BSLII Stationed Zeiss 880 Confocal Microscope with Airyscan

BSLII 固定式蔡司 880 共焦显微镜，带 Airyscan

• 批准号: 9274504
• 负责人: Havva Fitnat Yildiz
• 金额: $ 45.56万
• 依托单位: UNIVERSITY OF CALIFORNIA SANTA CRUZ
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-04-01 至 2019-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9274504
• 关键词: Animal Organ; Biological Sciences; Biomedical Research; California; Cell Communication; Cell Cycle; Confocal Microscopy; Core Facility; Equipment; Eye diseases; Funding; Immune; Immune Tolerance; Investigation; Lasers; Microbial Biofilms; Microscope; Microscopy; Movement; National Eye Institute; National Institute of Allergy and Infectious Disease; National Institute of General Medical Sciences; Pathogenesis; Request for Proposals; Research; Research Personnel; Retinal; Risk; Sampling; Scanning; Science; System; Training; United States National Institutes of Health; Universities; Work; cost effective; flexibility; fluorescence imaging; graduate student; instrument; next generation; programs

This proposal requests funds to purchase a laser scanning confocal microscope for a group of NIH-funded investigators from several departments at the University of California at Santa Cruz. The proposed Zeiss 880 system with Airyscan will replace our current Zeiss PASCAL confocal microscope, which was purchased through NIH's SIG mechanism and installed in 2004. The Zeiss LSM 880 is a flexible and modular confocal laser scanning microscope for high end fluorescence imaging. The LSM 880 is an outstanding choice for a core facility as it is well suited for the research objectives of our users, it is easy to use and provides a cost- effective solution to our research challenges. The proposed instrument is essential for NIH-funded biomedical research taking place at UC Santa Cruz. The major user group is funded by multiple NIH programs. These are the National Institute of Allergy and Infectious Diseases (NIAID), The National Institute of General Medical Sciences (NIGMS), National Eye Institute (NEI). They seek to bring the power of confocal microscopy to studies of bacterial pathogenesis and mechanism of biofilm formation, bacterial movement within animal organs, and immune cell interactions during immunological tolerance, investigation of cell cycle, degenerative eye diseases and retinal plasticity. This microscope system will become an integral part of UCSC's Life Sciences Microscopy Center, and will located in a BSLII designated space within our Biomedical Sciences building. This placement is required for work on Risk Group 2 samples. The facility is open to all NIH-funded investigators; thus, this equipment will enhance and sustain biomedical research on this campus, while providing advanced training to our graduate students and postdoctoral research fellows, thereby helping to create the next generation of biomedical investigators.

本提案请求为美国国立卫生研究院资助的一组研究人员购买激光扫描共聚焦显微镜

项目成果

A Conserved PP2A Regulatory Subunit Enforces Proportional Relationships Between Cell Size and Growth Rate.

保守的 PP2A 调节亚基强制细胞大小和生长速率之间的比例关系。

• DOI: 10.1534/genetics.119.301012
• 发表时间: 2019
• 期刊: Genetics
• 影响因子: 3.3
• 作者: Leitao,RicardoM;Jasani,Akshi;Talavara,RafaelA;Pham,Annie;Okobi,QuincyJ;Kellogg,DouglasR
• 通讯作者: Kellogg,DouglasR