Addressing Low Vision due to Severe Peripheral Field Loss: Development and Validation of a Patient-Centered Outcome Measure

解决因严重周边视野丧失导致的低视力问题：以患者为中心的结果测量的开发和验证

• 批准号: 9294683
• 负责人: Joshua Robert Ehrlich
• 金额: $ 22.45万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-01 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9294683
• 关键词: Activities of Daily Living; Address; Affect; Area; Attenuated; Awareness; Behavior; Blindness; Caregivers; Caring; Chronic; Clinical; Clinical Research; Clinical Trials; Cognitive; Consensus; Data; Development; Dorsal; Effectiveness; Ensure; Evaluation; Focus Groups; Future; Glaucoma; Goals; Hispanics; Impairment; Individual; Institutes; Intervention; Interview; Journals; Knowledge; Life; Measurement; Measures; Mentors; Mentorship; Methodology; Methods; Michigan; Mission; Modeling; Motion Perception; Motor; National Eye Institute; Ophthalmologist; Ophthalmology; Outcome; Outcome Measure; Outcomes Research; Pathway interactions; Patient Outcomes Assessments; Patient-Focused Outcomes; Patients; Peripheral; Population; Population Intervention; Prevalence; Principal Component Analysis; Provider; Psychometrics; Public Health; Quality of life; Randomized Controlled Trials; Rehabilitation therapy; Research; Research Design; Research Personnel; Research Priority; Retinal Degeneration; Review Literature; Self-Direction; Self-Help Devices; Stream; Surveys; Testing; Training; United States; University resources; Validation; Validity and Reliability; Vision; Vision Disorders; Vision Tests; Visual Acuity; Visual Fields; Visual impairment; Work; blind; career; career development; compare effectiveness; design; functional disability; improved; improved functioning; information processing; insight; instrument; patient oriented; programs; rehabilitation strategy; response; skills; spatial vision; systematic review; theories; vision rehabilitation; visual processing

Abstract The burden of blindness and visual impairment in the United States is expected to double between 2015 and 2050 to 8.96 million people. Blacks, Hispanics and older individuals will be disproportionally affected, further accentuating the disparate impact of vision disorders. Although low vision rehabilitation (LVR) has been shown to improve the functioning of patients, considerable opportunities remain to better understand and overcome functional limitations due to low vision. Specifically, the effectiveness of LVR for patients with peripheral field loss (PFL) has not been well-studied, though 15-20% of patients presenting for LVR have glaucoma or a retinal degeneration, two important causes of PFL. In order to evaluate and compare interventions for this population, a highly relevant measure of functioning is needed. The proposed project will address this through the development and validation of a patient-reported outcome measure, the Low Vision Severely Constricted Peripheral Eyesight (LV-SCOPE) Assessment. In Aim 1 of this proposal, focus groups with patients, caretakers and vision providers will identify the impairments and LVR goals associated with severe PFL. Since PFL often exists in combination with visual acuity loss, patients with PFL and a range of visual acuities will be included. We anticipate that PFL will preferentially impact known functions of the dorsal visual processing stream, as this pathway depends on peripheral vision for spatial awareness and motor behavior. In Aim 2, focus group data will guide the selection of survey items for the outcome measure. In Aim 3, psychometric evaluations will test the validity, reliability and precision of the LV-SCOPE. Once validated, the LV-SCOPE may be an optimal outcome measure to evaluate and identify targeted LVR strategies for patients with PFL, a sizable understudied population. This project directly addresses the National Eye Institute's low vision priority research area “to create and validate vision tests relevant for the tasks of daily living.” Dr. Ehrlich's long-term career goal is to improve the vision-dependent functioning of patients with low vision. He will achieve this through coursework, mentorship and research to improve the measurement of functional impairment and facilitate the evaluation of targeted LVR strategies. The applicant's training plan is a natural progression from his background in ophthalmology, clinical research and public health. He will acquire knowledge and expertise in outcome measure development and psychometrics, low vision and rehabilitation, mixed-methods analyses and clinical trials. Dr. Ehrlich has devised a plan of pertinent coursework, individualized mentorship, and directed self-study to achieve his training and research goals. Dr. Ehrlich's career development will benefit from the vast resources of the University of Michigan and the support of his mentors, including Drs. Noelle Carlozzi, Paul Lee, Robert Massof and Joan Stelmack. This proposal demonstrates Dr. Ehrlich's commitment to gaining the necessary skills to become an independent investigator and to addressing a pressing public health need.

摘要 美国失明和视力障碍的负担预计将在2015年至2019年期间翻一番。 2050至896万人。黑人、西班牙裔和老年人将受到更大的影响， 强调视觉障碍的不同影响。虽然低视力康复（LVR）已被证明 为了改善患者的功能，还有相当多的机会可以更好地理解和克服 由于视力低下导致的功能限制。具体而言，LVR对外周野患者的有效性 尽管15 - 20%的LVR患者患有青光眼或视网膜脱离，但LVR的PFL尚未得到充分研究。 变性，PFL的两个重要原因。为了评估和比较针对该人群的干预措施， 需要一个高度相关的运作措施。拟议项目将通过以下方式解决这一问题： 开发和验证患者报告的结局指标，低视力严重收缩 周边视力（LV-SCOPE）评估。在本提案的目标1中， 视力提供者将确定与严重PFL相关的损害和LVR目标。由于PFL经常 合并视力丧失，将纳入PFL和一系列视力的患者。 我们预计，PFL将优先影响背侧视觉处理流的已知功能，因为这 路径依赖于周边视觉的空间意识和运动行为。在目标2中，焦点小组数据 将指导成果计量的调查项目的选择。在目标3中，心理测量评估将测试 LV-SCOPE的效度、信度和精密度。一旦验证，LV-SCOPE可能是最佳的 一项评估和确定PFL患者的靶向LVR策略的结果指标， 被忽视的人群这个项目直接解决了国家眼科研究所的低视力优先研究 创建和验证与日常生活任务相关的视力测试。埃利希博士的长期职业目标 是改善低视力患者的视觉依赖功能。他将通过 课程，指导和研究，以改善功能障碍的测量和促进 评估有针对性的LVR策略。申请人的培训计划是从他的 具有眼科学、临床研究和公共卫生背景。他将获得知识和专业知识， 结果测量开发和心理测量、低视力和康复、混合方法分析和 临床试验埃利希设计了一个相关的课程计划，个性化的指导，并指导 自学，以实现他的培训和研究目标。埃利希博士的职业发展将受益于广大 密歇根大学的资源和他的导师，包括博士的支持。 作者声明：Robert Massof and Joan Stelmack.该提案表明了埃利希博士致力于获得 成为独立调查员和解决紧迫的公共卫生需求所需的必要技能。