Program 3: Cancer BiologyProgram (CBP)

计划 3：癌症生物学计划 (CBP)

• 批准号: 9315740
• 负责人: Nathan A. Ellis
• 金额: $ 0.63万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-01 至 2021-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9315740
• 关键词: Address; Advanced Development; Area; Arizona; Arsenicals; Automobile Driving; Basic Science; Bioinformatics; Biological; Biological Models; Cancer Biology; Cancer Center; Cancer Center Support Grant; Cancer Control; Cancer Science; Cancer cell line; Catchment Area; Clinical Research; Clinical Trials; Collaborations; Complex; DNA Sequence Alteration; Development; Dictyostelium discoideum; Drosophila melanogaster; Environment; Environmental Carcinogens; Environmental Risk Factor; Epigenetic Process; Etiology; Event; Faculty Recruitment; Fostering; Foundations; Funding; Future; Gene Expression; Genetic Models; Genomic Instability; Genomics; Goals; Grant; Heterogeneity; Hispanic Americans; House mice; Individual; Intervention; Knowledge; Malignant Neoplasms; Manuscripts; Mediating; Mentors; Modernization; Mutation; Nature; Neoplasm Metastasis; Organ; Outcome; Patients; Peer Review; Phenotype; Population; Precision Medicine Initiative; Prevention; Publishing; Recruitment Activity; Regulatory Pathway; Research; Research Personnel; Resource Sharing; Saccharomyces cerevisiae; Secure; Signal Pathway; Signal Transduction; Targeted Research; Training Programs; Translational Research; Translations; Universities; Xenograft procedure; cancer cell; cancer health disparity; cancer initiation; cancer prevention; cancer therapy; carcinogenesis; carcinogenicity; cell type; genomic platform; human tissue; improved; member; mouse model; novel; novel strategies; patient population; pre-clinical; precision medicine; preclinical study; programs; success; symposium; tumor progression; working group

Project Summary / Abstract: Cancer Biology Program (CBP) The goal of the Cancer Biology Program (CBP) is to identify etiologic mechanisms underlying cancer development and progression. As the main basic science of cancer platform for the University of Arizona Cancer Center, the Cancer Biology Program seeks to advance fundamental knowledge of the complex biological networks that are deranged in cancer and to characterize interactions between these complex biological networks and the environment that promote carcinogenesis and tumor progression. Translation of current findings and development of novel approaches to cancer prevention and treatment is facilitated through inter-programmatic collaborations and Cancer Center support. The program is organized into three major themes, including Genomic Instability and Epigenetic Control of Gene Expression, Signaling Networks in Carcinogenesis and Tumor Progression, and Invasion and Metastasis, with four aims: (i) to investigate mechanisms of cancer initiation and progression and to characterize cellular mechanisms that control cancer metastasis, (ii) to identify networks and regulatory pathways as potential markers or targets in prevention and treatment, (iii) to promote intra- and inter-programmatic collaborations to enhance translational research along the continuum from pre-clinical mouse models and human tissue correlates to clinical trials, and (iv) to foster research directions of particular relevance to individuals in Arizona and the Southwest. The Cancer Biology Program achieves these aims through establishment of working groups, conferences and seminars, and development of inter-disciplinary scientific teams; faculty recruitment, membership development and mentoring, and the use of developmental funds to spur targeted research; and, guidance and support of the shared resources. The CBP has 49 Members representing 21 different departments at the University of Arizona. CBP Members have published 390 cancer-relevant manuscripts, of which 30% were intra- programmatic and 36% were inter-programmatic. As of September 1, 2015, the CBP Program secured $11.8M total annual grant dollars with $2.5M from the NCI and $8.3M in other peer-reviewed funding. The CBP has regional impact through its members' basic research into the carcinogenic mechanisms of arsenicals that are pervasive environmental carcinogens in the Southwest. Finally, the Program is invested in using modern, high throughput genomic platforms to develop, enhance, and implement precision medicine. The expanding representation of Hispanic Americans in the State's population impels increased research into cancer health disparities in this population.

项目摘要/摘要：癌症生物学计划（CBP） 癌症生物学计划（CBP）的目标是确定癌症的病因机制 发展和进步。作为亚利桑那大学的主要癌症基础科学平台 癌症中心，癌症生物学计划旨在推进复杂的基础知识 这些复杂的生物网络之间的相互作用， 生物网络和环境，促进致癌和肿瘤进展。翻译 通过以下方式促进了癌症预防和治疗的新方法的当前发现和发展： 项目间合作和癌症中心支持。该计划分为三大部分 主题，包括基因组不稳定性和基因表达的表观遗传控制， 癌症发生和肿瘤进展，以及侵袭和转移，有四个目的：（i）研究 癌症发生和发展的机制，并表征控制癌症的细胞机制 转移，（ii）识别网络和调节途径作为预防中的潜在标志物或靶标， 治疗，（iii）促进项目内和项目间的合作，以加强转化研究，沿着 从临床前小鼠模型和人体组织的连续体与临床试验相关，以及（iv）培养 与亚利桑那州和西南部的个人特别相关的研究方向。癌症生物学 方案通过建立工作组、会议和研讨会实现这些目标， 跨学科科学团队的发展;教师招聘，会员发展和 指导，以及使用发展基金来刺激有针对性的研究;以及，指导和支持 共享资源。CBP有49名成员，分别代表香港大学21个不同的系。 亚利桑那CBP成员发表了390篇与癌症相关的手稿，其中30%是内部的， 36%是方案性的，36%是方案间的。截至2015年9月1日，CBP计划获得了1180万美元 年度总赠款美元，其中250万美元来自NCI，830万美元来自其他同行评审资金。CBP已经 通过其成员对砷剂致癌机制的基础研究， 在西南部普遍存在的环境致癌物。最后，该计划投资于使用现代化的，高 通过基因组平台来开发、增强和实施精准医疗。不断扩大的 西班牙裔美国人在该州人口中的代表性推动了对癌症健康的研究 这一人群中的差异。