Multi-modal treatment for neonatal HIE: hypothermia and dendrimer nanotherapy

新生儿 HIE 的多模式治疗：低温和树枝状大分子纳米疗法

• 批准号: 9318308
• 负责人: MARY A WILSON
• 金额: $ 28.53万
• 依托单位: HUGO W. MOSER RES INST KENNEDY KRIEGER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9318308
• 关键词: Acute; Address; Age; Animal Model; Anti-Inflammatory Agents; Anti-inflammatory; Asphyxia Neonatorum; Astrocytes; Autistic Disorder; Behavioral; Brain; Brain Hypoxia-Ischemia; Brain Injuries; Cell Death; Cerebral Palsy; Child; Childhood; Chronic; Complementary therapies; Consumption; Control Animal; Cysteine; Data; Dendrimers; Developmental Disabilities; Disease; Drug Delivery Systems; Employee Strikes; Equilibrium; Female; Glutathione; Goals; Histologic; Human; Hydroxyl Radical; Immune; Incidence; Infant; Inflammation; Inflammatory; Inflammatory Response; Injury; Intervention; Intravenous; Label; Lipid Peroxidation; Lipid Peroxides; Measures; Mental Retardation and Developmental Disabilities Research Centers; Microglia; Modality; Modeling; Mus; NF-kappa B; Nanotechnology; Neonatal; Neurodevelopmental Disability; Neurodevelopmental Disorder; Neurons; Nuclear Translocation; Outcome; Oxidation-Reduction; Pathway interactions; Perinatal Hypoxia; Perinatal anoxic ischemic brain injury; Pharmaceutical Preparations; Phosphorylation; Prevention; RIPK1 gene; RIPK3 gene; Research; Rewarming; SERPINA4 gene; Seizures; Signal Transduction; TP53 gene; Therapeutic; Translational Research; Treatment Efficacy; Work; cellular targeting; cyanine dye 5; cytokine; disability; improved; injured; male; mortality; mouse model; nanoparticle; nanotherapeutic; nanotherapy; natural hypothermia; neonatal hypoxic-ischemic brain injury; neonate; neurobehavioral; neuroprotection; postnatal; targeted delivery; treatment effect; treatment strategy

No abstract provided

未提供摘要