Interdisciplinary Research in Vascular Biology

 描述（由申请人提供）：在本COBRE III期申请中，我们将独立于俄克拉荷马州医学研究基金会（OMRF）的世界级血管生物学卓越中心。在第一和第二阶段，我们通过多学科方法促进血管生物学研究。指导启动了杰出的初级研究人员的独立职业生涯，他们开发了创新的新技术，在顶级期刊上发表论文，并成功地获得了NIH，DOD，NSF和其他来源的多项赠款。我们支持发展核心设施，以加强研究项目。我们的几个科学核心已经在财政上独立了。在第三阶段，我们将扩大并过渡到可持续发展的两个科学核心，支持所有COBRE研究者和非COBRE研究者的心血管研究。显微镜核心提供独特的专业知识，使用最先进的显微镜在体外和体内成像组织。Phenotyping Core提供独特的专业知识和设备来评估心血管生理学和病理学。试点核心将从符合COBRE资格的初级研究者中识别和支持创新试点项目。这将扩大中心内研究的范围和深度，并进一步提高资金的竞争力。行政核心将协调科学核心，协助监管要求，评估试点项目，最重要的是，培养我们强大的指导环境，以确保其可持续性。OMRF将继续通过对工资、资本设备、实验室空间和教师招聘的承诺与COBRE合作。第三阶段的资金将确保我们过渡到一个自我维持的研究中心，在血管生物学的最高水平。

 DESCRIPTION (provided by applicant): In this COBRE Phase III application, we will move to independence a world-class center of excellence in vascular biology at the Oklahoma Medical Research Foundation (OMRF). In Phases I and II, we fostered vascular biology research through a multidisciplinary approach. Mentoring launched the independent careers of outstanding junior investigators, who developed innovative new technologies, published papers in top-tier journals, and competed successfully for multiple grants from NIH, DOD, NSF, and other sources. We supported development of core facilities that enhanced the research projects. Several of our scientific cores are already financially independent. In Phase III we will expand and transition to sustainability two scientific cores that support cardiovascular research for all COBRE investigators and for non-COBRE investigators. The Microscopy Core provides unique expertise to image tissues in vitro and in vivo using state-of-the-art microscopes. The Phenotyping Core provides unique expertise and equipment to assess cardiovascular physiology and pathology. The Pilot Core will identify and support innovative pilot projects from COBRE- eligible junior investigators. These will expand the scope and depth of research within the Center and further improve competitiveness for funding. The Administrative Core will coordinate the scientific cores, assist with regulatory requirements, evaluate the pilot projects, and, most importantly, nurture our strong mentoring environment to ensure its sustainability. OMRF will continue to partner with the COBRE through commitments to salaries, capital equipment, laboratory space, and faculty recruitment. Phase III funding will ensure our transition to a self-sustaining research center in vascular biology of the highest caliber.