Current Trends in Stem Cell Therapies

干细胞疗法的当前趋势

• 批准号: 9359106
• 负责人: Sham S. Kakar
• 金额: $ 12.88万
• 依托单位: UNIVERSITY OF LOUISVILLE
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-05-01 至 2022-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9359106
• 关键词: stem cell therapy; trend

PROJECT SUMMARY/ABSTRACT Stem cell biology has become one of the most exciting scientific areas of investigation. Stem cells are a key to understanding: i) the physiology of tissue rejuvenation, ii) organ regeneration after injury and iii) the regulation of the lifespan. A looming educational challenge is the preparation of young investigators to engage in research on these very important cells in the body. The focus of this training program “Current Trends in Stem Cell Therapies (CTSCT)” Training Program is to understand the role of stem cells in hematology and tissue injury. The training program is derived from the experience of mentoring faculty and the strength of clinical utilization of adult stem cells isolated from postnatal tissues in stem cell processing laboratories employed in the Bone Marrow Transplant Unit, Department of Cardiology, and the Department of Pediatrics at the University of Louisville (UofL). This grant will involve the post-doctoral fellows by engaging them in conceptual laboratory work aimed at the optimization of the: i) isolation of versatile populations of stem cells from adult issues, ii) their ex vivo expansion alone, or in combination with synthetic scaffolds iii) studies on the role of paracrine-related effects of stem cells in regeneration, with special emphasis on extracellular microvesicles (ExMV) and iv) strategies of stem cell delivery to damaged organs including mechanism orchestrating their homing and engraftment. The goals of our training program (CTSCT) will be achieved with a multidisciplinary approach that includes the dedicated faculty from various departments, centers, institutes, and schools. The highly experienced and multidisciplinary faculty at the UofL will provide critical resources and expertise in performing cutting-edge basic and clinical research in this field. This proposal is an innovative postdoctoral training program that will serve as a platform for developing interdisciplinary and integrated approaches that will shed more light on the stem cell compartment under steady-state and pathological conditions. The proposed training program will support five postdoctoral trainees. Two of them will be recruited in year one and then three more in year two to maintain a total of 5 trainees. These may be existing postdoctoral fellows who have matriculated at UofL, or candidates selected by an open recruitment from highly reputed research institutions. This training program will also serve as an important vehicle to integrate the stem cell research performed at UofL. This will be achieved by organizing integrated stem cell-related special courses, seminars, lectures, journal clubs, and open discussions to exchange new ideas among postdoctoral fellows participating in this program and with other students and faculty members at UofL. In addition, the teams of mentors (including both basic and clinical scientists) will promote the importance of multidisciplinary training and the translation of basic science research findings to the community of Kentucky. In summary, our CTSCT training program will effectively facilitate multidisciplinary approaches to studying stem cell biology and is consistent with the NIH Roadmap and the strategic plans of the NHLBI and the overall developmental goals of the UofL.

项目摘要/摘要 干细胞生物学已成为最令人兴奋的科学投资领域之一。干细胞是 理解：i）组织复兴的生理学，ii）受伤后的器官再生和iii）调节 寿命。迫在眉睫的教育挑战是年轻调查人员的准备 研究体内这些非常重要的细胞。该培训计划的重点“ STEM的当前趋势 细胞疗法（CTSCT）”培训计划是了解干细胞在血液学和组织中的作用 受伤。培训计划来自心理教师的经验和临床的力量 从干细胞加工实验室中从产后组织中分离出的成年干细胞的利用 骨髓移植单元，心脏病学系和儿科部门 路易斯维尔大学（UOFL）。这笔赠款将通过使他们参与概念的奖学金。 实验室工作旨在优化：i）从成人中隔离干细胞多功能种群 问题，ii）单独的离体扩展，或与合成支架结合使用iii）研究的作用 干细胞在再生中的旁分泌相关作用，特别强调细胞外微泡 （EXMV）和IV）干细胞输送到受损器官的策略，包括精心策划其机制 归巢和植入。我们的培训计划（CTSCT）的目标将通过多学科实现 包括来自各个部门，中心，机构和学校的专门教师。 UOFL经验丰富且多学科的教师将提供关键的资源和专业知识 在该领域进行尖端的基本和临床研究。该建议是创新的博士后 培训计划将作为开发跨学科和综合方法的平台 将在稳态和病理条件下对干细胞室的更多启发。 拟议的培训计划将支持五名博士后学员。其中两个将在第一年招募 然后在第二年又有三个，以维持5名学员。这些可能是现有的博士后研究员 已在UOFL矩阵，或者是由高度再现的候选人选择的候选人 机构。该培训计划还将成为整合干细胞研究的重要工具 在UOFL进行。这将通过组织综合干细胞相关的特殊课程，半小伙子， 讲座，期刊俱乐部和开放讨论，以交换博士后研究员的新想法 在该计划以及UOFL的其他学生和教职员工中。此外，导师团队 （包括基本科学家和临床科学家）将促进多学科培训的重要性和 将基础科学研究结果翻译给肯塔基州社区。总而言之，我们的CTSCT培训 程序将有效地促进多学科研究干细胞生物学的方法，并且是一致的 随着NIH路线图和NHLBI的战略计划以及UOFL的整体发展目标。