Development of Dual-Polarity GRAPPA for Echo Planar Imaging Methods

用于平面回波成像方法的双极性 GRAPPA 的开发

• 批准号: 9388171
• 负责人: William Scott Hoge
• 金额: $ 8.88万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-01 至 2019-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9388171
• 关键词: Affective; Air; Blood; Brain; Brain imaging; Calibration; Clinical; Clinical Protocols; Clinical Research; Data; Development; Diagnosis; Diffusion; Diffusion Magnetic Resonance Imaging; Disease; Echo-Planar Imaging; Excision; Freezing; Functional Imaging; Functional Magnetic Resonance Imaging; Image; Imaging Techniques; Imaging technology; Individual; Inferior; Location; Magnetic Resonance Imaging; Magnetism; Maps; Measures; Mental disorders; Methods; Modeling; Monitor; Morphologic artifacts; Motion; Nervous System Physiology; Neurons; Outcomes Research; Patients; Pattern; Performance; Perfusion; Physiologic pulse; Predisposition; Preparation; Process; Protocols documentation; Psychiatric Diagnosis; RF coil; Research; Resolution; Sampling; Signal Transduction; Slice; Source; Speed; Structure; Techniques; Temporal Lobe; Testing; Time; Tissues; clinical application; data acquisition; detector; frontal lobe; image reconstruction; imaging modality; imaging study; improved; individualized medicine; innovation; motion sensitivity; neuroimaging; neuropsychiatric disorder; new technology; next generation; perfusion imaging; reconstruction; routine imaging; success

The diagnosis and treatment of neuropsychiatric disorders critically depends on characterizing neurological function and the ow of blood in the brain. Functional MRI using the EPI sequence is the current imaging standard for investigating brain function. At ultrahigh eld strength, 7 Tesla, the study of brain function and perfusion is limited by imaging artifacts that are inherent in the EPI data acquisition process. One dominant artifact is EPI ghosting which manifests as copies of the measured signal displaced from the original source location. In certain cases, these displaced copies can appear as ripple artifacts that may change over course of an imaging session, introducing temporal instability into the data. These artifacts appear more prominently at higher magnetic eld strength, particularly when imaging structures deep within the brain. We recently presented a new method, Dual-Polarity GRAPPA (DPG), that ef ciently models and corrects the data sampling inconsistencies that cause ghost and ripple artifacts. This proposal seeks to apply this new method to clinical applications where these artifacts appear, including functional, perfusion, and diffusion studies. In Aim 1, we will apply the new DPG method to clinical protocols for functional, perfusion, and diffusion studies on 3 Tesla scanners, and characterize the signal loss, temporal stability, motion sensitivity, and artifact levels compared to conventional methods. In addition, we will incorporate the DPG method into a new EPI acquisition mechanism that acquires multiple image slices simultaneously. In Aim 2, we well apply these techniques to advanced research diffusion and functional protocols for 7 Tesla scanners, and test the methods' ability to restore signal data that is lost using current image acquisition methods. The success of our proposal will be identi ed by the ability to characterize an improvement in temporal stability in functional, diffusion, and perfusion imaging applications. The successful completion of this project will directly improve imaging studies at both 3T and 7T eld strength, by improving sensitivity in methods that image the inferior frontal cortex and temporal lobes.

神经精神障碍的诊断和治疗关键取决于表征 神经功能和大脑中的血液流动。使用EPI序列的功能性MRI是 目前研究大脑功能的成像标准。 在7特斯拉的磁场强度下，大脑功能和灌注的研究受到限制， EPI数据采集过程中固有的成像伪影。一个主要的人工制品是 EPI重影，表现为从原始源位移的测量信号的副本 位置.在某些情况下，这些移位的副本可以显示为可能改变的涟漪伪影 在成像会话过程中，将时间不稳定性引入数据。这些文物 在磁场强度较高时，尤其是在成像结构时， 在大脑深处 我们最近提出了一种新的方法，双极性GRAPPA（DPG）， 并校正引起重影和涟漪伪像的数据采样不一致性。这项建议 试图将这种新方法应用于出现这些伪影的临床应用，包括 功能、灌注和扩散研究。 在目标1中，我们将新的DPG方法应用于功能，灌注， 和扩散研究，并表征信号损失，时间稳定性， 运动灵敏度和伪影水平。此外，我们将 将DPG方法合并到采集多个图像新EPI采集机制中 切片同时在目标2中，我们很好地将这些技术应用于高级研究扩散 和7特斯拉扫描仪的功能协议，并测试该方法恢复信号数据的能力 使用当前的图像获取方法会丢失这些信息。 我们的提案是否成功，将通过描述改进的能力来确定艾德 在功能、扩散和灌注成像应用中的时间稳定性。成功 该项目的完成将直接改善3T和7T场强下的成像研究， 提高了对下额叶皮层和颞叶进行成像的方法的灵敏度。