Individualized-Targeted Cognitive Training in Older Adults with HAND

HAND 对老年人进行个体化针对性认知训练

基本信息

  • 批准号:
    9198361
  • 负责人:
  • 金额:
    $ 22.28万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2016
  • 资助国家:
    美国
  • 起止时间:
    2016-12-22 至 2018-11-30
  • 项目状态:
    已结题

项目摘要

ABSTRACT Over 50% of adults with HIV have some form of HIV-Associated Neurocognitive Disorder (HAND) which represents a significant symptom that interferes with everyday functioning and quality of life. As adults age with HIV, they are more likely to develop comorbidities such as cardiovascular disease, hypertension, and insulin resistance which will further contribute to poorer cognitive functioning and HAND. Based upon the Frascati criteria, HAND is diagnosed when a person performs less than 1 to 2 SD below their normative mean (education & age) on measures of two or more cognitive domains (e.g., attention, speed of processing, verbal memory, executive functioning). Yet, from the cognitive literature and our prior studies, we know we can administer certain computerized cognitive training programs to improve specific cognitive domains in older adults and those with HIV. Such cognitive training programs may be effective in older adults with HIV and therefore we may be able to change the diagnosis of HAND in such cognitively vulnerable adults. In this pre- post experimental study, 146 older adults (50+) with HAND will be randomized to be in either: 1) the Individualized-Targeted Cognitive Training, or 2) a no-contact control group. We will focus on those cognitive domains in which participants express an impairment and train them with the corresponding cognitive program. Such an Individualized-Targeted Cognitive Training approach using standard cognitive training programs may offer hope and symptom relief to those individuals diagnosed with HAND. Furthermore, we assert that these changes will result in improved everyday functioning (e.g., IADLs) and quality of life. This approach represents a paradigm shift in possibly changing the way we look at HAND. Specific Aim 1: Compare adults who do receive Individualized-Targeted Cognitive Training to those who do not in order to determine whether a change in HAND prevalence and severity occurs between groups. Exploratory Aim 1: Compare adults who do receive individualized-targeted cognitive training to those who do not in order to determine whether this improves everyday functioning (e.g., IADLs). Exploratory Aim 2: Determine whether improvements in HAND and/or everyday functioning over time mediate improvements in quality of life.
摘要 超过50%的成年艾滋病毒感染者患有某种形式的艾滋病毒相关神经认知障碍(HAND), 代表干扰日常功能和生活质量的显著症状。随着成年人年龄的增长 艾滋病毒感染者更容易患上心血管疾病、高血压等并发症, 胰岛素抵抗,这将进一步导致认知功能和HAND较差。基于 Frascati标准,当一个人的表现低于其正常平均值1至2 SD时,即可诊断为HAND (教育和年龄)对两个或多个认知领域的测量(例如,注意力、处理速度、语言 记忆、执行功能)。然而,从认知文献和我们先前的研究中,我们知道我们可以 管理某些计算机认知训练计划,以改善老年人的特定认知领域, 成年人和艾滋病毒携带者。这种认知训练计划可能对老年艾滋病毒感染者有效, 因此,我们也许能够改变对这些认知脆弱的成年人的HAND诊断。在这场预- 实验研究后,146名患有HAND的老年人(50岁以上)将随机分为:1) 个体化定向认知训练,或2)无接触对照组。我们将重点关注那些认知 在这些领域中,参与者表达了一种障碍,并用相应的认知程序对他们进行培训。 这种使用标准认知训练程序的个体化定向认知训练方法可以 为那些被诊断患有HAND的人提供希望和症状缓解。此外,我们认为, 改变将导致改善的日常功能(例如,IADL)和生活质量。这种方法代表 一个可能改变我们看待手的方式的范式转变。具体目标1:比较那些 接受针对性的个性化认知训练,以确定是否改变 在HAND中,患病率和严重程度在组间发生。探索性目标1:比较那些接受 对那些没有进行个性化针对性认知训练的人进行个性化针对性认知训练,以确定这是否会改善 日常功能(例如,IADL)。探索性目标2:确定HAND和/或 随着时间的推移,日常功能会介导生活质量的改善。

项目成果

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DAVID E VANCE其他文献

DAVID E VANCE的其他文献

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{{ truncateString('DAVID E VANCE', 18)}}的其他基金

Executive Function Training to Reduce Cognitive Intra-Individual Variability in Adults with HIV
执行功能训练可减少成人艾滋病毒感染者的认知个体差异
  • 批准号:
    10689099
  • 财政年份:
    2022
  • 资助金额:
    $ 22.28万
  • 项目类别:
An RCT of Speed of Processing Training in Middle-Aged and Older Adults with HIV
中老年艾滋病病毒感染者处理速度训练的随机对照试验
  • 批准号:
    9251328
  • 财政年份:
    2016
  • 资助金额:
    $ 22.28万
  • 项目类别:
Chronicity of HIV and Aging on Neuropsychological and Everyday Performance
艾滋病毒慢性化和衰老对神经心理和日常表现的影响
  • 批准号:
    7614992
  • 财政年份:
    2008
  • 资助金额:
    $ 22.28万
  • 项目类别:

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