课题基金 / 基金详情

Model of mitochondrial function

Model of mitochondrial function
线粒体功能模型
批准号：
9553214
负责人：
Vipul Periwal
金额：
$13.35万
依托单位：
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/9553214
关键词：
AdenosineAffectAgonistAlzheimer&aposs DiseaseAreaAtherosclerosisBiogenesisCalciumCalcium ChannelCalcium OscillationsCellsCharacteristicsClinical ResearchCytosolDiabetes MellitusDietDiseaseEnvironmental Risk FactorEnzyme ActivationEventEvolutionFunctional disorderGenerationsGlucoseGlucose Plasma ConcentrationHigh Fat DietHomeostasisHydrogen PeroxideHydroxyl RadicalInner mitochondrial membraneInsulinInsulin ResistanceLipidsLongevityMembraneMembrane PotentialsMitochondriaModelingMyopathyObesityOrganellesParkinson DiseasePathway interactionsPhysical activityPlasmaPlayPositioning AttributePotassium ChannelProductionProteinsProton-Motive ForceReactive Oxygen SpeciesRegulationRoleSarcoplasmic ReticulumSeriesSignal TransductionSignaling ProteinSiteSourceStressStructure of beta Cell of isletSuperoxidesTherapeuticTissuesclinically relevantinsightinsulin secretionmathematical modelmitochondrial dysfunctionmitochondrial membranemitochondrial metabolismpredictive modelingvoltage

项目摘要

项目成果

Vipul Periwal的其他基金

相似基金

相关文献

中文摘要
翻译
点击翻译按钮获取中文摘要
英文摘要
We find that, for a range of agonist concentration, Ca2+ dynamics in ER-mitochondria nanodomains is essential for maintaining intracellular calcium oscillations. The model predicts faster Ca2+ oscillations when there is an increase in the volume ratio between ER-mitochondrial nanodomains and the cytosol. Moreover, given that the production of adenosine trisphosphate (ATP) and the generation of reactive oxygen species (ROS) are closely associated with mitochondrial Ca2+, the model also provides some insights into the relationship between ER-mitochondria nanodomains Ca2+ dynamics and mitochondrial function. We investigate, computationally, strategies for alleviating the progress of dysfunction associated with aberrant Ca2+ dynamics.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Single Cell Data Analysis Algorithms
Single Cell Data Analysis Algorithms
Inferring epidemic characteristics with networks
Model of mitochondrial function
海外基金