COG Biospecimen Bank

 描述(申请人提供)：儿童肿瘤学小组(COG)是国家临床试验网络(NCTN)的儿科临床试验小组。超过90%的美国和加拿大癌症儿童和青少年在COG机构接受治疗，没有种族、民族或地理上的登记偏见，允许进行几乎基于人群的临床、转化和基础研究。COG在收集和储存参加COG赞助的临床试验的患者的肿瘤和非疾病生物标本方面建立了良好的记录，这些试验大多包括随机治疗问题。COG生物谱库(COG BB)位于全国儿童医院生物病理学中心内，旨在为研究界提供高质量的儿童和青少年人类恶性生物谱库。每年，COG BB从来自225多个COG机构的大约5500名COG患者那里接收并储存超过10万份标本，并将大约10,000份标本分发给经批准的研究人员。该银行还提供诸如核酸分离、病理检查、虚拟显微镜、临床参考实验室测试和信息学倡议等服务。这项建议支持收集、处理和分发参加COG III期和大型II期试验(每年约4000名患者)的患者的生物标记物。COG BB寻求通过集中收集、质量控制、存储和分发程序，直接促进和支持儿科癌症诊断和治疗方面的杰出研究。COG BB将继续努力提供最新的基于生物库的技术创新和最佳实践，从而不断提高我们的操作能力、研究人员获得生物显微镜的机会、调查人员的满意度以及这些宝贵资源的管理。在适当的法规指导下，并与COG统计和数据中心合作，COG BB将通过确保适当跟踪生物样本以及与现有人口、临床、生物、治疗和结果数据的联系，支持尖端研究的翻译方面。最后，COG BB将为研究人员提供全面的数据库解决方案和动态信息学工具，以促进儿科癌症研究，包括使用Biosecimen IT Navigator和NCTN Biospecimen前门服务。

 DESCRIPTION (provided by applicant): The Children's Oncology Group (COG) is the pediatric clinical trials group of the National Clinical Trials Network (NCTN). Over 90% of United States and Canadian children and adolescents with cancer are treated at COG institutions with no racial, ethnic or geographic bias to registration, allowing for near-population-based clinical, translational and basic research. COG has established a strong track record of collecting and banking tumor and non-diseased biospecimens from patients enrolled in COG-sponsored clinical trials, most of which include randomized treatment questions. The COG Biospecimen Bank (COG BB), located within the Biopathology Center at Nationwide Children's Hospital, aims to provide high-quality pediatric and adolescent human malignant biospecimens to the research community. Annually, the COG BB receives and banks over 100,000 specimens from approximately 5,500 COG patients from over 225 COG institutions, and distributes approximately 10,000 specimens to approved investigators. The bank also offers services such as nucleic acid isolations, pathology review, virtual microscopy, clinical reference laboratory testing, and informatics initiatives. This proposal supports the collection, processing, and distribution of biospecimens from patient enrolled on COG Phase III and large Phase II trials (approximately 4,000 patients per year). The COG BB seeks to directly promote and support outstanding research in the diagnosis and treatment of pediatric cancer through centralized collection, quality control, storage, and distribution procedures. The COG BB will continue efforts to provide the latest biorepository based technological innovations and best practices, resulting in constant improvements in our operational capabilities, investigator access to biospecimens, investigator satisfaction, and the stewardship of these precious resources. Under proper regulatory guidelines and in association with the COG Statistical and Data Center, the COG BB will support translational aspects of cutting-edge research by ensuring appropriate tracking of biospecimens as well as linkages to existing demographic, clinical, biological, treatment, and outcome data. Finally the COG BB will provide investigators with a comprehensive database solution and dynamic informatics tools that facilitate pediatric cancer research, including the use of the Biospecimen IT Navigator and the NCTN Biospecimen front door services.