A longitudinal epidemiological and epidemiological study of malaria and its vectors in the Kinshasa province

金沙萨省疟疾及其媒介的纵向流行病学和流行病学研究

• 批准号: 9275561
• 负责人: Antoinette Kitoto Tshefu
• 金额: $ 13.42万
• 依托单位: KINSHASA SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-05-01 至 2022-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9275561
• 关键词: Adult; Affect; Africa South of the Sahara; Age; Amodiaquine; Antimalarials; Area; Behavior; Biological Assay; Biology; Blood; Child; Clinical; Clinical Data; Communities; Country; Culicidae; Data; Democratic Republic of the Congo; Drug resistance; Entomology; Epidemiology; Event; Fansidar; Frequencies; Funding; Genes; Genetic; Genotype; Goals; Grant; Health; Health Surveys; High Prevalence; Home environment; Hospitals; Household; Incidence; Individual; Insecticide Resistance; Knowledge; Legal patent; Longitudinal Studies; Longitudinal cohort study; Malaria; Measures; Methodology; Microscopy; Molecular; Mutation; North Carolina; Outcome; Ownership; Parasitemia; Parasites; Participant; Pattern; Pharmaceutical Preparations; Population; Prevalence; Prospective Studies; Province; Ramp; Recording of previous events; Research; Research Infrastructure; Resistance; Resources; Risk; Risk Factors; Site; Spottings; Statistical Models; Sustainable Development; System; Testing; Time; Travel; United States National Institutes of Health; Universities; Visit; artesunate; cofactor; deletion detection; epidemiology study; evidence base; innovation; insight; longitudinal human study; malaria infection; malaria transmission; prospective; time use; transmission process; vector

Malaria is highly endemic in the Democratic Republic of the Congo (DRC). Malaria control efforts in the DRC have ramped up in recent years, but resources and local knowledge are still limited. The overall research goal of this project is to provide the evidence base to assist in the development of sustainable control and elimination strategies for the DRC through the integrated understanding of the local malaria epidemiology, vector biology and parasite genetics. Through a longitudinal cohort study of 1600 individuals in 7 sites with differing transmission intensities, we will: 1) identify risk factors for patent, subpatent and clinical malaria in a longitudinal study; 2) Assess changes in entomological parameters longitudinally including species, behavior and insecticide-resistance; 3) Measure genetic changes in the parasite longitudinally especially in drug-resistance SNPs and in deletions of the pfhrp2 gene; and 4) create multilevel statistical models to determine the relationships between these cofactors and events. The results of this study will have a direct impact on malaria control efforts in the DRC and other countries in sub-Saharan Africa.

疟疾在刚果民主共和国（DRC）是高度流行病。非洲防治疟疾工作 刚果民主共和国近年来有所增加，但资源和当地知识仍然有限。整体 本项目的研究目标是为可持续发展提供证据基础， 通过对当地疟疾的综合了解， 流行病学、病媒生物学和寄生虫遗传学。通过对1600名受试者的纵向队列研究， 在具有不同传播强度的7个地点的个体中，我们将：1）识别专利的风险因素， 在一项纵向研究中，对亚显性疟疾和临床疟疾进行评估; 2）评估昆虫学参数的变化 纵向包括物种，行为和抗逆性; 3）测量遗传变化， 纵向寄生虫，特别是在耐药性SNP和pfhrp 2基因缺失中;和4） 创建多层次统计模型，以确定这些辅助因子和事件之间的关系。 这项研究的结果将对刚果民主共和国和其他国家的疟疾控制工作产生直接影响。 撒哈拉以南非洲国家。