Predicting Voice Quality in ASD from Early Markers of Vocal Development

从发声发展的早期标志预测自闭症谱系障碍 (ASD) 的语音质量

• 批准号: 9316586
• 负责人: Shweta Ghai
• 金额: $ 6.41万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-01 至 2018-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9316586
• 关键词: Acoustics; Address; Affect; Age; Area; Autistic Disorder; Behavior; Caregivers; Characteristics; Child; Child Language; Clinic; Clinical; Clinical assessments; Comorbidity; Competence; Development; Developmental Delay Disorders; Diagnosis; Dimensions; Disease; Early Diagnosis; Early treatment; Employment; Environment; Etiology; Exhibits; Frequencies; Functional disorder; Goals; Heterogeneity; Home environment; Impairment; Individual; Infant; Intervention; Investigation; Laboratories; Language; Larynx; Lead; Left; Life; Light; Measurable; Measurement; Measures; Mediating; Methods; Motor; Outcome; Outcome Measure; Physiological; Process; Production; Public Health; Recruitment Activity; Research; Risk; Role; Siblings; Social Interaction; Source; Speech; Speech Development; Strategic Planning; Syndrome; TNFRSF5 gene; Testing; Time; United States National Institutes of Health; Voice; Voice Quality; autism spectrum disorder; base; cohort; design; high risk; high risk infant; improved; insight; motor control; motor deficit; novel; phonology; public health relevance; social; social communication; social integration; syntax; vocalization

 DESCRIPTION (provided by applicant): The goal of this project is to test the hypothesis that the emergence of atypical voice quality in children with autism is an attribute of core impairments in social interaction against the hypothesis that voice quality disorders are an early outcome of comorbid motor deficits in vocal production in autism spectrum disorders (ASD). By cross-analyzing electroglottographic (EGG) recordings and longitudinal audio recordings of the home language environment for 80 children with and without ASD, we will be able to determine if acoustic measures of early vocal development can predict atypical voice quality outcome assessed with electroglottography. This will aid the development of efficient methods for early detection and treatment of voice quality disorders in ASD. The first specific aim is to characterize voice quality development in children with ASD, non-autistic developmental delays and typical development, using glottal source parameters estimated from EGG recordings at the age of 24 months. A novel video-based clinical assessment paradigm that we have specially designed to elicit vocalizations from children with autism will be used to collect EGG recordings from children. The second specific aim is to determine the relation between vocal development in the first two years of life and voice quality outcome at the end of the second year of life, by comparing developmental trajectories for acoustic measures of vocal production derived from home audio recordings to voice quality measures determined from EGG recordings. The third specific aim is to determine the correlation between voice quality measures, acoustic measures of vocal production and clinical assessment measures for deficits in speech motor control and social interaction in children with ASD. Accomplishing these three aims will reveal how voice quality disorders are associated with comorbid speech motor deficits and core impairments in social interaction in autism. This research addresses two themes in the IACC Strategic Plan: `Novel Research Strategies', and `Heterogeneity'.

 描述(由申请者提供)：本项目的目标是测试以下假设，即自闭症儿童中非典型嗓音质量的出现是社交中核心障碍的一个属性，而不是语音质量障碍是自闭症谱系障碍(ASD)患者发声运动障碍的早期结果。通过交叉分析80名患有和不患有ASD的儿童的电声门图(EGG)记录和家庭语言环境的纵向音频记录，我们将能够确定早期声音发育的声学测量是否可以预测电声门图评估的非典型嗓音质量结果。这将有助于开发有效的方法来早期发现和治疗ASD的语音质量障碍。第一个具体目标是利用24个月大的鸡蛋录音估计的声门源参数，表征患有自闭症、非自闭症发育迟缓和典型发育的儿童的嗓音质量发展。我们专门设计了一种新的基于视频的临床评估范式，以诱导自闭症儿童发声，该范式将被用于收集儿童的鸡蛋录音。第二个具体目标是通过比较来自家庭录音的发声声学测量的发展轨迹和从鸡蛋录音确定的发声质量测量来确定生命头两年的嗓音发育与第二年结束时的嗓音质量结果之间的关系。第三个具体目标是确定自闭症儿童发声质量指标、发声发声声学指标和言语运动控制和社会互动缺陷的临床评估指标之间的相关性。实现这三个目标将揭示语音质量障碍如何与自闭症患者的言语、运动障碍和社交中的核心障碍相关联。这项研究涉及IACC战略计划中的两个主题：“新研究战略”和“异质性”。