Defining Pathways in COPD Patient Oriented Research

定义以 COPD 患者为导向的研究途径

• 批准号: 9369171
• 负责人: MeiLan K Han
• 金额: $ 11.9万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-01 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9369171
• 关键词: Area; Award; Bronchodilator Agents; Caliber; Characteristics; Chest; Chronic Obstructive Airway Disease; Clinical; Clinical Sciences; Clinical Trials; Collaborations; Data; Development; Diagnostic radiologic examination; Disease; Disease Outcome; Disease Progression; Event; Evolution; Frequencies; Funding; Future; Gases; Gender; Goals; Grant; Health; Heterogeneity; Histologic; Image; Impairment; Individual; Institutes; Intervention; Lead; Lesion; Lung; Lung diseases; Mediating; Mentors; Methodology; Michigan; Mid-Career Clinical Scientist Award (K24); Minority; Mission; National Heart, Lung, and Blood Institute; Obstruction; Outcome; Pathologic; Pathway interactions; Patients; Physicians; Prevention education; Public Health Schools; Publications; Pulmonary Emphysema; Recruitment Activity; Research; Research Infrastructure; Research Personnel; Research Support; Research Training; Resources; Respiratory Signs and Symptoms; Respiratory physiology; Risk; Scientist; Smoker; Symptoms; Techniques; Terminal Bronchiole; Therapeutic Trials; Time; TimeLine; Training; Training Programs; Translational Research; Universities; Variant; Woman; Work; X-Ray Computed Tomography; analytical method; career; clinically relevant; clinically significant; cohort; disease heterogeneity; ethnic minority population; exercise capacity; experience; follow-up; gender difference; image registration; imaging biomarker; individual patient; interest; men; multidisciplinary; patient oriented research; personalized medicine; predictive of treatment response; programs; pulmonary function; racial minority; response; responsible research conduct; skills; small airways disease; symptomatic improvement; targeted treatment; therapy development; training opportunity; treatment response

ABSTRACT Dr. Han is a physician scientist with a focus in chronic obstructive pulmonary disease (COPD) patient-oriented research (POR). Her mentoring objectives under this award will be able to take on new mentees and further develop her own skills as a mentor in COPD POR. Dr. Han proposes to focus in particular on training individuals from groups who are who are currently underrepresented in COPD POR including women and racial and ethnic minorities. Protected time from this award would allow her to take coursework to acquire new analytic and mentoring skills. Additionally, this award would provide her with protected time to expand the number of mentees she can oversee as well as the resources she can provide for them. As part of her program, Dr. Han will tailor a mentoring plan to each trainee consisting of one-on-one mentoring sessions, collaboration with statisticians and formal educational opportunities in analytic methods and the responsible conduct of research. Each candidate will create a publication, presentation and funding timeline. The resources available at the University of Michigan (UM) including the UM Pulmonary Division Multidisciplinary Training Grant (T32 HL07749-24), the Michigan Institute for Clinical & Health Research/Clinical & Translational Science Award (MICHR/CTSA, UL1TR000433) and close collaboration with the UM School of Public Health provide an ideal infrastructure for POR training. Dr. Han's scientific aims for this proposal will extend her existing research into two new areas. The first aim will be to use CT imaging analytic techniques developed at UM to understand variation in COPD clinical outcomes and disease progression with a particular focus on the influence of gender. The second research aim will be to (a) understand the long-term clinical significance of smokers with symptoms but preserved pulmonary function; and (b) determine whether in this same group of individuals the presence of CT defined small airway abnormality at baseline helps to predict treatment response to a long-acting bronchodilator. Dr. Han will be able to leverage her broad COPD POR portfolio for these analyses. This portfolio includes two R01's to investigate imaging biomarkers in the COPDGene and SPIROMICS cohorts. Dr. Han is also Co-PI of an NHLBI funded therapeutic trial of a bronchodilator in current and former smokers with respiratory symptoms but preserved pulmonary function (Redefining THerapy IN COPD, RETHINC). These studies will also provide significant networking opportunities for trainees. Dr. Han is at an ideal stage of her career to take advantage of a K24 award. She is deeply committed to an investigative career in COPD POR as well as enriching the diversity of future COPD POR investigators which aligns with two of the NHLBI's missions: (1) to promote research, training, and education for the prevention and treatment of lung disease; and (2) increasing the diversity of our national research workforce.

摘要 博士Han是一名医生科学家，专注于慢性阻塞性肺疾病（COPD）患者导向 研究（POR）。她在该奖项下的指导目标将能够接受新的学员，并进一步 发展自己作为COPD POR导师的技能。韩博士建议特别注重培训 目前COPD POR中代表性不足的群体中的个体，包括女性， 种族和少数民族。从这个奖项的保护时间将允许她参加课程，以获得新的 分析和指导技能。此外，该奖项将为她提供受保护的时间来扩大 她可以监督的学员人数以及她可以为他们提供的资源。公主随 韩博士将为每位学员量身定制一个指导计划，包括一对一的指导课程， 与统计人员合作，提供分析方法方面的正规教育机会， 进行研究。每个候选人将创建一个出版物，演示和资金时间轴。的 密歇根大学（UM）提供的资源，包括UM肺科多学科 培训补助金（T32 HL 07749 -24），密歇根临床与健康研究所/临床与转化 科学奖（MICHR/CTSA，UL 1 TR 000433），并与公共卫生的UM学校密切合作 为POR培训提供理想的基础设施。韩博士提出这项建议的科学目的将使她 现有研究分为两个新领域。第一个目标将是使用CT成像分析技术， UM了解COPD临床结局和疾病进展的变化，特别关注 性别的影响。第二个研究目标是（a）了解 具有症状但保留肺功能的吸烟者;和（B）确定在这同一组吸烟者中， 个体在基线时存在CT定义的小气道异常有助于预测治疗 对长效支气管扩张剂的反应韩博士将能够利用她广泛的COPD POR产品组合， 这些分析。该产品组合包括两个R 01，用于研究COPD基因中的成像生物标志物， SPIROMICS队列。Han博士也是目前NHLBI资助的支气管扩张剂治疗试验的共同PI。 和有呼吸道症状但保留肺功能的前吸烟者（重新定义凝血酶） 慢性阻塞性肺病，RETHINC）。这些研究还将为受训人员提供重要的联网机会。韩医生是 在她职业生涯的理想阶段，利用K24奖。她致力于调查 COPD POR的职业生涯以及丰富未来COPD POR研究人员的多样性，这与 NHLBI的两个任务：（1）促进预防和治疗的研究，培训和教育 肺疾病;（2）增加我们国家研究人员的多样性。