Mapping HPGe double-sided strip detector with x-rays for improved detector performance and position estimation
使用 X 射线映射 HPGe 双面条形探测器,以提高探测器性能和位置估计
基本信息
- 批准号:9353656
- 负责人:
- 金额:$ 2.87万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-09-01 至 2018-08-31
- 项目状态:已结题
- 来源:
- 关键词:AlgorithmsAnimalsAreaBiologicalCdZnTeChargeCompton radiationDataData SetDetectionDigital LibrariesDimensionsDiscipline of Nuclear MedicineElectronicsEstimation TechniquesEvaluationEventGamma CamerasGermaniumGoalsHeart DiseasesImageImaging TechniquesIndividualInjectableKnowledgeLaboratoriesLesionMapsMeasuresMental disordersMethodsMorphologic artifactsMyocardial perfusionNeurodegenerative DisordersNoisePerformancePhotonsPositioning AttributePropertyPulmonary EmbolismResearch TrainingResolutionRoentgen RaysSchemeScientistSemiconductorsShapesSideSignal TransductionSourceSystemTechniquesWidthanimal imagingcancer typecontrast imagingdetectorhigh resolution imagingimprovedinterestpublic health relevanceradiotracerresponsesignal processingsingle photon emission computed tomographytumor
项目摘要
DESCRIPTION (provided by applicant): Single Photon Emission Computed Tomography (SPECT) is a nuclear medicine imaging technique that allows for the mapping of the biological distribution of an injected radiotracer; depending on the type of radiotracer a range of topics may be studied, such as: mental and neurodegenerative disorders, various types of cancers, pulmonary embolisms, and heart disease. We are currently building a dual-headed SPECT system that uses double-sided strip, high-purity germanium (DSS HPGe) detectors. HPGe offers an energy resolution (FWHM < 1% at 140 keV) an order of magnitude better than conventional NaI gamma cameras, and its charge transport properties enable spatial resolutions similar to that of CdZnTe pixel detectors while using far fewer channels of readout electronics. The DSS configuration allows for sub-pixel positioning, however, multiple strip effects such as charge sharing, charge loss and Compton scattering within the detector can cause the events to be mis- positioned and/or uncounted. This decreases detection efficiency and overall sensitivity, possibly leading to artifacts in the reconstructed image. Alternative, advanced post-processing techniques have been shown to correct for these effects in limited cases (specific detector configurations and/or only small detector areas investigated). The goal of this proposed study is to investigate and implement the following post-processing techniques: waveform analysis, Maximum-Likelihood (ML) estimation, and charge loss correction across the whole detector. This will be done in three aims: Aim 1) Carefully measure the detector system response using the Advanced Photon Source (APS) at Argonne National Laboratory, Aim 2) Perform the position estimation techniques on the data obtained in aim 1. With these data sets (one for each technique) and knowledge of the beam position the three-dimensional position of each event may be determined using the ML estimation (note that one technique is to try the ML method without additional post-processing). Each technique will be evaluated by measuring: uniformity, energy and spatial resolution, and evaluation of a projected image (spatial resolution, signal- and contrast-to-noise ratio, modulation transfer function, etc), and Aim 3) Implement the new position estimation technique with the new SPECT system and evaluate the differences between the new reconstructed image compared to our current post-processing technique. We expect to obtain reconstructed SPECT images that have higher resolution, sensitivity, and contrast, as well as fewer artifacts, leading to better detectability.
描述(由申请人提供):单光子发射计算机断层扫描(SPECT)是一种核医学成像技术,可以绘制注射放射性示踪剂的生物分布图;根据放射性示踪剂的类型,可以研究一系列主题,例如:精神和神经退行性疾病、各种类型的癌症、肺栓塞和心脏病。我们目前正在构建一个双头 SPECT 系统,该系统使用双面带状高纯锗 (DSS HPGe) 探测器。 HPGe 的能量分辨率(140 keV 时 FWHM < 1%)比传统 NaI 伽玛相机高一个数量级,其电荷传输特性可实现与 CdZnTe 像素探测器相似的空间分辨率,同时使用的读出电子器件通道少得多。 DSS 配置允许子像素定位,然而,检测器内的多重条带效应(例如电荷共享、电荷损失和康普顿散射)可能导致事件定位错误和/或未计数。这降低了检测效率和整体灵敏度,可能导致重建图像中出现伪影。替代性的先进后处理技术已被证明可以在有限的情况下(特定的探测器配置和/或仅研究较小的探测器区域)纠正这些影响。这项研究的目标是研究和实施以下后处理技术:波形分析、最大似然 (ML) 估计和整个探测器的电荷损失校正。这将实现三个目标: 目标 1) 使用阿贡国家实验室的高级光子源 (APS) 仔细测量探测器系统响应,目标 2) 对目标 1 中获得的数据执行位置估计技术。利用这些数据集(每种技术一个)和光束位置知识,可以使用 ML 估计来确定每个事件的三维位置(请注意,一种技术是尝试 ML 方法,无需额外的后处理)。每种技术将通过以下测量进行评估:均匀性、能量和空间分辨率,以及投影图像的评估(空间分辨率、信噪比和对比度、调制传递函数等),目标 3) 使用新的 SPECT 系统实施新的位置估计技术,并评估新的重建图像与我们当前的后处理技术之间的差异。我们期望获得具有更高分辨率、灵敏度和对比度以及更少伪影的重建 SPECT 图像,从而获得更好的可检测性。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Rose Schmitt Perea其他文献
Rose Schmitt Perea的其他文献
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{{ truncateString('Rose Schmitt Perea', 18)}}的其他基金
Mapping HPGe double-sided strip detector with x-rays for improved detector performance and position estimation
使用 X 射线映射 HPGe 双面条形探测器,以提高探测器性能和位置估计
- 批准号:
9126689 - 财政年份:2016
- 资助金额:
$ 2.87万 - 项目类别:
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