Program 3: Cancer BiologyProgram (CBP)

计划 3：癌症生物学计划 (CBP)

• 批准号: 9315740
• 负责人: Nathan A. Ellis
• 金额: $ 0.63万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-01 至 2021-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9315740
• 关键词: Address; Advanced Development; Area; Arizona; Arsenicals; Automobile Driving; Basic Science; Bioinformatics; Biological; Biological Models; Cancer Biology; Cancer Center; Cancer Center Support Grant; Cancer Control; Cancer Science; Cancer cell line; Catchment Area; Clinical Research; Clinical Trials; Collaborations; Complex; DNA Sequence Alteration; Development; Dictyostelium discoideum; Drosophila melanogaster; Environment; Environmental Carcinogens; Environmental Risk Factor; Epigenetic Process; Etiology; Event; Faculty Recruitment; Fostering; Foundations; Funding; Future; Gene Expression; Genetic Models; Genomic Instability; Genomics; Goals; Grant; Heterogeneity; Hispanic Americans; House mice; Individual; Intervention; Knowledge; Malignant Neoplasms; Manuscripts; Mediating; Mentors; Modernization; Mutation; Nature; Neoplasm Metastasis; Organ; Outcome; Patients; Peer Review; Phenotype; Population; Precision Medicine Initiative; Prevention; Publishing; Recruitment Activity; Regulatory Pathway; Research; Research Personnel; Resource Sharing; Saccharomyces cerevisiae; Secure; Signal Pathway; Signal Transduction; Targeted Research; Training Programs; Translational Research; Translations; Universities; Xenograft procedure; cancer cell; cancer health disparity; cancer initiation; cancer prevention; cancer therapy; carcinogenesis; carcinogenicity; cell type; genomic platform; human tissue; improved; member; mouse model; novel; novel strategies; patient population; pre-clinical; precision medicine; preclinical study; programs; success; symposium; tumor progression; working group

Project Summary / Abstract: Cancer Biology Program (CBP) The goal of the Cancer Biology Program (CBP) is to identify etiologic mechanisms underlying cancer development and progression. As the main basic science of cancer platform for the University of Arizona Cancer Center, the Cancer Biology Program seeks to advance fundamental knowledge of the complex biological networks that are deranged in cancer and to characterize interactions between these complex biological networks and the environment that promote carcinogenesis and tumor progression. Translation of current findings and development of novel approaches to cancer prevention and treatment is facilitated through inter-programmatic collaborations and Cancer Center support. The program is organized into three major themes, including Genomic Instability and Epigenetic Control of Gene Expression, Signaling Networks in Carcinogenesis and Tumor Progression, and Invasion and Metastasis, with four aims: (i) to investigate mechanisms of cancer initiation and progression and to characterize cellular mechanisms that control cancer metastasis, (ii) to identify networks and regulatory pathways as potential markers or targets in prevention and treatment, (iii) to promote intra- and inter-programmatic collaborations to enhance translational research along the continuum from pre-clinical mouse models and human tissue correlates to clinical trials, and (iv) to foster research directions of particular relevance to individuals in Arizona and the Southwest. The Cancer Biology Program achieves these aims through establishment of working groups, conferences and seminars, and development of inter-disciplinary scientific teams; faculty recruitment, membership development and mentoring, and the use of developmental funds to spur targeted research; and, guidance and support of the shared resources. The CBP has 49 Members representing 21 different departments at the University of Arizona. CBP Members have published 390 cancer-relevant manuscripts, of which 30% were intra- programmatic and 36% were inter-programmatic. As of September 1, 2015, the CBP Program secured $11.8M total annual grant dollars with $2.5M from the NCI and $8.3M in other peer-reviewed funding. The CBP has regional impact through its members' basic research into the carcinogenic mechanisms of arsenicals that are pervasive environmental carcinogens in the Southwest. Finally, the Program is invested in using modern, high throughput genomic platforms to develop, enhance, and implement precision medicine. The expanding representation of Hispanic Americans in the State's population impels increased research into cancer health disparities in this population.

项目概述/摘要：癌症生物学项目（CBP）