作用
基本信息
- 批准号:9176093
- 负责人:
- 金额:$ 53.73万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2011
- 资助国家:美国
- 起止时间:2011-09-15 至 2021-07-31
- 项目状态:已结题
- 来源:
- 关键词:ActinsAnimal ModelArchitectureAreaAwardBindingBinding ProteinsBiologicalBiologyBundlingCell AdhesionCell-Cell AdhesionCellsChemicalsChronic Kidney FailureCuesDataDevelopmentDiagnosisDialysis procedureEnd stage renal failureEndocytosisEnvironmentEquilibriumEventExocytosisFiltrationFocal Segmental GlomerulosclerosisFunctional disorderGenerationsGenomicsGoalsHumanHypertensionImageIn VitroInjuryKidneyKidney TransplantationLinkMaintenanceMechanicsMediatingMembraneMicrofilamentsModelingMolecularMotorMotor ActivityMusMutationMyosin ATPasePatientsPhosphorylationPlayPositioning AttributePost-Translational Protein ProcessingPropertyProteinsPublic HealthRecoveryRegulationRenal functionResearchRoleSignal TransductionStructureSurfaceTestingTranscriptional RegulationWorkWound Healingbasebiophysical techniquescohortenvironmental adaptationglomerular filtrationin vivoinnovationpodocytepreventprotein complexprotein protein interactionresearch studyslit diaphragmtranscriptomics
项目摘要
Chronic kidney disease is a major public health concern in the US and
worldwide. Myosin 1e (Myo1e), an actin-dependent motor protein expressed in
glomerular visceral epithelial cells (podocytes), is necessary for normal glomerular
filtration in humans and mice. Myo1e is one of the components of the slit diaphragms,
protein complexes that connect adjacent podocytes and play a key role in selective
protein filtration in the glomerulus. Inactivating mutations in Myo1e are associated with
focal segmental glomerulosclerosis (FSGS), one of the leading causes of end stage
renal disease.
In this proposal, we will determine how actin-dependent motor activity of Myo1e
contributes to the maintenance of normal glomerular architecture and functions. We
hypothesize that Myo1e is necessary for podocyte adaptation to the changes in their
environment, including changes caused by high blood pressure and other pathological
conditions, via its role in regulating membrane tension and slit diaphragm stability. In this
application, we propose to study the role of Myo1e in tension generation and slit
diaphragm turnover using innovative biophysical and cell biological approaches. In Aim
1, we will determine how Myo1e-mediated tension regulates podocyte activity and allows
podocytes to adapt to the changing environment within the glomerulus under normal and
pathological conditions. In Aim 2, we will dissect Myo1e role in regulating slit diaphragm
assembly and turnover. In Aim 3, we will analyze the mechanisms responsible for
regulation of Myo1e expression and activity. These studies will help determine how
mutations in Myo1e contribute to development of FSGS and provide better
understanding of the regulation of podocyte structure and function.
慢性肾脏疾病是美国和欧洲主要的公共卫生问题
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Mira Krendel其他文献
Mira Krendel的其他文献
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{{ truncateString('Mira Krendel', 18)}}的其他基金
Role of myosin 1e in podocyte biology and renal filtration
肌球蛋白 1e 在足细胞生物学和肾滤过中的作用
- 批准号:
10587345 - 财政年份:2023
- 资助金额:
$ 53.73万 - 项目类别:
Design of the Glomerulus and bOwman cApsuLe on a chip (GOAL)
芯片上肾小球和鲍曼胶囊的设计(目标)
- 批准号:
10810038 - 财政年份:2023
- 资助金额:
$ 53.73万 - 项目类别:
Class I myosins regulate protrusive forces at the actin-membrane interface
I 类肌球蛋白调节肌动蛋白-膜界面的突出力
- 批准号:
10445354 - 财政年份:2021
- 资助金额:
$ 53.73万 - 项目类别:
Class I myosins regulate protrusive forces at the actin-membrane interface
I 类肌球蛋白调节肌动蛋白-膜界面的突出力
- 批准号:
10211206 - 财政年份:2021
- 资助金额:
$ 53.73万 - 项目类别:
Class I myosins regulate protrusive forces at the actin-membrane interface
I 类肌球蛋白调节肌动蛋白-膜界面的突出力
- 批准号:
10582145 - 财政年份:2021
- 资助金额:
$ 53.73万 - 项目类别:
Class I myosins regulate protrusive forces at the actin-membrane interface
I 类肌球蛋白调节肌动蛋白-膜界面的突出力
- 批准号:
10612046 - 财政年份:2021
- 资助金额:
$ 53.73万 - 项目类别:
Role of myosin 1e in podocyte biology and renal filtration
肌球蛋白 1e 在足细胞生物学和肾滤过中的作用
- 批准号:
8188190 - 财政年份:2011
- 资助金额:
$ 53.73万 - 项目类别:
Role of myosin 1e in podocyte biology and renal filtration
肌球蛋白 1e 在足细胞生物学和肾滤过中的作用
- 批准号:
8328733 - 财政年份:2011
- 资助金额:
$ 53.73万 - 项目类别:
Role of myosin 1e in podocyte biology and renal filtration
肌球蛋白 1e 在足细胞生物学和肾滤过中的作用
- 批准号:
8517103 - 财政年份:2011
- 资助金额:
$ 53.73万 - 项目类别:
Role of myosin 1e in podocyte biology and renal filtration
肌球蛋白 1e 在足细胞生物学和肾滤过中的作用
- 批准号:
8675846 - 财政年份:2011
- 资助金额:
$ 53.73万 - 项目类别:
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