Interdisciplinary Research in Vascular Biology

 描述(由申请人提供)：在这份Cobre第三期申请中，我们将在俄克拉荷马医学研究基金会(OMRF)建立一个世界级的血管生物学卓越中心。在第一和第二阶段，我们通过多学科方法促进了血管生物学研究。导师开始了杰出的初级调查人员的独立职业生涯，他们开发了创新的新技术，在顶级期刊上发表了论文，并成功地竞争了NIH、国防部、NSF和其他来源的多项拨款。我们支持发展促进研究项目的核心设施。我们的几个科学核心已经在财务上独立了。在第三阶段，我们将扩展和过渡到可持续发展两个科学核心，支持所有Cobre研究人员和非Cobre研究人员的心血管研究。显微镜核心提供了使用最先进的显微镜对体外和体内组织成像的独特专业知识。表型鉴定核心提供独特的专业知识和设备来评估心血管生理学和病理学。试点核心将确定和支持符合Cobre资格的初级调查人员的创新试点项目。这将扩大中心内研究的范围和深度，并进一步提高资金的竞争力。行政核心将协调科学核心，协助监管要求，评估试点项目，最重要的是，培育我们强大的指导环境，以确保其可持续性。OMRF将通过在工资、资本设备、实验室空间和教师招聘方面的承诺，继续与Cobre合作。第三阶段的资金将确保我们过渡到一个自给自足的最高水平的血管生物学研究中心。

 DESCRIPTION (provided by applicant): In this COBRE Phase III application, we will move to independence a world-class center of excellence in vascular biology at the Oklahoma Medical Research Foundation (OMRF). In Phases I and II, we fostered vascular biology research through a multidisciplinary approach. Mentoring launched the independent careers of outstanding junior investigators, who developed innovative new technologies, published papers in top-tier journals, and competed successfully for multiple grants from NIH, DOD, NSF, and other sources. We supported development of core facilities that enhanced the research projects. Several of our scientific cores are already financially independent. In Phase III we will expand and transition to sustainability two scientific cores that support cardiovascular research for all COBRE investigators and for non-COBRE investigators. The Microscopy Core provides unique expertise to image tissues in vitro and in vivo using state-of-the-art microscopes. The Phenotyping Core provides unique expertise and equipment to assess cardiovascular physiology and pathology. The Pilot Core will identify and support innovative pilot projects from COBRE- eligible junior investigators. These will expand the scope and depth of research within the Center and further improve competitiveness for funding. The Administrative Core will coordinate the scientific cores, assist with regulatory requirements, evaluate the pilot projects, and, most importantly, nurture our strong mentoring environment to ensure its sustainability. OMRF will continue to partner with the COBRE through commitments to salaries, capital equipment, laboratory space, and faculty recruitment. Phase III funding will ensure our transition to a self-sustaining research center in vascular biology of the highest caliber.