Training in Reproductive Sciences

生殖科学培训

• 批准号: 9385648
• 负责人: PAMELA L MELLON
• 金额: $ 0.68万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-12-01 至 2017-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9385648
• 关键词: Science; Training; reproductive

DESCRIPTION (provided by applicant): The urgency and importance of producing critically needed basic, translational, and clinical scientists in the area of women's health and reproduction is well recognized by the leadership of NIH, the scientific community, the national government, and the society as a whole. The UCSD T32 Training Program in Reproductive Sciences takes a unique multidisciplinary approach to the training of postdoctoral scholars as physician- scientists and reproductive biologists in the field of neuroendocrine and endocrine control of reproductive processes. The combination of clinical, physiological, and molecular approaches to reproductive biology and medicine creates an exceptional opportunity for the training of physician-scientists and basic scientists, as well- rounded reproductive endocrinologists who become extraordinarily qualified for academic careers. The program supports both fellows seeking advanced basic/translational research experience after the Ph.D. and/or M.D. degree, and those seeking clinical and research training with the aim of becoming board-certified in Reproductive Endocrinology and Infertility and continuing in academic clinical research. We have an outstanding 30-year track record as recognized by an NIH MENTOR AWARD that extended the program for 10 years from 2003-2012. A cohesive group of NIH-funded faculty from the Division of Reproductive Endocrinology in the Department of Reproductive Medicine and the Division of Endocrinology in the Department of Medicine at UCSD with common interests, shared grants, joint publications, and complimentary backgrounds, provides basic, translational, and clinical training and fosters the success and careers of the trainees. All faculty are members of the UCSD NICHD U54 Specialized Cooperative Centers Program in Reproductive and Infertility Research and all of the senior faculty members are mentors in the UCSD NICHD K12 Women's Reproductive Health Research Program for the training of OB/GYN junior faculty in research careers. Thus, this training program is integrated with both NICHD Centers, allowing the faculty and fellows to interact at many levels, creating an atmosphere of cooperation, collaboration, mentoring, and career support. Our research activities range from molecular to patient-oriented research utilizing models from in vitro analysis and cell culture, to whole animal and clinical research. Major foci of investigation include: gonadal, pituitary and hypothalamic development, ovarian physiology, polycystic ovary disease, signal transduction, Kisspeptin, NeurokininB, GnRH, and gonadotropin gene expression and secretion, metabolic impact on reproductive function, and activin and growth factors in reproduction. The program of training for the fellows includes group meetings and presentations, journal clubs, seminars, national meetings, clinical activity and training, laboratory training, independent research, grantsmanship training, and coursework in molecular biology, neuroendocrinology, bio- statistics, and ethics, and an innovative "Thesis Committee" mentoring structure. Our aim is to prepare outstanding physician-scientists and basic scientists to become the future leaders in academic reproductive research.

描述(由申请人提供)：NIH领导层、科学界、国家政府和整个社会都很好地认识到在妇女健康和生殖领域培养急需的基础、翻译和临床科学家的紧迫性和重要性。UCSD T32生殖科学培训项目采用了一种独特的多学科方法，将博士后学者培养为神经内分泌和生殖过程内分泌控制领域的内科科学家和生殖生物学家。生殖生物学和医学的临床、生理和分子方法的结合为培养内科科学家和基础科学家以及全面发展的生殖内分泌学家创造了一个特殊的机会，他们变得非常有资格从事学术事业。该计划既支持那些在博士和/或医学学位后寻求高级基础/翻译研究经验的研究员，也支持那些寻求临床和研究培训以获得生殖内分泌学和不孕症委员会认证并继续进行学术临床研究的人。我们拥有出色的30年跟踪记录，这一点得到了NIH导师奖的认可，该奖项将该计划从2003年延长至2012年10年。由美国国立卫生研究院资助的来自加州大学生殖医学系生殖内分泌学部和加州大学圣迭戈分校医学系内分泌学部的教师组成了一个有凝聚力的小组，他们有共同的兴趣、共享的赠款、联合出版物和互补的背景，提供基本的、翻译的和临床培训，并促进学员的成功和职业生涯。所有教员都是UCSD NICHD U54生殖与不孕研究专业合作中心计划的成员，所有资深教员都是UCSD NICHD K12妇女生殖健康研究计划的导师，以培训OB/GYN初级教员的研究生涯。因此，该培训计划与两个NICHD中心整合在一起，允许教职员工和研究员在多个层面上进行互动，创造了合作、协作、指导和职业支持的氛围。我们的研究活动范围从分子到以患者为中心的研究，利用从体外分析和细胞培养的模型，到整个动物和临床研究。主要研究内容包括：性腺、垂体和下丘脑发育，卵巢生理，多囊卵巢疾病，信号转导，Kispeptin，NeurokininB，GnRH，GnRH和GnRH基因的表达和分泌，代谢对生殖功能的影响，以及生殖中的激活素和生长因子。对研究员的培训计划包括小组会议和演讲、期刊俱乐部、研讨会、国家会议、临床活动和培训、实验室培训、独立研究、赠款培训、分子生物学、神经内分泌学、生物统计学和伦理学的课程工作，以及创新的“论文委员会”指导结构。我们的目标是培养优秀的内科科学家和基础科学家，使他们成为未来学术生殖研究的领导者。