Diabetes and its Metabolic Complications

 描述(申请人提供)：糖尿病及其心脏代谢并发症正在迅速增加，并在美国和世界范围内造成巨大的公共健康和经济负担。为了遏制这一流行病，必须进行创新研究，这将需要培训新一代的多学科调查人员。拟议的马里兰大学糖尿病及其代谢并发症(DMC)T32培训计划将满足尚未得到满足的研究培训需求，这些培训专门专注于糖尿病从发现到实施到患者护理的基因组方法。我们要求在5年内每年支持2名博士后和2名博士后(博士、医学博士或医学博士/博士)研究员，以培养一批未来糖尿病翻译基因组研究的领导者。我们的T32课程侧重于三个相互提供信息的研究轨道，以推动基因组发现对治疗和预防糖尿病及其代谢并发症的新方法的新机制的理解：1)遗传学/基因组学；2)糖尿病、代谢综合征、肥胖及其心血管并发症的病理生理学；以及3)治疗策略。教学将被要求满足三个轨道中的一个的核心能力；然而，课程将提供足够的灵活性，以根据每个受训者的具体兴趣和需求进行个性化。公契学员将 沉浸在密集的、全面的、有指导的研究体验中。我们的16名DMC培训助学金教师都是经验丰富的导师，他们是独立的、资金充足的和富有成效的研究人员，他们在多学科团队中合作，涵盖遗传学/基因组学、分子、细胞和疾病的病理生理机制、转化研究以及以患者和人群为导向的研究。马里兰大学糖尿病翻译基因组研究的受训人员可获得的研究环境和资源非常丰富，其中包括NIH资助的大西洋中部营养性肥胖研究中心(NORC)和巴尔的摩糖尿病研究中心(DRC)。DMC教员的标志性项目之一是阿米什基因组研究计划，该计划为糖尿病翻译基因组学的培训和研究提供了前所未有的机会。DMC培训计划将由Alan Shuldiner博士和Michael Quon博士指导。我们计划的实施/发展，包括课程开发、从大量高素质申请者中挑选实习生、导师配对、对实习生/导师的跟踪/指导以及培训计划的评估，将由一个指导委员会监督，并由内部和外部咨询委员会进行计划监督。DMC T32培训计划将使马里兰大学资深资深教师能够培训、指导和培养杰出的博士前和博士后研究员，以便在专注于糖尿病翻译基因组学的生物医学研究的独立学术生涯中取得成功。这种培训对于有效解决与糖尿病及其代谢并发症有关的巨大公共卫生/经济成本至关重要。

 DESCRIPTION (provided by applicant): Diabetes and its cardiometabolic complications are growing rapidly, and creating overwhelming public health and economic burdens in the USA and worldwide. Innovative research is necessary to curb this pandemic, which will require the training of new generations of multidisciplinary investigators. The proposed University of Maryland T32 training program in Diabetes and Its Metabolic Complications (DMC) will fulfill an unmet need for research training specifically focused on genomic approaches to diabetes from discovery to implementation into patient care. We request support for 2 pre- and 2 post-doctoral (PhD, MD or MD/PhD) fellows annually for 5 years to create a cadre of future leaders in diabetes translational genomics research. Our T32 curriculum focuses on three mutually informative research tracks to advance genomic discoveries to new mechanistic understandings to novel approaches for treatment and prevention of diabetes and its metabolic complications: 1) Genetics/genomics; 2) Pathophysiology of diabetes, metabolic syndrome, obesity, and their cardiovascular complications; and 3) Therapeutic strategies. Didactics will be required to fulfill core competencies in one of the three tracks; however the curriculum will provide sufficient flexibility to individualize to the specific interests and needs of each trainee. DMC trainees will be immersed in an intensive, comprehensive, mentored research experience. Our 16 DMC Training Grant faculty are experienced mentors, independent well-funded and productive investigators who work together in multidisciplinary teams that span genetics/genomics, molecular, cellular, and pathophysiological mechanisms of disease, translational research, and patient- and population-oriented research. The research environment and resources available to trainees in diabetes translational genomics research at the University of Maryland are substantial and include the NIH-funded Mid-Atlantic Nutrition Obesity Research Center (NORC) and the Baltimore Diabetes Research Center (DRC). One of the signature programs of DMC faculty is the Amish Genomics Research Program, which provides unprecedented opportunities for training and research in diabetes translational genomics. The DMC Training Program will be directed by Drs. Alan Shuldiner and Michael Quon. Implementation/development of our program including curriculum development, trainee selection from a large pool of highly qualified applicants, mentor pairing, tracking/guidance of trainees/mentors, and evaluation of the Training Program will be overseen by a Steering Committee, with programmatic oversight by Internal and External Advisory Committees. The DMC T32 Training Program will enable senior accomplished University of Maryland faculty to train, mentor, and nurture exceptional pre- and post-doctoral fellows for success in independent scholarly careers in biomedical research focused on diabetes translational genomics. Such training is essential for effectively addressing enormous public health/economic costs associated with diabetes and its metabolic complications.