Defining Pathways in COPD Patient Oriented Research

摘要 韩博士是一位内科科学家，专注于慢性阻塞性肺疾病(COPD)患者导向的研究 研究(POR)。根据这一奖项，她的指导目标将能够接受新的指导对象，并进一步 在COPD POR中发展自己作为导师的技能。韩博士建议将重点放在培训上 来自目前在COPD POR中任职人数不足的群体的个人，包括妇女和 少数族裔和少数民族。不受该奖项保护的时间将允许她参加课程作业以获得新的 分析和指导技能。此外，这项奖励将为她提供受保护的时间来扩大 她可以监督的学员数量以及她可以为他们提供的资源。作为她的一部分 计划中，韩博士将为每个学员量身定做一份由一对一辅导课程组成的辅导计划， 与统计学家的合作以及在分析方法和责任人方面的正规教育机会 进行研究。每位候选人将创建一份出版物、演示文稿和资金时间表。这个 密歇根大学(UM)可用的资源，包括密歇根大学肺科多学科 培训补助金(T32 HL07749-24)，密歇根临床与健康研究所/临床与翻译研究所 科学奖(MICHR/CTSA，UL1TR000433)，并与密歇根大学公共卫生学院密切合作 为POR培训提供理想的基础设施。韩博士对这项提议的科学目标将使她 现有的研究涉及两个新领域。第一个目标是使用CT成像分析技术 UM了解COPD临床结果和疾病进展的差异，特别关注 性别的影响。第二项研究的目的将是(A)了解心力衰竭的长期临床意义。 有症状但肺功能保留的吸烟者；以及(B)确定在这同一组人中 基线时CT定义的小气道异常有助于预测治疗 对长效支气管扩张剂的反应。韩博士将能够利用她广泛的COPD POR组合 这些分析。该组合包括两个R01‘S，研究COPD基因和COPD基因中的成像生物标记物 SPIROMICS队列。韩博士也是NHLBI资助的一项目前正在进行的支气管扩张剂治疗试验的联合PI 和有呼吸道症状但肺功能保留的前吸烟者(重新定义治疗 COPD，RETHINC)。这些研究还将为受训人员提供重要的网络机会。韩博士是 在她职业生涯的理想阶段，利用K24奖项。她坚定地致力于调查 在COPD POR方面的职业生涯，以及丰富未来COPD POR调查人员的多样性 NHLBI的两项任务：(1)促进预防和治疗方面的研究、培训和教育 (2)增加我们国家研究人员的多样性。

ABSTRACT Dr. Han is a physician scientist with a focus in chronic obstructive pulmonary disease (COPD) patient-oriented research (POR). Her mentoring objectives under this award will be able to take on new mentees and further develop her own skills as a mentor in COPD POR. Dr. Han proposes to focus in particular on training individuals from groups who are who are currently underrepresented in COPD POR including women and racial and ethnic minorities. Protected time from this award would allow her to take coursework to acquire new analytic and mentoring skills. Additionally, this award would provide her with protected time to expand the number of mentees she can oversee as well as the resources she can provide for them. As part of her program, Dr. Han will tailor a mentoring plan to each trainee consisting of one-on-one mentoring sessions, collaboration with statisticians and formal educational opportunities in analytic methods and the responsible conduct of research. Each candidate will create a publication, presentation and funding timeline. The resources available at the University of Michigan (UM) including the UM Pulmonary Division Multidisciplinary Training Grant (T32 HL07749-24), the Michigan Institute for Clinical & Health Research/Clinical & Translational Science Award (MICHR/CTSA, UL1TR000433) and close collaboration with the UM School of Public Health provide an ideal infrastructure for POR training. Dr. Han's scientific aims for this proposal will extend her existing research into two new areas. The first aim will be to use CT imaging analytic techniques developed at UM to understand variation in COPD clinical outcomes and disease progression with a particular focus on the influence of gender. The second research aim will be to (a) understand the long-term clinical significance of smokers with symptoms but preserved pulmonary function; and (b) determine whether in this same group of individuals the presence of CT defined small airway abnormality at baseline helps to predict treatment response to a long-acting bronchodilator. Dr. Han will be able to leverage her broad COPD POR portfolio for these analyses. This portfolio includes two R01's to investigate imaging biomarkers in the COPDGene and SPIROMICS cohorts. Dr. Han is also Co-PI of an NHLBI funded therapeutic trial of a bronchodilator in current and former smokers with respiratory symptoms but preserved pulmonary function (Redefining THerapy IN COPD, RETHINC). These studies will also provide significant networking opportunities for trainees. Dr. Han is at an ideal stage of her career to take advantage of a K24 award. She is deeply committed to an investigative career in COPD POR as well as enriching the diversity of future COPD POR investigators which aligns with two of the NHLBI's missions: (1) to promote research, training, and education for the prevention and treatment of lung disease; and (2) increasing the diversity of our national research workforce.