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Targeting maladaptive responding to negative affect in adolescent cannabis users

针对青少年大麻使用者的负面影响的适应不良反应

基本信息

批准号：
9371970
负责人：
Kate Basia Wolitzky-Taylor
金额：
$ 14.87万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-15 至 2020-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9371970
关键词：
Adolescence Adolescent Adolescent and Young Adult Affect Affective Affective Symptoms Aftercare Alcohol or Other Drugs use Alcohols Amygdaloid structure Anxiety Behavior Therapy Behavioral Biological Markers Brain Brain imaging Cannabis Cognitive Cognitive Therapy Comorbidity Development Disease Drug usage Educational process of instructing Emotional Emotional disorder Emotions Exposure to Feedback Focus Groups Fright Functional Magnetic Resonance Imaging General Population Goals Individual Intervention Lead Link Maintenance Measurement Measures Medial Mediating Mediator of activation protein Mental Depression Mood Disorders Onset of illness Outcome Participant Pathologic Patient Self-Report Patients Population Process Protocols documentation Public Health Randomized Randomized Clinical Trials Reaction Recruitment Activity Regulation Research Risk Sampling Substance Addiction Substance Use Disorder Testing Time Tobacco Training Treatment outcome Work adolescent substance use aged alcohol and other drug anxiety sensitivity arm behavioral construct bodily sensation cognitive reappraisal craving design distress tolerance emerging adult emotion dysregulation emotion regulation emotional reaction emotional symptom evidence base follow up assessment follow-up high risk improved indexing individualized medicine marijuana use marijuana use disorder marijuana user mindfulness negative affect novel relating to nervous system response satisfaction screening skills standard care therapy outcome young adult

项目摘要

Project Summary This project aims to develop and evaluate a behavioral intervention for adolescent cannabis use disorder that emphasizes adaptive responding to negative affective symptoms (e.g., depression, anxiety). Maladaptive cognitive, behavioral, and emotional reactions to negative affect are associated with substance use and substance use problems (including cannabis). Adolescence and young adulthood represents a developmental period in which the regulation of negative emotions is still being developed, as well as a time when cannabis use is prevalent and cannabis use disorders onset. Thus, developing and evaluating cannabis use disorder interventions that emphasize the improvement of responding to negative affect may be particularly important for this developmental period. First, we will develop an intervention that weaves skills and strategies for responding adaptively to negative affect, particularly as it relates to high-risk times for cannabis craving and use, into an evidence-based substance use disorder intervention for individuals in late adolescence and early adulthood. After developing the initial protocol and delivering it to a small sample of participants, we will gather feedback to guide refinements to the intervention. After refining the intervention, which we plan to be a 12-session individual treatment, we will conduct the pilot randomized clinical trial. Participants (N = 80) aged 18-25 with cannabis use disorder and elevations in constructs representing maladaptive reactivity to negative affect (i.e., high anxiety sensitivity, low distress tolerance, or facets of emotion dysregulation including high emotional suppression and low cognitive reappraisal ability) will be randomized to receive either: (a) standard cognitive behavioral therapy for adolescent substance use disorders (SUD-CBT) or (b) the novel intervention we develop, affective management training for cannabis use disorders (CUD-AMT). Participants will be assessed at baseline, post-treatment, and a 6-month follow-up assessment on self-report and behavioral indices of the targeted mechanisms, as well as on substance use outcomes (both cannabis-specific and substances more broadly defined). A sub-set of participants (n = 50) will also undergo pre- and post-treatment fMRI assessment to evaluate whether neural indices of emotion regulation are improved to a greater extent in CUD-AMT compared to SUD-CBT. Cannabis use disorder is the most prevalent substance use disorder among adolescents and young adults, and often leads to the use of other substances. Negative affect and disorders associated with high negative affect (i.e., anxiety and unipolar mood disorders) are highly prevalent and associated with significant substance use disorder comorbidity. Targeting a process that is still malleable in late adolescence and young adulthood and that is associated with the maintenance of substance use disorders has the potential to reduce the burden of substance use disorders in this population, thus making a significant public health impact.

项目总结