Homeostatic Stabilization of Neural Function in Health and Disease

健康和疾病中神经功能的稳态稳定

基本信息

项目摘要

PROJECT SUMMARY/ABSTRACT The brain is astonishing in its complexity and capacity for change. It seems certain that the plasticity that drives our ability to learn and remember can only be meaningful in the context of otherwise stable, reproducible, and predictable baseline neural function. It is now clear that homeostatic signaling systems function throughout the central and peripheral nervous systems to stabilize neural function throughout life. As a consequence, it is widely believed that impaired or maladaptive homeostatic signaling will be directly relevant to the cause and progression of neurological diseases that include epilepsy, autism and neurodegeneration. However, despite widespread evidence for the homeostatic control of neural function throughout the animal kingdom and implicit relevance to disease and aging, very little is known about the underlying mechanisms. The field of homeostatic plasticity is wide open for exploration and the potential for transformative advancement in cellular and molecular neuroscience is tremendous. We are leading the rapidly emerging field of homeostatic plasticity, harnessing the power of unbiased model system genetics to identify and characterize fundamentally new cellular and molecular mechanisms of homeostatic signaling in the nervous system. Our experiments will define many of the first signaling pathways identified to participate in the homeostatic signaling systems that control presynaptic neurotransmitter release and intrinsic neural excitability. Our approaches have uncovered a novel activity of the innate immune signaling system, new trans-synaptic signaling pathways, novel calcium sensors, novel neuronal kinase signaling systems, new roles for the presynaptic endoplasmic reticulum and tangible links to neurological disease. As such, our data will provide a foundation for exploring the impact homeostatic plasticity in mammalian models of neurological disease including epilepsy, autism and neurodegeneration. Our data will also directly impact current theories and models of homeostatic signaling. Current theoretical models have captured widespread interest. Molecular insight will provide important new ideas and new constraints for the next generation of theoretical models of homeostatic plasticity, learning and memory.
项目总结/文摘

项目成果

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GRAEME W DAVIS其他文献

GRAEME W DAVIS的其他文献

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{{ truncateString('GRAEME W DAVIS', 18)}}的其他基金

Homeostatic Neuroprotection in the Aging Nervous System
衰老神经系统的稳态神经保护
  • 批准号:
    10633619
  • 财政年份:
    2023
  • 资助金额:
    $ 101万
  • 项目类别:
Homeostatic Plasticity in Mouse Model of Jordan's Syndrome
乔丹氏综合症小鼠模型的稳态可塑性
  • 批准号:
    10292029
  • 财政年份:
    2021
  • 资助金额:
    $ 101万
  • 项目类别:
Neuroprotection within the aging mammalian neuromuscular system
衰老哺乳动物神经肌肉系统内的神经保护
  • 批准号:
    10190392
  • 财政年份:
    2021
  • 资助金额:
    $ 101万
  • 项目类别:
Homeostatic Plasticity in Mouse Model of Jordan's Syndrome
乔丹氏综合症小鼠模型的稳态可塑性
  • 批准号:
    10451713
  • 财政年份:
    2021
  • 资助金额:
    $ 101万
  • 项目类别:
Neuroprotection within the aging mammalian neuromuscular system
衰老哺乳动物神经肌肉系统内的神经保护
  • 批准号:
    10404112
  • 财政年份:
    2021
  • 资助金额:
    $ 101万
  • 项目类别:
Non-Neuronal Sleep/Wake Control in Cortex
皮层的非神经元睡眠/唤醒控制
  • 批准号:
    10591515
  • 财政年份:
    2020
  • 资助金额:
    $ 101万
  • 项目类别:
Non-Neuronal Sleep/Wake Control in Cortex
皮层的非神经元睡眠/唤醒控制
  • 批准号:
    10356161
  • 财政年份:
    2020
  • 资助金额:
    $ 101万
  • 项目类别:
Homeostatic Stabilization of Neural Function in Health and Disease
健康和疾病中神经功能的稳态稳定
  • 批准号:
    10530627
  • 财政年份:
    2016
  • 资助金额:
    $ 101万
  • 项目类别:
Homeostatic Stabilization of Neural Function in Health and Disease
健康和疾病中神经功能的稳态稳定
  • 批准号:
    10312780
  • 财政年份:
    2016
  • 资助金额:
    $ 101万
  • 项目类别:
Homeostatic Stabilization of Neural Function in Health and Disease
健康和疾病中神经功能的稳态稳定
  • 批准号:
    10059273
  • 财政年份:
    2016
  • 资助金额:
    $ 101万
  • 项目类别:

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