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Multi-modal treatment for neonatal HIE: hypothermia and dendrimer nanotherapy

Multi-modal treatment for neonatal HIE: hypothermia and dendrimer nanotherapy
新生儿 HIE 的多模式治疗：低温和树枝状大分子纳米疗法
批准号：
9318308
负责人：
MARY A WILSON
金额：
$28.53万
依托单位：
HUGO W. MOSER RES INST KENNEDY KRIEGER
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/9318308
关键词：
AcuteAddressAgeAnimal ModelAnti-Inflammatory AgentsAnti-inflammatoryAsphyxia NeonatorumAstrocytesAutistic DisorderBehavioralBrainBrain Hypoxia-IschemiaBrain InjuriesCell DeathCerebral PalsyChildChildhoodChronicComplementary therapiesConsumptionControl AnimalCysteineDataDendrimersDevelopmental DisabilitiesDiseaseDrug Delivery SystemsEmployee StrikesEquilibriumFemaleGlutathioneGoalsHistologicHumanHydroxyl RadicalImmuneIncidenceInfantInflammationInflammatoryInflammatory ResponseInjuryInterventionIntravenousLabelLipid PeroxidationLipid PeroxidesMeasuresMental Retardation and Developmental Disabilities Research CentersMicrogliaModalityModelingMusNF-kappa BNanotechnologyNeonatalNeurodevelopmental DisabilityNeurodevelopmental DisorderNeuronsNuclear TranslocationOutcomeOxidation-ReductionPathway interactionsPerinatal HypoxiaPerinatal anoxic ischemic brain injuryPharmaceutical PreparationsPhosphorylationPreventionRIPK1 geneRIPK3 geneResearchRewarmingSERPINA4 geneSeizuresSignal TransductionTP53 geneTherapeuticTranslational ResearchTreatment EfficacyWorkcellular targetingcyanine dye 5cytokinedisabilityimprovedinjuredmalemortalitymouse modelnanoparticlenanotherapeuticnanotherapynatural hypothermianeonatal hypoxic-ischemic brain injuryneonateneurobehavioralneuroprotectionpostnataltargeted deliverytreatment effecttreatment strategy

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